Drug General Information (ID: DDI6VTIQPN)
Drug Name			Probenecid		Drug Info		Heparin		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Uricosuric Agents				Anticoagulants
Structure

Mechanism of Probenecid-Heparin Interaction (Severity Level: Minor)
Increased risk of bleeding Click to Show/Hide Mechanism Graph
Drug Name		Probenecid				Heparin
Mechanism		Risk of bleeding				Risk of bleeding Anticoagulant
Key Mechanism Factor 1
		Factor Name		Bleeding
		Factor Description		Patients may be at risk for bleeding when the outcome of a disease or disease treatment confounds the standard mechanisms for maintaining hemostasis. Signs or symptoms of abnormal bleeding include: bleeding that takes a long time to stop (including nosebleeds, bleeding gums, bleeding from cuts and abrasions, and menstrual bleeding); severe unexplained bruising, or bruising that becomes larger; blood in the urine or stool, etc.
Mechanism Description		Increased risk of bleeding by the combination of Probenecid and Heparin

References
1	Sanchez G "Enhancement of heparin effect by probenicid." N Engl J Med 292 (1975): 48. [PMID: 1109193]