Details of Drug

Drug General Information (ID: D1341)
Drug Name	Probenecid
Drug Type	Small molecule
Drug Synonymous	Apurina; Bencid; Benecid; Benemid; Benemide; Benuryl; Panuric; Parabenem; Probalan; Probampacin; Probecid; Proben; Probenecida; Probenecide; Probenecidum; Probenemid; Probenicid; Probenid; Probexin; Prolongine; Robenecid; Sulprin; Tubophan; Uricosid; Urocid; Biokanol Brand of Probenecid; ICN Brand of Probenecid; IDIS Brand of Probenecid; Major Brand of Probenecid; Martec Brand of Probenecid; Merck Brand of Probenecid; Ophthalmic Brand of Probenecid; Parmed Brand of Probenecid; Probenecid Major Brand; Probenecid Martec Brand; Probenecid Parmed Brand; Probenecid Weimer; Probenecid Zenith Brand; Probenecid acid; Synergid R; Valdecasas Brand of Probenecid; Zenith Brand of Probenecid; Benemid (TN); Benuryl (TN); Col-BENEMID; ColBenemid (co mponent of); ColBenemid (component of); P-[Dipropylsulfamoyl]benzoic acid; Polycillin-BRB; Pro-Cid; Probenecida [INN-Spanish]; Probenecide [INN-French]; Probenecidum [INN-Latin]; P-(Dipropylsulfamoyl)benzoic acid; P-(Dipropylsulfamyl)benzoic acid; Polycillin-PRB (component of); Probenecid [INN:BAN:JAN]; Probenecid (JP15/USP/INN); 4-((Dipropylamino)sulfonyl)benzoic acid;4-(Di-n-propylsulfamoyl)benzoesaeure; 4-(Dipropylsulfamoyl)benzoic acid; 4-(N,N-Dipropylsulfamoyl)benzoesaeure; 4-[(dipropylamino)sulfonyl]benzoic acid Click to Show/Hide
Disease Class	5C55: Inborn purine/pyrimidine/nucleotide metabolism error; FA25: Gout
Therapeutic Class	Uricosuric Agents
Structure
Structure	3D Structure		2D Structure
Formula	C13H19NO4S
InChI	1S/C13H19NO4S/c1-3-9-14(10-4-2)19(17,18)12-7-5-11(6-8-12)13(15)16/h5-8H,3-4,9-10H2,1-2H3,(H,15,16)
InChIKey	DBABZHXKTCFAPX-UHFFFAOYSA-N
Canonical SMILES	CCCN(CCC)S(=O)(=O)C1=CC=C(C=C1)C(=O)O
External Link
	Pubchem ID	4911
	CAS Number	57-66-9
	CHEBI ID	8426
	TTD ID	D0L7FM
	INTEDE ID	DR1341
	VARIDT ID	DR00232

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM002 Affected cellular transport AM003 Affected organization distribution AM004 Affected intra/extra-hepatic metabolism AM005 Affected excretion pathways AM006 Pharmacodynamic additive effects AM007 Pharmacodynamic antagonistic effects BM010 Transporter inhibition BM012 Competitive inhibition of transporters BM013 Competitive binding of plasma proteins BM017 CYP450 enzyme inhibition BM019 UGT inhibition BM022 CYP450 enzyme induction BM025 Decreased metabolism (Unspecific) BM028 Competitive inhibition of renal tubular secretion BM031 Increased renal excretion (Unspecific) BM032 Decreased renal excretion (Unspecific) BM050 Increased risk of bleeding BM064 Increased risk of hypoglycemia BM083 Potentiated the pharmacological effects (Unspecific) BM099 Antagonize the effect of uricosuric agents BM109 Increased risk of other adverse reactions (Unspecific)
Relation Graph

Full list of drugs interacting with Probenecid
Affected cellular transport
	Transporter inhibition					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0146		Baricitinib	C16H17N7O2S	44205240	Major		Inter Info	[1], [2], [7]
	Competitive inhibition of transporters					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1898		Tazobactam	C10H12N4O5S	123630	Moderate		Inter Info	[164], [165]
Affected organization distribution
