Details of Drug

Details of Drug

 Drug General Information (ID: D0635)
  Drug Name
Famciclovir
  Drug Type Small molecule
  Drug Synonymous
FCV; Famciclovirum; Famvir; Oravir; BRL 42810; IN1338; Anti-Farnesyl Rabbit pAb; BRL-42810; Famciclovirum [INN-Latin]; Famvir (TN); Famciclovir [USAN:BAN:INN]; Famciclovir (JAN/USAN/INN); [2-(acetyloxymethyl)-4-(2-aminopurin-9-yl)butyl] acetate; Diacetyl 6-deoxy-9-(4-hydroxy-3-hydroxymethyl-but-1-yl)guanine; 1,3-Propanediol, 2-(2-(2-amino-9H-purin-9-yl)ethyl)-, diacetate (ester); 2-(2-(2-Amino-9H-purin-9-yl)ethyl)-1,3-propanediol diacetate (ester); 2-(2-(2-amino-9H-purin-9-yl)ethyl)-1,3-propanediol diacetate; 2-(acetoxymethyl)-4-(2-amino-4,5-dihydro-9H-purin-9-yl)butyl acetate; 2-[(acetyloxy)methyl]-4-(2-amino-9H-purin-9-yl)butyl acetate; 2-[2-(2-amino-9H-purin-9-yl)ethyl]-1,3-propanediol diacetate; 9-(4-acetoxy-3-(acetoxymethyl)but-1-yl)-2-aminopurine; 9-[4-acetoxy-3-(acetoxymethyl)but-1-yl]-2-aminopurine
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  Disease Class 1A24-1D9Z: Virus infection
  Therapeutic Class Antiviral Agents
  Structure Could Not Find 2D Structure
3D Structure 2D Structure
  Formula C14H19N5O4
  InChI 1S/C14H19N5O4/c1-9(20)22-6-11(7-23-10(2)21)3-4-19-8-17-12-5-16-14(15)18-13(12)19/h5,8,11H,3-4,6-7H2,1-2H3,(H2,15,16,18)
  InChIKey GGXKWVWZWMLJEH-UHFFFAOYSA-N
  Canonical SMILES CC(=O)OCC(CCN1C=NC2=CN=C(N=C21)N)COC(=O)C
  External Link
Pubchem ID 3324
CAS Number 104227-87-4
CHEBI ID 4974
TTD ID D0VT8P
INTEDE ID DR0679
VARIDT ID DR01431

Drug-Drug Interaction Network
  Sunburst Graph
AM005  Affected excretion pathways
AM007  Pharmacodynamic antagonistic effects
BM028  Competitive inhibition of renal tubular secretion
BM100  Antagonize the effect of vaccine/toxoid
BM107  Attenuated pharmacological effects (Unspecific)
  Relation Graph
 Full list of drugs interacting with Famciclovir
      Affected excretion pathways
   Competitive inhibition of renal tubular secretion Drug Num:  3
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0576
 
Entecavir
 
C12H15N5O3
 
135398508 
Moderate    Inter Info   
[6]
D1241
 
Pemetrexed
 
C20H21N5O6
 
135410875 
Moderate    Inter Info   
[7]
D1341
 
Probenecid
 
C13H19NO4S
 
4911 
Minor    Inter Info   
[3]
      Pharmacodynamic antagonistic effects
   Antagonize the effect of vaccine/toxoid Drug Num:  2
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D1920
 
Varicella Zoster Vaccine (Recombinant)
 
NA
 
NA
Major    Inter Info   
[1], [2]
D1897
 
Talimogene laherparepvec
 
NA
 
NA
Moderate    Inter Info   
[8]
   Attenuated pharmacological effects (Unspecific) Drug Num:  1
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0348
 
Cladribine
 
C10H12ClN5O3
 
20279 
Moderate    Inter Info   
[3], [4], [5]
References
1 US Centers for Disease Control and Prevention (CDC) "Recommended immunization schedule for adults aged 19 years or older, United States, 2017.".
2 Product Information. Zovirax (acyclovir). Mylan Pharmaceuticals Inc, Morgantown, WV.
3 Cerner Multum, Inc. "UK Summary of Product Characteristics.".
4 EMEA. European Medicines Agency "EPARs. European Union Public Assessment Reports.".
5 Product Information. Leustatin (cladribine). Ortho Biotech Inc, Raritan, NJ.
6 Product Information. Baraclude (entecavir). Bristol-Myers Squibb, Princeton, NJ.
7 Product Information. Alimta (pemetrexed). Lilly, Eli and Company, Indianapolis, IN.
8 Product Information. Imlygic (talimogene laherparepvec). Amgen USA, Thousand Oaks, CA.