Drug General Information (ID: DDIPY30N24)
Drug Name			Desmopressin		Drug Info		Heparin		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antidiuretic Hormones				Anticoagulants
Structure

Mechanism of Desmopressin-Heparin Interaction (Severity Level: Moderate)
Attenuated pharmacological effects (Unspecific) Click to Show/Hide Mechanism Graph
Drug Name		Desmopressin				Heparin
Mechanism		Desmopressin				Antagonize the antidiuretic effect and decrease the pressor effect of vasopressin
Key Mechanism Factor 1
		Factor Name		Pharmacodynamics
		Factor Description		Reduced pharmacological effects leading to insufficient efficacy and/or treatment failure.
Mechanism Description		Attenuated pharmacological effects of  Desmopressin when combined with Heparin

Recommended Action
Management		Hemodynamic monitoring is recommended. In addition, vasopressin dosage may be adjusted as needed if co-administered with any of the abovementioned drugs.

References
1	Cerner Multum, Inc. "Australian Product Information.".
2	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
3	Product Information. Vasostrict (vasopressin). Par Pharmaceutical Inc, Chestnut Ridge, NY.