Drug General Information (ID: DDI4AS7H9W)
Drug Name			Valaciclovir		Drug Info		Probenecid		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antiviral Agents				Uricosuric Agents
Structure

Mechanism of Valaciclovir-Probenecid Interaction (Severity Level: Minor)
Competitive inhibition of renal tubular secretion Click to Show/Hide Mechanism Graph
Drug Name		Valaciclovir				Probenecid
Mechanism		Valaciclovir				Competitive inhibition of renal tubular secretion of acyclovir/valacyclovir/famciclovir
Key Mechanism Factor 1
		Factor Name		Renal tubular secretion
		Factor Description		Renal tubular secretion allows selective transfer of substances from the blood around the capillaries into the renal tubules via filtrate. Drug excretion may be reduced when two drugs compete for renal tubular secretion.
Mechanism Description		Decreased elimination of Valaciclovir caused by Probenecid mediated competitive inhibition of renal tubular secretion

References
1	Laskin OL, de Miranda P, King DH, et al "Effects of probenecid on the pharmacokinetics and elimination of acyclovir in humans." Antimicrob Agents Chemother 21 (1982): 804-7. [PMID: 7103460]
2	Product Information. Valtrex (valacyclovir). Glaxo Wellcome, Research Triangle Park, NC.
3	Soul-Lawton JH, Weatherley BC, Posner J, Layton G, Peck RW. Lack of interaction between valaciclovir, the L-valyl ester of aciclovir, and digoxin.?Br J Clin Pharmacol. 1998;45(1):87-89. [PMID: 9489600]