Details of Drug

Drug General Information (ID: D0753)
Drug Name	Heparin
Drug Type	Small molecule
Drug Synonymous	Arteven; Bemiparin; Certoparin; Clivarine; Dalteparin; Eparina; Fluxum; Fraxiparin; Heparina; Heparinate; Heparine; Heparinum; Hepathrom; Innohep; Liquaemin; Liquemin; Logiparin; Multiparin; Nadroparin; Nadroparine; Novoheparin; Pabyrin; Parnaparin; Parvoparin; Pularin; Sandoparin; Subeparin; Sublingula; Thromboliquine; Tinzaparin; Triofiban; Vetren; Allocinnamic acid; Ardeparin sodium; Bemiparin sodium; Enoxaparin sodium; Eparina [DCIT]; Fragmin A; Fragmin B; Fragmin IV; Hep Flush Kit in plastic container; Heparin Lock Flush in plastic container; Heparin Lock Flush preservative free; Heparin Lock Flush preservative free in plastic container; Heparin natrium; Heparin sulfate; Heparinic acid; Heparinum natricum; Isocinnamic acid; Minolteparin sodium; Parnaparin sodium; Reviparin sodium; Sodium acid heparin; Sodium heparinate; Tinzaparin sodium; Vitrum AB; CY 216; Cy 222; FR 860; H 2149; Heparin CY 216; KB 101; Kabi 2165; LHN 1; Lioton 1000; OP 386; OP 622; Ro 11; WY 90493RD; ALFA 87-120; ALFA 87-163; ALFA 87-198; ALFA 87-81; ALFA 88-247; Alpha-Heparin; Cis-Cinnamic acid; Depo-Heparin; Hed-heparin; Hep-Lock; Heparin, sodium salt; Heparina [INN-Spanish]; Heparine [INN-French]; Heparinum [INN-Latin]; Hepflush-10; Inno-Hep; Normiflo (TN); Hep-Lock U/P; Cis-.beta.-Carboxystyrene Click to Show/Hide
Disease Class	BA43: Coronary thrombosis; DB61-GB90: Thrombosis; BD71: Deep vein thrombosis; BD72: Venous thromboembolism
Therapeutic Class	Anticoagulants
Structure
Structure	3D Structure		2D Structure
Formula	C26H42N2O37S5
InChI	1S/C26H42N2O37S5/c1-4(30)27-7-9(31)13(6(56-23(7)39)3-55-67(43,44)45)58-26-19(65-70(52,53)54)12(34)16(20(62-26)22(37)38)60-24-8(28-66(40,41)42)15(63-68(46,47)48)14(5(2-29)57-24)59-25-18(64-69(49,50)51)11(33)10(32)17(61-25)21(35)36/h5-20,23-26,28-29,31-34,39H,2-3H2,1H3,(H,27,30)(H,35,36)(H,37,38)(H,40,41,42)(H,43,44,45)(H,46,47,48)(H,49,50,51)(H,52,53,54)
InChIKey	HTTJABKRGRZYRN-UHFFFAOYSA-N
Canonical SMILES	CC(=O)NC1C(C(C(OC1O)COS(=O)(=O)O)OC2C(C(C(C(O2)C(=O)O)OC3C(C(C(C(O3)CO)OC4C(C(C(C(O4)C(=O)O)O)O)OS(=O)(=O)O)OS(=O)(=O)O)NS(=O)(=O)O)O)OS(=O)(=O)O)O
External Link
	Pubchem ID	772
	CAS Number	9005-49-6
	TTD ID	D01ZJK
	INTEDE ID	DR0806

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM003 Affected organization distribution AM006 Pharmacodynamic additive effects AM007 Pharmacodynamic antagonistic effects BM013 Competitive binding of plasma proteins BM014 Interference of cell/tissue uptake BM050 Increased risk of bleeding BM058 Increased risk of hyperkalemia BM064 Increased risk of hypoglycemia BM085 Antagonize the effect of antithrombotic agents BM107 Attenuated pharmacological effects (Unspecific)
Relation Graph

Full list of drugs interacting with Heparin
Affected organization distribution
	Competitive binding of plasma proteins					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0491		Digoxin	C41H64O14	2724385	Minor		Inter Info	[314], [315]
	Interference of cell/tissue uptake					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1822		Iodide I-123	I-	135300	Moderate		Inter Info	[288], [289], [290]
Pharmacodynamic additive effects
	Increased risk of bleeding					Drug Num: 148
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0005		Abciximab	NA	NA	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8]
D0047		Alteplase	NA	NA	Major		Inter Info	[9], [10], [3], [11], [12], [13], [14], [15], [16], [17], [18], [19]
D0088		Anistreplase	NA	NA	Major		Inter Info	[9], [10], [3], [11], [12], [13], [14], [15], [16], [17], [18], [19]