	Competitive binding of plasma proteins					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0489		Diflunisal	C13H8F2O3	3059	Minor		Inter Info	[159], [195], [115]
Affected intra/extra-hepatic metabolism
	CYP450 enzyme inhibition					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1258		Pexidartinib	C20H15ClF3N5	25151352	Major		Inter Info	[11]
	UGT inhibition					Drug Num: 3
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0433		Deferiprone	C7H9NO2	2972	Moderate		Inter Info	[160]
D0959		Lumateperone	C24H28FN3O	21302490	Moderate		Inter Info	[162]
D1457		Selexipag	C26H32N4O4S	9913767	Moderate		Inter Info	[1], [2]
	CYP450 enzyme induction					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0255		Carbamazepine	C15H12N2O	2554	Minor		Inter Info	[188]
	Decreased metabolism (Unspecific)					Drug Num: 16
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0045		Alprazolam	C17H13ClN4	2118	Minor		Inter Info	[173], [178]
D0317		Chlordiazepoxide	C16H14ClN3O	2712	Minor		Inter Info	[173], [178]
D0356		Clobazam	C16H13ClN2O2	2789	Minor		Inter Info	[173], [178]
D0365		Clorazepic acid	C16H11ClN2O3	2809	Minor		Inter Info	[173], [178], [12]
D0473		Diazepam	C16H13ClN2O	3016	Minor		Inter Info	[173], [178]
D0679		Flurazepam	C21H23ClFN3O	3393	Minor		Inter Info	[173], [178]
D0748		Halazepam	C17H12ClF3N2O	31640	Minor		Inter Info	[173], [178]
D0951		Lorazepam	C15H10Cl2N2O2	3958	Minor		Inter Info	[173], [178]
D1060		Midazolam	C18H13ClFN3	4192	Minor		Inter Info	[173], [178]
D1197		Oxazepam	C15H11ClN2O2	4616	Minor		Inter Info	[173], [178]
D0362		Clonazepam	C15H10ClN3O3	2802	Minor		Inter Info	[173], [178]
D0604		Estazolam	C16H11ClN4	3261	Minor		Inter Info	[173], [178]
D1367		Quazepam	C17H11ClF4N2S	4999	Minor		Inter Info	[173], [178]
D1391		Remimazolam	C21H19BrN4O2	9867812	Minor		Inter Info	[173], [178]
D1547		Temazepam	C16H13ClN2O2	5391	Minor		Inter Info	[173], [178]
D1632		Triazolam	C17H12Cl2N4	5556	Minor		Inter Info	[173], [178]
Affected excretion pathways
	Competitive inhibition of renal tubular secretion					Drug Num: 87
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1025		Methotrexate	C20H22N8O5	126941	Major		Inter Info	[4], [5], [6]
D0271		Cefaclor	C15H14ClN3O4S	51039	Moderate		Inter Info	[116], [117], [118], [119], [120], [121], [122], [123], [124], [125], [126], [127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [137], [138], [139], [140], [141], [142], [143]
D0273		Cefalotin	C16H16N2O6S2	6024	Moderate		Inter Info	[123], [127], [136]
D0277		Cefdinir	C14H13N5O5S2	6915944	Moderate		Inter Info	[116], [117], [118], [119], [120], [121], [122], [123], [124], [125], [126], [127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [137], [138], [139], [140], [141], [142], [143]
D0281		Cefixime	C16H15N5O7S2	5362065	Moderate		Inter Info	[116], [117], [118], [119], [120], [121], [122], [123], [124], [125], [126], [127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [137], [138], [139], [140], [141], [142], [143]
D0282		Cefmetazole	C15H17N7O5S3	42008	Moderate		Inter Info	[116], [117], [118], [119], [120], [121], [122], [123], [124], [125], [126], [127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [137], [138], [139], [140], [141], [142], [143]
D0285		Cefotaxime	C16H17N5O7S2	5742673	Moderate		Inter Info	[116], [117], [118], [119], [120], [121], [122], [123], [124], [125], [126], [127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [137], [138], [139], [140], [141], [142], [143]
