Drug General Information (ID: DDIN1IVLJW)
Drug Name			Heparin		Drug Info		Aliskiren		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Anticoagulants				Antihypertensive Agents
Structure

Mechanism of Heparin-Aliskiren Interaction (Severity Level: Moderate)
Increased risk of hyperkalemia Click to Show/Hide Mechanism Graph
Drug Name		Heparin				Aliskiren
Mechanism		Hyperkalemia				Hyperkalemia
Key Mechanism Factor 1
		Factor Name		Hyperkalemia
		Factor Description		Hyperkalemia is a condition in which the level of potassium in the blood is higher than normal. While mild cases may not produce symptoms, severe hyperkalemia can lead to fatal arrhythmias if left untreated.
Mechanism Description		Increased risk of hyperkalemia by the combination of Heparin and Aliskiren

Recommended Action
Management		Caution is advised if aliskiren is used with heparin or low molecular weight heparin. It may be advisable to monitor serum potassium and renal function.

References
1	Agencia Espaola de Medicamentos y Productos Sanitarios Healthcare "Centro de informacion online de medicamentos de la AEMPS - CIMA.".
2	EMEA. European Medicines Agency "EPARs. European Union Public Assessment Reports.".