D0102		Ardeparin	C26H42N2O37S5	772	Major		Inter Info	[20], [21], [22], [23], [24], [25], [26]
D0104		Argatroban	C23H36N6O5S	92722	Major		Inter Info	[27], [28]
D0189		Bivalirudin	C98H138N24O33	16129704	Major		Inter Info	[29]
D0481		Dicoumarol	C19H12O6	54676038	Major		Inter Info	[30], [31], [32]
D0537		Drotrecogin alfa	NA	NA	Major		Inter Info	[33]
D0588		Eptifibatide	C35H49N11O9S2	448812	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8]
D0690		Fondaparinux	C31H53N3O49S8	5282448	Major		Inter Info	[20], [21], [22], [23], [24], [25], [26]
D0008		Acalabrutinib	C26H23N7O2	71226662	Major		Inter Info	[34]
D0087		Anisindione	C16H12O3	2197	Major		Inter Info	[31], [32]
D0096		Apixaban	C25H25N5O4	10182969	Major		Inter Info	[35], [36]
D0129		Avapritinib	C26H27FN10	118023034	Major		Inter Info	[35], [37]
D0176		Betrixaban	C23H22ClN5O3	10275777	Major		Inter Info	[38]
D0230		Cabozantinib	C28H24FN3O5	25102847	Major		Inter Info	[39]
D0247		Cangrelor	C17H25Cl2F3N5O12P3S2	9854012	Major		Inter Info	[35], [40]
D0250		Caplacizumab	NA	NA	Major		Inter Info	[41], [35], [42]
D0414		Dalteparin	C26H42N2O37S5	772	Major		Inter Info	[20], [21], [22], [23], [24], [25], [26]
D0415		Danaparoid	NA	NA	Major		Inter Info	[20], [21], [22], [23], [24], [25], [26]
D0428		Dasatinib	C22H26ClN7O2S	3062316	Major		Inter Info	[43]
D0432		Deferasirox	C21H15N3O4	214348	Major		Inter Info	[44], [45]
D0435		Defibrotide	C20H21N4O6P	135565962	Major		Inter Info	[35], [46]
D0447		Desirudin	C287H440N80O110S6	16129703	Major		Inter Info	[47]
D0551		Edoxaban	C24H30ClN7O4S	10280735	Major		Inter Info	[48]
D0574		Enoxaparin	C26H42N2O37S5	772	Major		Inter Info	[20], [21], [22], [23], [24], [25], [26]
D0785		Ibrutinib	C25H24N6O2	24821094	Major		Inter Info	[49], [50], [35], [51]
D0805		Inotersen	C230H318N69O121P19S19	121492004	Major		Inter Info	[35], [44], [52]
D0841		Ipilimumab	NA	NA	Major		Inter Info	[53], [35], [54]
D1174		Omacetaxine mepesuccinate	C29H39NO9	285033	Major		Inter Info	[44], [55]
D1221		Panobinostat	C21H23N3O2	6918837	Major		Inter Info	[41], [35], [57]
D1313		Ponatinib	C29H27F3N6O	24826799	Major		Inter Info	[58]
D1380		Ramucirumab	NA	NA	Major		Inter Info	[59]
D1387		Regorafenib	C21H15ClF4N4O3	11167602	Major		Inter Info	[35], [60], [61]
D1417		Rivaroxaban	C19H18ClN3O5S	9875401	Major		Inter Info	[62]
D1549		Temsirolimus	C56H87NO16	6918289	Major		Inter Info	[64]
D1588		Tinzaparin	C26H42N2O37S5	772	Major		Inter Info	[20], [21], [22], [23], [24], [25], [26]
D1623		Trastuzumab emtansine	NA	NA	Major		Inter Info	[41], [35], [65]
D1705		Vorapaxar	C29H33FN2O4	10077130	Major		Inter Info	[66]
D1718		Zanubrutinib	C27H29N5O3	135565884	Major		Inter Info	[44]
D0784		Ibritumomab tiuxetan	NA	NA	Major		Inter Info	[67]
D0904		Lepirudin	C287H440N80O111S6	118856773	Major		Inter Info	[27], [28]
D1063		Mifepristone	C29H35NO2	55245	Major		Inter Info	[68], [69]
D1395		Reteplase	NA	NA	Major		Inter Info	[9], [10], [3], [11], [12], [13], [14], [15], [16], [17], [18], [19]
D1506		Streptokinase	C11H19NO2	9815560	Major		Inter Info	[9], [10], [3], [11], [12], [13], [14], [15], [16], [17], [18], [19]
D1550		Tenecteplase	NA	NA	Major		Inter Info	[9], [10], [3], [11], [12], [13], [14], [15], [16], [17], [18], [19]
D1592		Tipranavir	C31H33F3N2O5S	54682461	Major		Inter Info	[70]
D1593		Tirofiban	C22H36N2O5S	60947	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8]
D1613		Tositumomab	NA	NA	Major		Inter Info	[71], [72]
D1614		Tositumomab (I-131)	NA	NA	Major		Inter Info	[71], [72]
D1669		Urokinase	NA	NA	Major		Inter Info	[9], [10], [3], [11], [12], [13], [14], [15], [16], [17], [18], [19]