D0301		Cephalexin	C16H17N3O4S	27447	Moderate		Inter Info	[116], [117], [118], [119], [120], [121], [122], [123], [124], [125], [126], [127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [137], [138], [139], [140], [141], [142], [143]
D0419		Dapsone	C12H12N2O2S	2955	Moderate		Inter Info	[144]
D0576		Entecavir	C12H15N5O3	135398508	Moderate		Inter Info	[145]
D0710		Ganciclovir	C9H13N5O4	135398740	Moderate		Inter Info	[146], [147], [148]
D0949		Loracarbef	C16H16ClN3O4	5284585	Moderate		Inter Info	[116], [117], [118], [119], [120], [121], [122], [123], [124], [125], [126], [127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [137], [138], [139], [140], [141], [142], [143]
D1008		Meropenem	C17H25N3O5S	441130	Moderate		Inter Info	[150], [151]
D1095		Mycophenolic acid	C17H20O6	446541	Moderate		Inter Info	[152], [153]
D1102		Nalidixic acid	C12H12N2O3	4421	Moderate		Inter Info	[154], [155]
D1241		Pemetrexed	C20H21N5O6	135410875	Moderate		Inter Info	[156]
D0131		Avibactam	C7H11N3O6S	9835049	Moderate		Inter Info	[158]
D0272		Cefadroxil	C16H17N3O5S	47965	Moderate		Inter Info	[116], [117], [118], [119], [120], [121], [122], [123], [124], [125], [126], [127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [137], [138], [139], [140], [141], [142], [143]
D0274		Cefamandole	C18H18N6O5S2	456255	Moderate		Inter Info	[116], [117], [118], [119], [120], [121], [122], [123], [124], [125], [126], [127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [137], [138], [139], [140], [141], [142], [143]
D0275		Cefapirin	C17H17N3O6S2	30699	Moderate		Inter Info	[123], [127], [136]
D0276		Cefazolin	C14H14N8O4S3	33255	Moderate		Inter Info	[116], [117], [118], [119], [120], [121], [122], [123], [124], [125], [126], [127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [137], [138], [139], [140], [141], [142], [143]
D0279		Cefepime	C19H24N6O5S2	5479537	Moderate		Inter Info	[116], [117], [118], [119], [120], [121], [122], [123], [124], [125], [126], [127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [137], [138], [139], [140], [141], [142], [143]
D0283		Cefonicid	C18H18N6O8S3	43594	Moderate		Inter Info	[116], [117], [118], [119], [120], [121], [122], [123], [124], [125], [126], [127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [137], [138], [139], [140], [141], [142], [143]
D0284		Cefoperazone	C25H27N9O8S2	44187	Moderate		Inter Info	[116], [117], [118], [119], [120], [121], [122], [123], [124], [125], [126], [127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [137], [138], [139], [140], [141], [142], [143]
D0286		Cefotetan	C17H17N7O8S4	53025	Moderate		Inter Info	[116], [117], [118], [119], [120], [121], [122], [123], [124], [125], [126], [127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [137], [138], [139], [140], [141], [142], [143]
D0287		Cefoxitin	C16H17N3O7S2	441199	Moderate		Inter Info	[116], [117], [118], [119], [120], [121], [122], [123], [124], [125], [126], [127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [137], [138], [139], [140], [141], [142], [143]
D0288		Cefpodoxime	C15H17N5O6S2	6335986	Moderate		Inter Info	[116], [117], [118], [119], [120], [121], [122], [123], [124], [125], [126], [127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [137], [138], [139], [140], [141], [142], [143]
