Details of Drug

Drug General Information (ID: D0038)
Drug Name	Aliskiren
Drug Type	Small molecule
Drug Synonymous	Rasilez; SPP 100; Rasilez (TN); Tekturna (TN); Aliskiren (USAN/INN); (2S,4S,5S,7S)-5-amino-N-(3-amino-2,2-dimethyl-3-oxopropyl)-4-hydroxy-7-[4-methoxy-3-(3-methoxypropoxy)benzyl]-8-methyl-2-(propan-2-yl)nonanamide; (2S,4S,5S,7S)-5-amino-N-(3-amino-2,2-dimethyl-3-oxopropyl)-4-hydroxy-7-[[4-methoxy-3-(3-methoxypropoxy)phenyl]methyl]-8-methyl-2-propan-2-ylnonanamide; (2S,4S,5S,7S)-N-(2-Carbamoyl-2-methylpropyl)-5-amino-4-hydroxy-2,7-diisopropyl-8-[4-methoxy-3-(3-methoxypropoxy)phenyl]octanamide; Octanamide, .delta.-amino-N-(3-amino-2,2-dimethyl-3-oxopropyl)-.gamma.-hydroxy-4-methoxy-3-(3-methoxypropoxy)-.alpha.,.zeta.-bis(1-methylethyl)-, [.alpha.S-(alpha.R,.gamma.R,.delta.R,.zeta.R)] Click to Show/Hide
Disease Class	BA00-BA04: Hypertension
Therapeutic Class	Antihypertensive Agents
Structure
Structure	3D Structure		2D Structure
Formula	C30H53N3O6
InChI	1S/C30H53N3O6/c1-19(2)22(14-21-10-11-26(38-8)27(15-21)39-13-9-12-37-7)16-24(31)25(34)17-23(20(3)4)28(35)33-18-30(5,6)29(32)36/h10-11,15,19-20,22-25,34H,9,12-14,16-18,31H2,1-8H3,(H2,32,36)(H,33,35)/t22-,23-,24-,25-/m0/s1
InChIKey	UXOWGYHJODZGMF-QORCZRPOSA-N
Canonical SMILES	CC(C)C(CC1=CC(=C(C=C1)OC)OCCCOC)CC(C(CC(C(C)C)C(=O)NCC(C)(C)C(=O)N)O)N
External Link
	Pubchem ID	5493444
	CAS Number	173334-57-1
	CHEBI ID	601027
	TTD ID	D03SVX
	INTEDE ID	DR0065
	VARIDT ID	DR00061

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM002 Affected cellular transport AM004 Affected intra/extra-hepatic metabolism AM006 Pharmacodynamic additive effects AM007 Pharmacodynamic antagonistic effects BM010 Transporter inhibition BM011 Transporter induction BM017 CYP450 enzyme inhibition BM022 CYP450 enzyme induction BM042 Additive hypotensive effects BM048 Increased risk of angioedema/anaphylactoid reactions BM058 Increased risk of hyperkalemia BM089 Antagonize the effect of antihypertensive agents
Relation Graph

Full list of drugs interacting with Aliskiren
Affected cellular transport
	Transporter inhibition					Drug Num: 35
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0402		Cyclosporine	C62H111N11O12	5284373	Major		Inter Info	[2]
D0044		Alpelisib	C19H22F3N5O2S	56649450	Moderate		Inter Info	[11], [12], [2], [9]
D0204		Brigatinib	C29H39ClN7O2P	68165256	Moderate		Inter Info	[11], [12], [2], [9]
D0408		Daclatasvir	C40H50N8O6	25154714	Moderate		Inter Info	[11], [12], [2], [9]
D0559		Eliglustat	C23H36N2O4	23652731	Moderate		Inter Info	[11], [12], [2], [9]
D0569		Encorafenib	C22H27ClFN7O4S	50922675	Moderate		Inter Info	[12], [20]
D0590		Erdafitinib	C25H30N6O2	67462786	Moderate		Inter Info	[21]
D0720		Gilteritinib	C29H44N8O3	49803313	Moderate		Inter Info	[11], [12], [2], [9]
D0725		Glasdegib	C21H22N6O	25166913	Moderate		Inter Info	[11], [12], [2], [9]
D0726		Glecaprevir	C38H46F4N6O9S	66828839	Moderate		Inter Info	[11], [12], [9]
D0785		Ibrutinib	C25H24N6O2	24821094	Moderate		Inter Info	[12], [23]
D0897		Lasmiditan	C19H18F3N3O2	11610526	Moderate		Inter Info	[25]
D0898		Ledipasvir	C49H54F2N8O6	67505836	Moderate		Inter Info	[11], [12], [9]
D1124		Neratinib	C30H29ClN6O3	9915743	Moderate		Inter Info	[11], [12], [2], [9]