D1711		Warfarin	C19H16O4	54678486	Major		Inter Info	[31], [32]
D0017		Acetylsalicylic acid	C9H8O4	2244	Moderate		Inter Info	[174], [175], [176]
D0033		Alemtuzumab	NA	NA	Moderate		Inter Info	[41], [50], [35], [177]
D0046		Alprostadil	C20H34O5	5280723	Moderate		Inter Info	[49], [41], [35], [178]
D0114		Asparaginase Escherichia coli	NA	NA	Moderate		Inter Info	[180], [41], [35], [181], [182], [183], [184], [185], [186], [187], [188], [189], [190]
D0210		Bromfenac	C15H12BrNO3	60726	Moderate		Inter Info	[200], [174], [20], [175], [201], [176]
D0211		Bromfenac (ophthalmic)	C15H12BrNO3	60726	Moderate		Inter Info	[202], [203], [204]
D0282		Cefmetazole	C15H17N7O5S3	42008	Moderate		Inter Info	[205], [206], [207]
D0298		Celecoxib	C17H14F3N3O2S	2662	Moderate		Inter Info	[208]
D0345		Citalopram	C20H21FN2O	2771	Moderate		Inter Info	[209], [210], [211], [212], [213], [214], [215], [216], [217], [218], [219], [220], [221], [222], [223], [224], [225], [226], [227], [228], [229], [230], [231], [232], [233], [234], [235]
D0384		Collagenase clostridium histolyticum	NA	NA	Moderate		Inter Info	[236]
D0476		Diclofenac	C14H11Cl2NO2	3033	Moderate		Inter Info	[200], [174], [20], [175], [201], [176]
D0477		Diclofenac (ophthalmic)	C14H11Cl2NO2	3033	Moderate		Inter Info	[202], [203], [204]
D0478		Diclofenac (topical)	C14H11Cl2NO2	3033	Moderate		Inter Info	[202], [203], [204]
D0489		Diflunisal	C13H8F2O3	3059	Moderate		Inter Info	[200], [174], [20], [175], [201], [176]
D0539		Duloxetine	C18H19NOS	60835	Moderate		Inter Info	[209], [210], [211], [212], [213], [214], [215], [216], [217], [218], [219], [220], [221], [222], [223], [224], [225], [226], [227], [228], [229], [230], [231], [232], [233], [234], [235]
D0624		Etodolac	C17H21NO3	3308	Moderate		Inter Info	[200], [174], [20], [175], [201], [176]
D0641		Fenfluramine	C12H16F3N	3337	Moderate		Inter Info	[209], [210], [211], [212], [213], [214], [215], [216], [217], [218], [219], [220], [221], [222], [223], [224], [225], [226], [227], [228], [229], [230], [231], [232], [233], [234], [235]
D0645		Fenoprofen	C15H14O3	3342	Moderate		Inter Info	[200], [174], [20], [175], [201], [176]
D0676		Fluoxetine	C17H18F3NO	3386	Moderate		Inter Info	[209], [210], [211], [212], [213], [214], [215], [216], [217], [218], [219], [220], [221], [222], [223], [224], [225], [226], [227], [228], [229], [230], [231], [232], [233], [234], [235]
D0680		Flurbiprofen	C15H13FO2	3394	Moderate		Inter Info	[200], [174], [20], [175], [201], [176]
D0681		Flurbiprofen (ophthalmic)	C15H13FO2	3394	Moderate		Inter Info	[202], [203], [204]
D0687		Fluvoxamine	C15H21F3N2O2	5324346	Moderate		Inter Info	[209], [210], [211], [212], [213], [214], [215], [216], [217], [218], [219], [220], [221], [222], [223], [224], [225], [226], [227], [228], [229], [230], [231], [232], [233], [234], [235]
D0092		Antithrombin Alfa	NA	NA	Moderate		Inter Info	[238]
D0093		Antithrombin III human	NA	NA	Moderate		Inter Info	[239]
D0113		Asparaginase Erwinia chrysanthemi	NA	NA	Moderate		Inter Info	[180], [41], [35], [181], [182], [183], [184], [185], [186], [187], [188], [189], [190]
D0187		Bismuth subsalicylate	C7H6BiO4	16682734	Moderate		Inter Info	[240], [241], [242], [243], [244], [245], [246], [247]
D0232		Calaspargase pegol	NA	NA	Moderate		Inter Info	[180], [41], [35], [181], [182], [183], [184], [185], [186], [187], [188], [189], [190]
D0274		Cefamandole	C18H18N6O5S2	456255	Moderate		Inter Info	[205], [206], [207]
D0284		Cefoperazone	C25H27N9O8S2	44187	Moderate		Inter Info	[205], [206], [207]
