Drug General Information (ID: DDIL56DPEN)
Drug Name			Famciclovir		Drug Info		Probenecid		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antiviral Agents				Uricosuric Agents
Structure

Mechanism of Famciclovir-Probenecid Interaction (Severity Level: Minor)
Competitive inhibition of renal tubular secretion Click to Show/Hide Mechanism Graph
Drug Name		Famciclovir				Probenecid
Mechanism		Famciclovir				Competitive inhibition of renal tubular secretion of acyclovir/valacyclovir/famciclovir
Key Mechanism Factor 1
		Factor Name		Renal tubular secretion
		Factor Description		Renal tubular secretion allows selective transfer of substances from the blood around the capillaries into the renal tubules via filtrate. Drug excretion may be reduced when two drugs compete for renal tubular secretion.
Mechanism Description		Decreased elimination of Famciclovir caused by Probenecid mediated competitive inhibition of renal tubular secretion

References
1	Cerner Multum, Inc. "UK Summary of Product Characteristics.".