D1423		Rolapitant	C25H26F6N2O2	10311306	Moderate		Inter Info	[49]
D1445		Sarecycline	C24H29N3O8	54681908	Moderate		Inter Info	[11], [12], [2], [9]
D1524		Suvorexant	C23H23ClN6O2	24965990	Moderate		Inter Info	[11], [12], [2], [9]
D1673		Valbenazine	C24H38N2O4	24795069	Moderate		Inter Info	[11], [12], [2], [9]
D1686		Velpatasvir	C49H54N8O8	67683363	Moderate		Inter Info	[11], [12], [9]
D1710		Voxilaprevir	C40H52F4N6O9S	89921642	Moderate		Inter Info	[11], [12], [9]
D0139		Azithromycin	C38H72N2O12	447043	Moderate		Inter Info	[11], [12], [2], [9]
D0170		Bepridil	C24H34N2O	2351	Moderate		Inter Info	[11], [12], [2], [9]
D0230		Cabozantinib	C28H24FN3O5	25102847	Moderate		Inter Info	[11], [12], [2], [9]
D0267		Carvedilol	C24H26N2O4	2585	Moderate		Inter Info	[11], [12], [2], [9]
D0313		Chloramphenicol	C11H12Cl2N2O5	5959	Moderate		Inter Info	[11], [12], [2], [9]
D0640		Felodipine	C18H19Cl2NO4	3333	Moderate		Inter Info	[11], [12], [2], [9]
D1062		Midostaurin	C35H30N4O4	9829523	Moderate		Inter Info	[12]
D1134		Nifedipine	C17H18N2O6	4485	Moderate		Inter Info	[11], [12], [2], [9]
D1313		Ponatinib	C29H27F3N6O	24826799	Moderate		Inter Info	[11], [12], [2], [9]
D1353		Propafenone	C21H27NO3	4932	Moderate		Inter Info	[11], [12], [2], [9]
D1371		Quinidine	C20H24N2O2	441074	Moderate		Inter Info	[12]
D1526		Tacrolimus	C44H69NO12	445643	Moderate		Inter Info	[11], [12], [2], [9]
D1664		Ulipristal	C28H35NO3	13559281	Moderate		Inter Info	[11], [12], [2], [9]
D1681		Vandetanib	C22H24BrFN4O2	3081361	Moderate		Inter Info	[11], [12], [2], [9]
D1687		Vemurafenib	C23H18ClF2N3O3S	42611257	Moderate		Inter Info	[11], [12], [2], [9]
	Transporter induction					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1400		Rifampicin	C43H58N4O12	135398735	Minor		Inter Info	[12], [13], [78]
D1502		St. John's Wort	NA	NA	Minor		Inter Info	[12], [59]
Affected intra/extra-hepatic metabolism
	CYP450 enzyme inhibition					Drug Num: 70
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0867		Itraconazole	C35H38Cl2N8O4	55283	Major		Inter Info	[7], [8], [2], [9]
D0007		Abiraterone	C24H31NO	132971	Moderate		Inter Info	[11], [12], [2], [9]
D0002		Abametapir (topical)	C12H12N2	15664	Moderate		Inter Info	[15]
D0251		Capmatinib	C23H17FN6O	25145656	Moderate		Inter Info	[11], [12], [2], [9]
D0302		Ceritinib	C28H36ClN5O3S	57379345	Moderate		Inter Info	[11], [12], [2], [9]
D0375		Cobicistat	C40H53N7O5S2	25151504	Moderate		Inter Info	[11], [12], [2], [9]
D0543		Duvelisib	C22H17ClN6O	50905713	Moderate		Inter Info	[11], [12], [2], [9]
D0638		Fedratinib	C27H36N6O3S	16722836	Moderate		Inter Info	[11], [12], [2], [9]
D0696		Fosnetupitant	C31H35F6N4O5P	71544786	Moderate		Inter Info	[11], [12], [9]
D0699		Fostamatinib	C23H26FN6O9P	11671467	Moderate		Inter Info	[22]
D0789		Idelalisib	C22H18FN7O	11625818	Moderate		Inter Info	[11], [12], [2], [9]
D0866		Istradefylline	C20H24N4O4	5311037	Moderate		Inter Info	[11], [12], [2], [9]
D0896		Larotrectinib	C21H22F2N6O2	46188928	Moderate		Inter Info	[7], [12], [24]
D0899		Lefamulin	C28H45NO5S	25185057	Moderate		Inter Info	[26]
D0906		Letermovir	C29H28F4N4O4	45138674	Moderate		Inter Info	[11], [12], [2], [9]
D1127		Netupitant	C30H32F6N4O	6451149	Moderate		Inter Info	[11], [12], [9]