D0289		Cefprozil	C18H19N3O5S	5281006	Moderate		Inter Info	[116], [117], [118], [119], [120], [121], [122], [123], [124], [125], [126], [127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [137], [138], [139], [140], [141], [142], [143]
D0290		Cefradine	C16H19N3O4S	38103	Moderate		Inter Info	[123], [127], [136]
D0291		Ceftaroline fosamil	C22H21N8O8PS4	9852981	Moderate		Inter Info	[123], [127], [136]
D0293		Ceftibuten	C15H14N4O6S2	5282242	Moderate		Inter Info	[116], [117], [118], [119], [120], [121], [122], [123], [124], [125], [126], [127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [137], [138], [139], [140], [141], [142], [143]
D0294		Ceftizoxime	C13H13N5O5S2	6533629	Moderate		Inter Info	[116], [117], [118], [119], [120], [121], [122], [123], [124], [125], [126], [127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [137], [138], [139], [140], [141], [142], [143]
D0297		Cefuroxime	C16H16N4O8S	5479529	Moderate		Inter Info	[116], [117], [118], [119], [120], [121], [122], [123], [124], [125], [126], [127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [137], [138], [139], [140], [141], [142], [143]
D0519		Doripenem	C15H24N4O6S2	73303	Moderate		Inter Info	[161]
D1273		Phenylacetic acid	C8H8O2	999	Moderate		Inter Info	[163]
D1676		Valganciclovir	C14H22N6O5	135413535	Moderate		Inter Info	[146], [147], [148]
D1715		Zalcitabine	C9H13N3O3	24066	Moderate		Inter Info	[167], [168], [169]
D1720		Zidovudine	C10H13N5O4	35370	Moderate		Inter Info	[170], [171], [172]
D0079		Ampicillin	C16H19N3O4S	6249	Minor		Inter Info	[179], [180], [181], [182], [183], [184]
D0156		Benazepril	C24H28N2O5	5362124	Minor		Inter Info	[185], [186], [187]
D0257		Carbenicillin	C17H18N2O6S	20824	Minor		Inter Info	[179], [180], [181], [182], [183], [184]
D0340		Cinoxacin	C12H10N2O5	2762	Minor		Inter Info	[189], [190], [191]
D0341		Ciprofloxacin	C17H18FN3O3	2764	Minor		Inter Info	[189], [190], [191]
D0360		Clofibrate	C12H15ClO3	2796	Minor		Inter Info	[192]
D1768		Creatine	C4H9N3O2	586	Minor		Inter Info	[193], [12], [194]
D0480		Dicloxacillin	C19H17Cl2N3O5S	18381	Minor		Inter Info	[179], [180], [181], [182], [183], [184]
D0567		Enalapril	C20H28N2O5	5388962	Minor		Inter Info	[185], [186], [187]
D0573		Enoxacin	C15H17FN4O3	3229	Minor		Inter Info	[189], [190], [191]
D0596		Ertapenem	C22H25N3O7S	150610	Minor		Inter Info	[161], [199], [151], [200]
D0635		Famciclovir	C14H19N5O4	3324	Minor		Inter Info	[2]
D0636		Famotidine	C8H15N7O2S3	5702160	Minor		Inter Info	[201]
D0695		Fosinopril	C30H46NO7P	55891	Minor		Inter Info	[185], [186], [187]
D0740		Grepafloxacin	C19H22FN3O3	72474	Minor		Inter Info	[189], [190], [191]
D0938		Lisinopril	C21H31N3O5	5362119	Minor		Inter Info	[185], [186], [187]
D0943		Lomefloxacin	C17H19F2N3O3	3948	Minor		Inter Info	[189], [190], [191]
D1055		Mezlocillin	C21H25N5O8S2	656511	Minor		Inter Info	[179], [180], [181], [182], [183], [184]
D1082		Moexipril	C27H34N2O7	91270	Minor		Inter Info	[185], [186], [187]
D1092		Moxifloxacin	C21H24FN3O4	152946	Minor		Inter Info	[189], [190], [191]
D1099		Nafcillin	C21H22N2O5S	8982	Minor		Inter Info	[179], [180], [181], [182], [183], [184]
D1851		Oseltamivir	C16H28N2O4	65028	Minor		Inter Info	[202]
D1192		Oxacillin	C19H19N3O5S	6196	Minor		Inter Info	[179], [180], [181], [182], [183], [184]