D0286		Cefotetan	C17H17N7O8S4	53025	Moderate		Inter Info	[205], [206], [207]
D0331		Choline salicylate	C12H19NO4	54686350	Moderate		Inter Info	[240], [241], [242], [243], [244], [245], [246], [247]
D1769		Deoxycholic acid	C24H40O4	222528	Moderate		Inter Info	[44], [248]
D0451		Desvenlafaxine	C16H25NO2	125017	Moderate		Inter Info	[209], [210], [211], [212], [213], [214], [215], [216], [217], [218], [219], [220], [221], [222], [223], [224], [225], [226], [227], [228], [229], [230], [231], [232], [233], [234], [235]
D0457		Dexfenfluramine	C12H16F3N	66265	Moderate		Inter Info	[209], [210], [211], [212], [213], [214], [215], [216], [217], [218], [219], [220], [221], [222], [223], [224], [225], [226], [227], [228], [229], [230], [231], [232], [233], [234], [235]
D0586		Epoprostenol	C20H32O5	5282411	Moderate		Inter Info	[251], [252], [253]
D0599		Escitalopram	C20H21FN2O	146570	Moderate		Inter Info	[209], [210], [211], [212], [213], [214], [215], [216], [217], [218], [219], [220], [221], [222], [223], [224], [225], [226], [227], [228], [229], [230], [231], [232], [233], [234], [235]
D0711		Garlic	NA	NA	Moderate		Inter Info	[254], [255], [256], [257], [258], [259], [260], [261], [262], [263], [264], [265], [266], [267], [268]
D0721		Ginger	C30H40O6	442138	Moderate		Inter Info	[259], [269], [270], [263], [266]
D0722		Ginkgo biloba	NA	NA	Moderate		Inter Info	[271], [272], [273], [274], [256], [275], [276], [257], [259], [260], [277], [269], [278], [263], [279], [280], [281], [266], [282]
D0723		Ginseng	C42H66O17	420552	Moderate		Inter Info	[283], [257], [259], [284], [260], [285], [263], [266], [286]
D0752		Hemin	C34H32FeN4O4	26945	Moderate		Inter Info	[287]
D0920		Levomilnacipran	C15H22N2O	6917779	Moderate		Inter Info	[209], [210], [211], [212], [213], [214], [215], [216], [217], [218], [219], [220], [221], [222], [223], [224], [225], [226], [227], [228], [229], [230], [231], [232], [233], [234], [235]
D1066		Milnacipran	C15H22N2O	65833	Moderate		Inter Info	[209], [210], [211], [212], [213], [214], [215], [216], [217], [218], [219], [220], [221], [222], [223], [224], [225], [226], [227], [228], [229], [230], [231], [232], [233], [234], [235]
D1123		Nepafenac (ophthalmic)	C15H14N2O2	151075	Moderate		Inter Info	[202], [203], [204]
D1139		Nintedanib	C31H33N5O4	135423438	Moderate		Inter Info	[291]
D1140		Niraparib	C19H20N4O	24958200	Moderate		Inter Info	[35], [292]
D1178		Omega-3 fatty acids	C60H92O6	56842239	Moderate		Inter Info	[35], [293], [294]
D1272		Phenyl salicylate	C13H10O3	8361	Moderate		Inter Info	[242], [243], [247]
D1328		Prasugrel	C20H20FNO3S	6918456	Moderate		Inter Info	[35], [295]
D1442		Salsalate	C14H10O5	5161	Moderate		Inter Info	[240], [241], [242], [243], [244], [245], [246], [247]
D1460		Selumetinib	C17H15BrClFN4O3	10127622	Moderate		Inter Info	[297], [298], [299]
D1894		Sugammadex	C72H112O48S8	6918585	Moderate		Inter Info	[35], [300]
D1522		Sunitinib	C22H27FN4O2	5329102	Moderate		Inter Info	[35], [301], [302]
D1579		Ticagrelor	C23H28F2N6O4S	9871419	Moderate		Inter Info	[35], [303]
D1696		Vilazodone	C26H27N5O2	6918314	Moderate		Inter Info	[209], [210], [211], [212], [213], [214], [215], [216], [217], [218], [219], [220], [221], [222], [223], [224], [225], [226], [227], [228], [229], [230], [231], [232], [233], [234], [235]
D1708		Vortioxetine	C18H22N2S	9966051	Moderate		Inter Info	[209], [210], [211], [212], [213], [214], [215], [216], [217], [218], [219], [220], [221], [222], [223], [224], [225], [226], [227], [228], [229], [230], [231], [232], [233], [234], [235]
D0786		Ibuprofen	C13H18O2	3672	Moderate		Inter Info	[200], [174], [20], [175], [201], [176]