D1398		Ribociclib	C23H30N8O	44631912	Moderate		Inter Info	[11], [12], [2], [9]
D1432		Rucaparib	C19H18FN3O	9931954	Moderate		Inter Info	[50]
D1459		Selpercatinib	C29H31N7O3	134436906	Moderate		Inter Info	[11], [12], [2], [9]
D1505		Stiripentol	C14H18O3	5311454	Moderate		Inter Info	[11], [12], [2], [9]
D1653		Troleandomycin	C41H67NO15	202225	Moderate		Inter Info	[11], [12], [2], [9]
D1660		Tucatinib	C26H24N8O2	51039094	Moderate		Inter Info	[11], [12], [2], [9]
D1709		Voxelotor	C19H19N3O3	71602803	Moderate		Inter Info	[11], [12], [2], [9]
D0066		Amiodarone	C25H29I2NO3	2157	Moderate		Inter Info	[11], [12], [2], [9]
D0080		Amprenavir	C25H35N3O6S	65016	Moderate		Inter Info	[11], [12], [2], [9]
D0100		Aprepitant	C23H21F7N4O3	135413536	Moderate		Inter Info	[11], [12], [2], [9]
D0116		Atazanavir	C38H52N6O7	148192	Moderate		Inter Info	[11], [12], [2], [9]
D0120		Atorvastatin	C33H35FN2O5	60823	Moderate		Inter Info	[2]
D0192		Boceprevir	C27H45N5O5	10324367	Moderate		Inter Info	[11], [12], [2], [9]
D0341		Ciprofloxacin	C17H18FN3O3	2764	Moderate		Inter Info	[11], [12], [2], [9]
D0349		Clarithromycin	C38H69NO13	84029	Moderate		Inter Info	[11], [12], [2], [9]
D0367		Clotrimazole	C22H17ClN2	2812	Moderate		Inter Info	[11], [12], [2], [9]
D0386		Conivaptan	C32H26N4O2	151171	Moderate		Inter Info	[11], [12], [2], [9]
D0393		Crizotinib	C21H22Cl2FN5O	11626560	Moderate		Inter Info	[11], [12], [2], [9]
D0413		Dalfopristin	C34H50N4O9S	6323289	Moderate		Inter Info	[11], [12], [9]
D0426		Darunavir	C27H37N3O7S	213039	Moderate		Inter Info	[11], [12], [2], [9]
D0439		Delavirdine	C22H28N6O3S	5625	Moderate		Inter Info	[11], [12], [2], [9]
D0497		Diltiazem	C22H26N2O4S	39186	Moderate		Inter Info	[11], [12], [2], [9]
D0534		Dronedarone	C31H44N2O5S	208898	Moderate		Inter Info	[11], [12], [2], [9]
D0597		Erythromycin	C37H67NO13	12560	Moderate		Inter Info	[11], [12], [2], [9]
D0665		Flibanserin	C20H21F3N4O	6918248	Moderate		Inter Info	[11], [12], [2], [9]
D0667		Fluconazole	C13H12F2N6O	3365	Moderate		Inter Info	[11], [12], [2], [9]
D0692		Fosamprenavir	C25H36N3O9PS	131536	Moderate		Inter Info	[11], [12], [2], [9]
D0693		Fosaprepitant	C23H22F7N4O6P	135413538	Moderate		Inter Info	[11], [12], [2], [9]
D0793		Imatinib	C29H31N7O	5291	Moderate		Inter Info	[11], [12], [2], [9]
D0799		Indinavir	C36H47N5O4	5362440	Moderate		Inter Info	[11], [12], [2], [9]
D0852		Isavuconazonium	C35H35F2N8O5S+	6918606	Moderate		Inter Info	[11], [12], [2], [9]
D0869		Ivacaftor	C24H28N2O3	16220172	Moderate		Inter Info	[11], [12], [2], [9]
D0880		Ketoconazole	C26H28Cl2N4O4	456201	Moderate		Inter Info	[11], [12], [2], [9]
D0894		Lapatinib	C29H26ClFN4O4S	208908	Moderate		Inter Info	[11], [12], [2], [9]
D0944		Lomitapide	C39H37F6N3O2	9853053	Moderate		Inter Info	[11], [12], [2], [9]
D0946		Lonafarnib	C27H31Br2ClN4O2	148195	Moderate		Inter Info	[11], [12], [2], [9]
D1057		Miconazole	C18H14Cl4N2O	4189	Moderate		Inter Info	[11], [12], [2], [9]
D1063		Mifepristone	C29H35NO2	55245	Moderate		Inter Info	[7], [12], [70], [71]
D1117		Nefazodone	C25H32ClN5O2	4449	Moderate		Inter Info	[11], [12], [2], [9]
D1119		Nelfinavir	C32H45N3O4S	64143	Moderate		Inter Info	[11], [12], [2], [9]