D1256		Perindopril	C19H32N2O5	107807	Minor		Inter Info	[185], [186], [187]
D1268		Phenoxymethylpenicillin	C16H18N2O5S	6869	Minor		Inter Info	[179], [183], [184]
D1296		Piperacillin	C23H27N5O7S	43672	Minor		Inter Info	[179], [180], [181], [182], [183], [184]
D0073		Amoxicillin	C16H19N3O5S	33613	Minor		Inter Info	[179], [180], [181], [182], [183], [184]
D0141		Bacampicillin	C21H27N3O7S	441397	Minor		Inter Info	[179], [180], [181], [182], [183], [184]
D0167		Benzylpenicillin	C16H18N2O4S	5904	Minor		Inter Info	[179], [183], [184]
D0168		Benzylpenicillin (potassium)	C16H18N2O4S	5904	Minor		Inter Info	[179], [183], [184]
D0169		Benzylpenicillin (sodium)	C16H18N2O4S	5904	Minor		Inter Info	[179], [183], [184]
D0254		Captopril	C9H15NO3S	44093	Minor		Inter Info	[185], [186], [187]
D0369		Cloxacillin	C19H18ClN3O5S	6098	Minor		Inter Info	[179], [180], [181], [182], [183], [184]
D0438		Delafloxacin	C18H12ClF3N4O4	487101	Minor		Inter Info	[189], [190], [191]
D0712		Gatifloxacin	C19H22FN3O4	5379	Minor		Inter Info	[189], [190], [191]
D0716		Gemifloxacin	C18H20FN5O4	9571107	Minor		Inter Info	[189], [190], [191]
D0794		Imipenem	C12H17N3O4S	104838	Minor		Inter Info	[161], [204], [151]
D0912		Levetiracetam	C8H14N2O2	5284583	Minor		Inter Info	[205], [206], [207]
D0919		Levofloxacin	C18H20FN3O4	149096	Minor		Inter Info	[189], [190], [191]
D1044		Meticillin	C17H20N2O6S	6087	Minor		Inter Info	[179], [183], [184]
D1155		Norfloxacin	C16H18FN3O3	4539	Minor		Inter Info	[189], [190], [191]
D1165		Ofloxacin	C18H20FN3O4	4583	Minor		Inter Info	[189], [190], [191]
D1499		Sparfloxacin	C19H22F2N4O3	60464	Minor		Inter Info	[189], [190], [191]
D1580		Ticarcillin	C15H16N2O6S2	36921	Minor		Inter Info	[179], [180], [181], [182], [183], [184]
D1369		Quinapril	C25H30N2O5	54892	Minor		Inter Info	[185], [186], [187]
D1379		Ramipril	C23H32N2O5	5362129	Minor		Inter Info	[185], [186], [187]
D1618		Trandolapril	C24H34N2O5	5484727	Minor		Inter Info	[185], [186], [187]
D1657		Trovafloxacin	C20H15F3N4O3	62959	Minor		Inter Info	[189], [190], [191]
D1672		Valaciclovir	C13H20N6O4	135398742	Minor		Inter Info	[208], [209], [210]
	Increased renal excretion (Unspecific)					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0040		Allopurinol	C5H4N4O	135401907	Minor		Inter Info	[175], [176], [177]
	Decreased renal excretion (Unspecific)					Drug Num: 4
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0732		Glycerol phenylbutyrate	C33H38O6	10482134	Major		Inter Info	[8], [9]
D1275		Phenylbutyric acid	C10H12O2	4775	Major		Inter Info	[12], [8], [9]
D1245		Penicillamine	C5H11NO2S	5852	Moderate		Inter Info	[157]
D0544		Dyphylline	C10H14N4O4	3182	Minor		Inter Info	[196], [197], [198]
Pharmacodynamic additive effects
	Increased risk of bleeding					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0753		Heparin	C26H42N2O37S5	772	Minor		Inter Info	[203]
	Increased risk of hypoglycemia					Drug Num: 9
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0013		Acetohexamide	C15H20N2O4S	1989	Moderate		Inter Info	[13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113]
D0325		Chlorpropamide	C10H13ClN2O3S	2727	Moderate		Inter Info	[13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113]
D0727		Glimepiride	C24H34N4O5S	3476	Moderate		Inter Info	[13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113]