D1815		Icosapent	C20H30O2	446284	Moderate		Inter Info	[35], [293], [294]
D0792		Iloprost	C22H32O4	5311181	Moderate		Inter Info	[251], [252], [253]
D0800		Indomethacin	C19H16ClNO4	3715	Moderate		Inter Info	[200], [174], [20], [175], [201], [176]
D0881		Ketoprofen	C16H14O3	3825	Moderate		Inter Info	[200], [174], [20], [175], [201], [176]
D0882		Ketorolac	C15H13NO3	3826	Moderate		Inter Info	[200], [174], [20], [175], [201], [176]
D0883		Ketorolac (ophthalmic)	C15H13NO3	3826	Moderate		Inter Info	[202], [203], [204]
D0988		Meclofenamic acid	C14H11Cl2NO2	4037	Moderate		Inter Info	[174], [175], [176]
D0991		Mefenamic acid	C15H15NO2	4044	Moderate		Inter Info	[200], [174], [20], [175], [201], [176]
D0995		Meloxicam	C14H13N3O4S2	54677470	Moderate		Inter Info	[200], [174], [20], [175], [201], [176]
D1097		Nabumetone	C15H16O2	4409	Moderate		Inter Info	[200], [174], [20], [175], [201], [176]
D1109		Naproxen	C14H14O3	156391	Moderate		Inter Info	[200], [174], [20], [175], [201], [176]
D1196		Oxaprozin	C18H15NO3	4614	Moderate		Inter Info	[200], [174], [20], [175], [201], [176]
D1229		Paroxetine	C19H20FNO3	43815	Moderate		Inter Info	[209], [210], [211], [212], [213], [214], [215], [216], [217], [218], [219], [220], [221], [222], [223], [224], [225], [226], [227], [228], [229], [230], [231], [232], [233], [234], [235]
D1234		Pegaspargase	C14H19NO	436058	Moderate		Inter Info	[180], [41], [35], [181], [182], [183], [184], [185], [186], [187], [188], [189], [190]
D1249		Pentosan polysulfate	C10H18O21S4	37720	Moderate		Inter Info	[44], [308]
D1251		Pentoxifylline	C13H18N4O3	4740	Moderate		Inter Info	[309], [310]
D1274		Phenylbutazone	C19H20N2O2	4781	Moderate		Inter Info	[200], [174], [20], [175], [201], [176]
D1300		Piroxicam	C15H13N3O4S	54676228	Moderate		Inter Info	[200], [174], [20], [175], [201], [176]
D1421		Rofecoxib	C17H14O4S	5090	Moderate		Inter Info	[208]
D1439		Salicylic acid (sodium)	C7H6O3	338	Moderate		Inter Info	[242], [243], [247]
D1461		Sertraline	C17H17Cl2N	68617	Moderate		Inter Info	[209], [210], [211], [212], [213], [214], [215], [216], [217], [218], [219], [220], [221], [222], [223], [224], [225], [226], [227], [228], [229], [230], [231], [232], [233], [234], [235]
D1464		Sibutramine	C17H26ClN	5210	Moderate		Inter Info	[209], [210], [211], [212], [213], [214], [215], [216], [217], [218], [219], [220], [221], [222], [223], [224], [225], [226], [227], [228], [229], [230], [231], [232], [233], [234], [235]
D1520		Sulindac	C20H17FO3S	1548887	Moderate		Inter Info	[200], [174], [20], [175], [201], [176]
D1523		Suprofen (ophthalmic)	C14H12O3S	5359	Moderate		Inter Info	[202], [203], [204]
D1581		Ticlopidine	C14H14ClNS	5472	Moderate		Inter Info	[311]
D1606		Tolmetin	C15H15NO3	5509	Moderate		Inter Info	[200], [174], [20], [175], [201], [176]
D1625		Treprostinil	C23H34O5	6918140	Moderate		Inter Info	[251], [252], [253]
D1674		Valdecoxib	C16H14N2O3S	119607	Moderate		Inter Info	[208]
D1689		Venlafaxine	C17H27NO2	5656	Moderate		Inter Info	[209], [210], [211], [212], [213], [214], [215], [216], [217], [218], [219], [220], [221], [222], [223], [224], [225], [226], [227], [228], [229], [230], [231], [232], [233], [234], [235]
D0506		Dipyridamole	C24H40N8O4	3108	Minor		Inter Info	[32]
D0253		Capsicum	NA	NA	Minor		Inter Info	[259]
D0276		Cefazolin	C14H14N8O4S3	33255	Minor		Inter Info	[316], [317], [318]
D0287		Cefoxitin	C16H17N3O7S2	441199	Minor		Inter Info	[317], [319]
D0296		Ceftriaxone	C18H18N8O7S3	5479530	Minor		Inter Info	[317], [320]
D0309		Chamomile	C15H10O5	5280443	Minor		Inter Info	[259], [321], [263]