D1136		Nilotinib	C28H22F3N7O	644241	Moderate		Inter Info	[11], [12], [2], [9]
D1315		Posaconazole	C37H42F2N8O4	468595	Moderate		Inter Info	[11], [12], [2], [9]
D1372		Quinine	C20H24N2O2	3034034	Moderate		Inter Info	[11], [12], [2], [9]
D1383		Ranolazine	C24H33N3O4	56959	Moderate		Inter Info	[11], [12], [2], [9]
D1415		Ritonavir	C37H48N6O5S2	392622	Moderate		Inter Info	[11], [12], [2], [9]
D1444		Saquinavir	C38H50N6O5	441243	Moderate		Inter Info	[11], [12], [2], [9]
D1471		Simeprevir	C38H47N5O7S2	24873435	Moderate		Inter Info	[11], [12], [2], [9]
D1497		Sorafenib	C21H16ClF3N4O3	216239	Moderate		Inter Info	[11], [12], [2], [9]
D1541		Telaprevir	C36H53N7O6	3010818	Moderate		Inter Info	[11], [12], [2], [9]
D1544		Telithromycin	C43H65N5O10	3002190	Moderate		Inter Info	[11], [12], [2], [9]
D1579		Ticagrelor	C23H28F2N6O4S	9871419	Moderate		Inter Info	[11], [12], [2], [9]
D1608		Tolvaptan	C26H25ClN2O3	216237	Moderate		Inter Info	[11], [12], [2], [9]
D1690		Verapamil	C27H38N2O4	2520	Moderate		Inter Info	[11], [12], [2], [9]
D1706		Voriconazole	C16H14F3N5O	71616	Moderate		Inter Info	[11], [12], [2], [9]
	CYP450 enzyme induction					Drug Num: 5
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0095		Apalutamide	C21H15F4N5O2S	24872560	Moderate		Inter Info	[12], [16]
D0545		Echinacea	NA	NA	Moderate		Inter Info	[7], [18]
D0953		Lorlatinib	C21H19FN6O2	71731823	Moderate		Inter Info	[30]
D1546		Telotristat ethyl	C27H26ClF3N6O3	25181577	Moderate		Inter Info	[12], [53]
D0578		Enzalutamide	C21H16F4N4O2S	15951529	Moderate		Inter Info	[63], [7], [12], [64]
Pharmacodynamic additive effects
	Additive hypotensive effects					Drug Num: 29
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1596		Tizanidine	C9H8ClN5S	5487	Major		Inter Info	[10]
D0565		Empagliflozin	C23H27ClO7	11949646	Moderate		Inter Info	[7], [12], [19]
D1148		Nitrous acid	HNO2	24529	Moderate		Inter Info	[33], [34], [35]
D1211		Ozanimod	C23H24N4O3	52938427	Moderate		Inter Info	[36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48]
D1457		Selexipag	C26H32N4O4S	9913767	Moderate		Inter Info	[12], [51], [52]
D0055		Amifostine	C5H15N2O3PS	2141	Moderate		Inter Info	[54], [46], [55]
D0097		Apomorphine	C17H17NO2	6005	Moderate		Inter Info	[54], [56], [57]
D0128		Avanafil	C23H26ClN7O3	9869929	Moderate		Inter Info	[60], [61], [62]
D0245		Canagliflozin	C24H25FO5S	24812758	Moderate		Inter Info	[7], [12], [19]
D0418		Dapagliflozin	C21H25ClO6	9887712	Moderate		Inter Info	[7], [12], [19]
D0586		Epoprostenol	C20H32O5	5282411	Moderate		Inter Info	[12], [51], [52]
D0745		Guanfacine	C9H9Cl2N3O	3519	Moderate		Inter Info	[7], [12], [68]
D0792		Iloprost	C22H32O4	5311181	Moderate		Inter Info	[12], [51], [52]
D0853		Isocarboxazid	C12H13N3O2	3759	Moderate		Inter Info	[36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48]
D0933		Linezolid	C16H20FN3O4	441401	Moderate		Inter Info	[36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48]
D0980		Maraviroc	C29H41F2N5O	3002977	Moderate		Inter Info	[69]
D1251		Pentoxifylline	C13H18N4O3	4740	Moderate		Inter Info	[72]
D1263		Phenelzine	C8H12N2	3675	Moderate		Inter Info	[36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48]
D1345		Procarbazine	C12H19N3O	4915	Moderate		Inter Info	[36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48]
