Drug General Information (ID: DDI1H0BI39)
Drug Name			Probenecid		Drug Info		Phenylacetic acid		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Uricosuric Agents				Antihyperammonia Agents
Structure

Mechanism of Probenecid-Phenylacetic acid Interaction (Severity Level: Moderate)
Competitive inhibition of renal tubular secretion Click to Show/Hide Mechanism Graph
Drug Name		Probenecid				Phenylacetic acid
Mechanism		Inhibition of the renal tubular secretion of phenylacetic acid				Phenylacetic acid
Key Mechanism Factor 1
		Factor Name		Renal tubular secretion
		Factor Description		Renal tubular secretion allows selective transfer of substances from the blood around the capillaries into the renal tubules via filtrate. Drug excretion may be reduced when two drugs compete for renal tubular secretion.
Mechanism Description		Decreased elimination of Phenylacetic acid caused by Probenecid mediated competitive inhibition of renal tubular secretion

Recommended Action
Management		Although the interaction is theoretical and no data are available, it may be appropriate to avoid using probenecid during treatment of acute hyperammonemia in patients with urea cycle disorders due to the urgent nature of the condition. Uncontrolled hyperammonemia can rapidly result in brain damage or death.

References
1	Product Information. Ammonul (sodium benzoate-sodium phenylacetate). Ucyclyd Pharma, Scottsdale, AZ.