D0336		Cilostazol	C20H27N5O2	2754	Minor		Inter Info	[32]
D0368		Clove	NA	NA	Minor		Inter Info	[259], [322], [323], [324]
D1661		Turmeric	C21H20O6	969516	Minor		Inter Info	[325], [259], [326]
D1341		Probenecid	C13H19NO4S	4911	Minor		Inter Info	[327]
	Increased risk of hyperkalemia					Drug Num: 21
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0058		Amiloride	C6H8ClN7O	16231	Moderate		Inter Info	[35], [41], [179]
D0156		Benazepril	C24H28N2O5	5362124	Moderate		Inter Info	[191], [192], [193], [194], [195], [35], [196], [197], [198], [199]
D0567		Enalapril	C20H28N2O5	5388962	Moderate		Inter Info	[191], [192], [193], [194], [195], [35], [196], [197], [198], [199]
D0695		Fosinopril	C30H46NO7P	55891	Moderate		Inter Info	[191], [192], [193], [194], [195], [35], [196], [197], [198], [199]
D0038		Aliskiren	C30H53N3O6	5493444	Moderate		Inter Info	[179], [60]
D0254		Captopril	C9H15NO3S	44093	Moderate		Inter Info	[191], [192], [193], [194], [195], [35], [196], [197], [198], [199]
D0536		Drospirenone	C24H30O3	68873	Moderate		Inter Info	[249], [250]
D1608		Tolvaptan	C26H25ClN2O3	216237	Moderate		Inter Info	[304]
D0844		Irbesartan	C25H28N6O	3749	Moderate		Inter Info	[192], [191], [35], [196], [199], [194], [198], [195], [197], [193]
D0938		Lisinopril	C21H31N3O5	5362119	Moderate		Inter Info	[192], [191], [35], [196], [199], [194], [198], [195], [197], [193]
D0954		Losartan	C22H23ClN6O	3961	Moderate		Inter Info	[192], [191], [35], [196], [199], [194], [198], [195], [197], [193]
D1082		Moexipril	C27H34N2O7	91270	Moderate		Inter Info	[192], [191], [35], [196], [199], [194], [198], [195], [197], [193]
D1170		Olmesartan	C24H26N6O3	158781	Moderate		Inter Info	[192], [191], [35], [196], [199], [194], [198], [195], [197], [193]
D1256		Perindopril	C19H32N2O5	107807	Moderate		Inter Info	[192], [191], [35], [196], [199], [194], [198], [195], [197], [193]
D1369		Quinapril	C25H30N2O5	54892	Moderate		Inter Info	[192], [191], [35], [196], [199], [194], [198], [195], [197], [193]
D1379		Ramipril	C23H32N2O5	5362129	Moderate		Inter Info	[192], [191], [35], [196], [199], [194], [198], [195], [197], [193]
D1501		Spironolactone	C24H32O4S	5833	Moderate		Inter Info	[35], [41], [179]
D1545		Telmisartan	C33H30N4O2	65999	Moderate		Inter Info	[192], [191], [35], [196], [199], [194], [198], [195], [197], [193]
D1618		Trandolapril	C24H34N2O5	5484727	Moderate		Inter Info	[192], [191], [35], [196], [199], [194], [198], [195], [197], [193]
D1631		Triamterene	C12H11N7	5546	Moderate		Inter Info	[41], [35], [179]
D1679		Valsartan	C24H29N5O3	60846	Moderate		Inter Info	[192], [191], [35], [196], [199], [194], [198], [195], [197], [193]
	Increased risk of hypoglycemia					Drug Num: 8
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0013		Acetohexamide	C15H20N2O4S	1989	Moderate		Inter Info	[73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113], [114], [115], [116], [117], [118], [119], [120], [121], [122], [123], [124], [125], [126], [127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [137], [138], [139], [140], [141], [142], [143], [144], [145], [146], [147], [148], [149], [150], [151], [152], [153], [154], [155], [156], [157], [158], [159], [160], [161], [162], [163], [164], [165], [166], [167], [168], [169], [170], [171], [172], [173]
D0325		Chlorpropamide	C10H13ClN2O3S	2727	Moderate		Inter Info	[73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113], [114], [115], [116], [117], [118], [119], [120], [121], [122], [123], [124], [125], [126], [127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [137], [138], [139], [140], [141], [142], [143], [144], [145], [146], [147], [148], [149], [150], [151], [152], [153], [154], [155], [156], [157], [158], [159], [160], [161], [162], [163], [164], [165], [166], [167], [168], [169], [170], [171], [172], [173]