D1385		Rasagiline	C12H13N	3052776	Moderate		Inter Info	[36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48]
D1408		Riociguat	C20H19FN8O2	11304743	Moderate		Inter Info	[75]
D1437		Safinamide	C17H19FN2O2	131682	Moderate		Inter Info	[36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48]
D1455		Selegiline	C13H17N	26757	Moderate		Inter Info	[36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48]
D1465		Sildenafil	C22H30N6O4S	135398744	Moderate		Inter Info	[60], [61], [62]
D1620		Tranylcypromine	C9H11N	19493	Moderate		Inter Info	[36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48]
D1625		Treprostinil	C23H34O5	6918140	Moderate		Inter Info	[12], [51], [52]
D1682		Vardenafil	C23H32N6O4S	135400189	Moderate		Inter Info	[60], [61], [62]
D0711		Garlic	NA	NA	Minor		Inter Info	[76], [77]
D1527		Tadalafil	C22H19N3O4	110635	Minor		Inter Info	[79], [80]
	Increased risk of angioedema/anaphylactoid reactions					Drug Num: 4
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0629		Everolimus	C53H83NO14	6442177	Moderate		Inter Info	[65], [66], [67]
D1335		Pregabalin	C8H17NO2	5486971	Moderate		Inter Info	[12], [73], [74]
D1476		Sirolimus	C51H79NO13	5284616	Moderate		Inter Info	[65], [66], [67]
D1549		Temsirolimus	C56H87NO16	6918289	Moderate		Inter Info	[65], [66], [67]
	Increased risk of hyperkalemia					Drug Num: 33
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0138		Azilsartan medoxomil	C30H24N4O8	135409642	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0156		Benazepril	C24H28N2O5	5362124	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0254		Captopril	C9H15NO3S	44093	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0567		Enalapril	C20H28N2O5	5388962	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0587		Eprosartan	C23H24N2O4S	5281037	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0695		Fosinopril	C30H46NO7P	55891	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0844		Irbesartan	C25H28N6O	3749	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0938		Lisinopril	C21H31N3O5	5362119	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0954		Losartan	C22H23ClN6O	3961	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D1082		Moexipril	C27H34N2O7	91270	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D1170		Olmesartan	C24H26N6O3	158781	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D1256		Perindopril	C19H32N2O5	107807	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D1369		Quinapril	C25H30N2O5	54892	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D1379		Ramipril	C23H32N2O5	5362129	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D1545		Telmisartan	C33H30N4O2	65999	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D1618		Trandolapril	C24H34N2O5	5484727	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D1679		Valsartan	C24H29N5O3	60846	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D1086		Monopotassium phosphate	H2KO4P	516951	Moderate		Inter Info	[31], [32], [2]
D1316		Potassium acetate	C2H3KO2	517044	Moderate		Inter Info	[2]
D1317		Potassium bicarbonate	CHKO3	516893	Moderate		Inter Info	[2]