D0730		Glyburide	C23H28ClN3O5S	3488	Moderate		Inter Info	[13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113]
D1112		Nateglinide	C19H27NO3	5311309	Moderate		Inter Info	[13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113]
D0728		Glipizide	C21H27N5O4S	3478	Moderate		Inter Info	[13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113]
D1603		Tolbutamide	C12H18N2O3S	5505	Moderate		Inter Info	[13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113]
D1392		Repaglinide	C27H36N2O4	65981	Moderate		Inter Info	[13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113]
D1601		Tolazamide	C14H21N3O3S	5503	Moderate		Inter Info	[13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113]
	Potentiated the pharmacological effects (Unspecific)					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0011		Acetaminophen	C8H9NO2	1983	Minor		Inter Info	[173], [174]
	Increased risk of other adverse reactions (Unspecific)					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0882		Ketorolac	C15H13NO3	3826	Major		Inter Info	[1], [2], [3]
Pharmacodynamic antagonistic effects
	Antagonize the effect of uricosuric agents					Drug Num: 9
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1860		Pegloticase	NA	NA	Major		Inter Info	[10]
D0017		Acetylsalicylic acid	C9H8O4	2244	Moderate		Inter Info	[2], [114], [115]
D0780		Hydroxyurea	CH4N2O2	3657	Moderate		Inter Info	[1], [149]
D0187		Bismuth subsalicylate	C7H6BiO4	16682734	Moderate		Inter Info	[2], [159], [114], [115]
D0331		Choline salicylate	C12H19NO4	54686350	Moderate		Inter Info	[2], [159], [114], [115]
D1272		Phenyl salicylate	C13H10O3	8361	Moderate		Inter Info	[2], [114], [115]
D1442		Salsalate	C14H10O5	5161	Moderate		Inter Info	[2], [159], [114], [115]
D1364		Pyrazinamide	C5H5N3O	1046	Moderate		Inter Info	[166], [2]
D1439		Salicylic acid (sodium)	C7H6O3	338	Moderate		Inter Info	[2], [114], [115]

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76	Product Information. Amaryl (glimepiride). Hoechst Marion-Roussel Inc, Kansas City, MO.
77	Product Information. Apidra (insulin glulisine). Aventis Pharmaceuticals, Bridgewater, NJ.
78	Product Information. Diabeta (glyburide). Hoechst Marion-Roussel Inc, Kansas City, MO.
79	Product Information. Diabinese (chlorpropamide). Pfizer US Pharmaceuticals, New York, NY.
80	Product Information. Dymelor (acetohexamide) Lilly, Eli and Company, Indianapolis, IN.
81	Product Information. Glucotrol (glipizide). Pfizer US Pharmaceuticals, New York, NY.
82	Product Information. Increlex (mecasermin). Tercica Inc, Brisbane, CA.
83	Product Information. Micronase (glyburide). Pharmacia and Upjohn, Kalamazoo, MI.
84	Product Information. Orinase (tolbutamide) Pharmacia and Upjohn, Kalamazoo, MI.
85	Product Information. Prandin (repaglinide). Novo Nordisk Pharmaceuticals Inc, Princeton, NJ.
86	Product Information. Starlix (nateglinide) Novartis Pharmaceuticals, East Hanover, NJ.
87	Product Information. Tolinase (tolazamide) Pharmacia and Upjohn, Kalamazoo, MI.
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200	Product Information. Primaxin (imipenem-cilastatin). Merck & Company Inc, West Point, PA.
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207	Product Information. Keppra (levetiracetam) UCB Pharma Inc, Smyrna, GA.
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