D0727		Glimepiride	C24H34N4O5S	3476	Moderate		Inter Info	[73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113], [114], [115], [116], [117], [118], [119], [120], [121], [122], [123], [124], [125], [126], [127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [137], [138], [139], [140], [141], [142], [143], [144], [145], [146], [147], [148], [149], [150], [151], [152], [153], [154], [155], [156], [157], [158], [159], [160], [161], [162], [163], [164], [165], [166], [167], [168], [169], [170], [171], [172], [173]
D0728		Glipizide	C21H27N5O4S	3478	Moderate		Inter Info	[73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113], [114], [115], [116], [117], [118], [119], [120], [121], [122], [123], [124], [125], [126], [127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [137], [138], [139], [140], [141], [142], [143], [144], [145], [146], [147], [148], [149], [150], [151], [152], [153], [154], [155], [156], [157], [158], [159], [160], [161], [162], [163], [164], [165], [166], [167], [168], [169], [170], [171], [172], [173]
D1603		Tolbutamide	C12H18N2O3S	5505	Moderate		Inter Info	[73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113], [114], [115], [116], [117], [118], [119], [120], [121], [122], [123], [124], [125], [126], [127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [137], [138], [139], [140], [141], [142], [143], [144], [145], [146], [147], [148], [149], [150], [151], [152], [153], [154], [155], [156], [157], [158], [159], [160], [161], [162], [163], [164], [165], [166], [167], [168], [169], [170], [171], [172], [173]
D1112		Nateglinide	C19H27NO3	5311309	Moderate		Inter Info	[73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113], [114], [115], [116], [117], [118], [119], [120], [121], [122], [123], [124], [125], [126], [127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [137], [138], [139], [140], [141], [142], [143], [144], [145], [146], [147], [148], [149], [150], [151], [152], [153], [154], [155], [156], [157], [158], [159], [160], [161], [162], [163], [164], [165], [166], [167], [168], [169], [170], [171], [172], [173]
D1392		Repaglinide	C27H36N2O4	65981	Moderate		Inter Info	[73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113], [114], [115], [116], [117], [118], [119], [120], [121], [122], [123], [124], [125], [126], [127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [137], [138], [139], [140], [141], [142], [143], [144], [145], [146], [147], [148], [149], [150], [151], [152], [153], [154], [155], [156], [157], [158], [159], [160], [161], [162], [163], [164], [165], [166], [167], [168], [169], [170], [171], [172], [173]
D1601		Tolazamide	C14H21N3O3S	5503	Moderate		Inter Info	[73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113], [114], [115], [116], [117], [118], [119], [120], [121], [122], [123], [124], [125], [126], [127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [137], [138], [139], [140], [141], [142], [143], [144], [145], [146], [147], [148], [149], [150], [151], [152], [153], [154], [155], [156], [157], [158], [159], [160], [161], [162], [163], [164], [165], [166], [167], [168], [169], [170], [171], [172], [173]
Pharmacodynamic antagonistic effects
	Antagonize the effect of antithrombotic agents					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1146		Nitroglycerin	C3H5N3O9	4510	Moderate		Inter Info	[305], [306], [307]
	Attenuated pharmacological effects (Unspecific)					Drug Num: 6
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1186		Oritavancin	C86H97Cl3N10O26	16136912	Major		Inter Info	[56]
D1542		Telavancin	C80H106Cl2N11O27P	3081362	Major		Inter Info	[63]
D0449		Desmopressin	C46H64N14O12S2	5311065	Moderate		Inter Info	[41], [35], [237]
D1873		Pyrophosphoric acid	H4O7P2	1023	Moderate		Inter Info	[296]
D1683		Vasopressin	C46H65N15O12S2	644077	Moderate		Inter Info	[41], [35], [237]
D1691		Verteporfin	C82H84N8O16	11980904	Moderate		Inter Info	[312], [313]

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136	Product Information. Amaryl (glimepiride). Hoechst Marion-Roussel Inc, Kansas City, MO.
137	Product Information. Apidra (insulin glulisine). Aventis Pharmaceuticals, Bridgewater, NJ.
138	Product Information. Diabeta (glyburide). Hoechst Marion-Roussel Inc, Kansas City, MO.
139	Product Information. Diabinese (chlorpropamide). Pfizer US Pharmaceuticals, New York, NY.
140	Product Information. Dymelor (acetohexamide) Lilly, Eli and Company, Indianapolis, IN.
141	Product Information. Glucotrol (glipizide). Pfizer US Pharmaceuticals, New York, NY.
142	Product Information. Increlex (mecasermin). Tercica Inc, Brisbane, CA.
143	Product Information. Micronase (glyburide). Pharmacia and Upjohn, Kalamazoo, MI.
144	Product Information. Orinase (tolbutamide) Pharmacia and Upjohn, Kalamazoo, MI.
145	Product Information. Prandin (repaglinide). Novo Nordisk Pharmaceuticals Inc, Princeton, NJ.
146	Product Information. Starlix (nateglinide) Novartis Pharmaceuticals, East Hanover, NJ.
147	Product Information. Tolinase (tolazamide) Pharmacia and Upjohn, Kalamazoo, MI.
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186	Product Information. Elspar (asparaginase). Merck & Co, Inc, West Point, PA.
187	Product Information. Erwinaze (asparaginase Erwinia chrysanthemi). EUSA Pharma, Newtown, PA.
188	Product Information. Oncaspar (pegaspargase). Rhone-Poulenc Rorer, Collegeville, PA.
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192	Product Information. Micardis (telmisartan). Boehringer-Ingelheim, Ridgefield, CT.
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221	Product Information. Celexa (citalopram). Forest Pharmaceuticals, St. Louis, MO.
222	Product Information. Cymbalta (duloxetine). Lilly, Eli and Company, Indianapolis, IN.
223	Product Information. Effexor (venlafaxine). Wyeth-Ayerst Laboratories, Philadelphia, PA.
224	Product Information. Fetzima (levomilnacipran). Forest Pharmaceuticals, St. Louis, MO.
225	Product Information. Lexapro (escitalopram). Forest Pharmaceuticals, St. Louis, MO.
226	Product Information. Luvox (fluvoxamine). Solvay Pharmaceuticals Inc, Marietta, GA.
227	Product Information. Paxil (paroxetine). GlaxoSmithKline, Research Triangle Park, NC.
228	Product Information. Pristiq (desvenlafaxine). Wyeth Laboratories, Philadelphia, PA.
229	Product Information. Prozac (fluoxetine). Dista Products Company, Indianapolis, IN.
230	Product Information. Savella (milnacipran). Forest Pharmaceuticals, St. Louis, MO.
231	Product Information. Zoloft (sertraline). Roerig Division, New York, NY.
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237	Product Information. Vasostrict (vasopressin). Par Pharmaceutical Inc, Chestnut Ridge, NY.
238	Product Information. ATryn (antithrombin recombinant). Ovation Pharmaceuticals Inc, Deerfield, IL.
239	Product Information. Thrombate III (antithrombin III). Bayer, West Haven, CT.
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