D1319		Potassium citrate	C6H5K3O7	13344	Moderate		Inter Info	[2]
D1320		Potassium gluconate	C6H11KO7	16760467	Moderate		Inter Info	[2]
D0058		Amiloride	C6H8ClN7O	16231	Moderate		Inter Info	[2]
D0102		Ardeparin	C26H42N2O37S5	772	Moderate		Inter Info	[58], [59]
D0414		Dalteparin	C26H42N2O37S5	772	Moderate		Inter Info	[58], [59]
D0415		Danaparoid	NA	NA	Moderate		Inter Info	[58], [59]
D0574		Enoxaparin	C26H42N2O37S5	772	Moderate		Inter Info	[58], [59]
D0753		Heparin	C26H42N2O37S5	772	Moderate		Inter Info	[58], [59]
D1318		Potassium chloride	ClK	4873	Moderate		Inter Info	[2]
D1321		Potassium Iodide	IK	4875	Moderate		Inter Info	[2]
D1501		Spironolactone	C24H32O4S	5833	Moderate		Inter Info	[2]
D1588		Tinzaparin	C26H42N2O37S5	772	Moderate		Inter Info	[58], [59]
D1631		Triamterene	C12H11N7	5546	Moderate		Inter Info	[2]
Pharmacodynamic antagonistic effects
	Antagonize the effect of antihypertensive agents					Drug Num: 39
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0017		Acetylsalicylic acid	C9H8O4	2244	Moderate		Inter Info	[12], [13], [14]
D0331		Choline salicylate	C12H19NO4	54686350	Moderate		Inter Info	[12], [13], [14]
D0436		Deflazacort	C25H31NO6	189821	Moderate		Inter Info	[12], [17]
D0926		Licorice	C42H62O16Zn	163463	Moderate		Inter Info	[27], [28], [29]
D1272		Phenyl salicylate	C13H10O3	8361	Moderate		Inter Info	[12], [13], [14]
D0210		Bromfenac	C15H12BrNO3	60726	Moderate		Inter Info	[12], [13], [14]
D0215		Budesonide	C25H34O6	5281004	Moderate		Inter Info	[12], [17]
D0298		Celecoxib	C17H14F3N3O2S	2662	Moderate		Inter Info	[12], [13], [14]
D0392		Corticotropin	C207H308N56O58S	16132265	Moderate		Inter Info	[12], [17]
D0453		Dexamethasone	C22H29FO5	5743	Moderate		Inter Info	[12], [17]
D0476		Diclofenac	C14H11Cl2NO2	3033	Moderate		Inter Info	[12], [13], [14]
D0624		Etodolac	C17H21NO3	3308	Moderate		Inter Info	[12], [13], [14]
D0645		Fenoprofen	C15H14O3	3342	Moderate		Inter Info	[12], [13], [14]
D0671		Fludrocortisone	C21H29FO5	31378	Moderate		Inter Info	[12], [17]
D0680		Flurbiprofen	C15H13FO2	3394	Moderate		Inter Info	[12], [13], [14]
D0773		Hydrocortisone	C21H30O5	5754	Moderate		Inter Info	[12], [17]
D0786		Ibuprofen	C13H18O2	3672	Moderate		Inter Info	[12], [13], [14]
D0800		Indomethacin	C19H16ClNO4	3715	Moderate		Inter Info	[12], [13], [14]
D0881		Ketoprofen	C16H14O3	3825	Moderate		Inter Info	[12], [13], [14]
D0882		Ketorolac	C15H13NO3	3826	Moderate		Inter Info	[12], [13], [14]
D0988		Meclofenamic acid	C14H11Cl2NO2	4037	Moderate		Inter Info	[12], [13], [14]
D0991		Mefenamic acid	C15H15NO2	4044	Moderate		Inter Info	[12], [13], [14]
D0995		Meloxicam	C14H13N3O4S2	54677470	Moderate		Inter Info	[12], [13], [14]
D1041		Methylprednisolone	C22H30O5	6741	Moderate		Inter Info	[12], [17]
D1097		Nabumetone	C15H16O2	4409	Moderate		Inter Info	[12], [13], [14]
D1109		Naproxen	C14H14O3	156391	Moderate		Inter Info	[12], [13], [14]
D1196		Oxaprozin	C18H15NO3	4614	Moderate		Inter Info	[12], [13], [14]
D1274		Phenylbutazone	C19H20N2O2	4781	Moderate		Inter Info	[12], [13], [14]
D1300		Piroxicam	C15H13N3O4S	54676228	Moderate		Inter Info	[12], [13], [14]
D1332		Prednisolone	C21H28O5	5755	Moderate		Inter Info	[12], [17]
D1334		Prednisone	C21H26O5	5865	Moderate		Inter Info	[12], [17]
D1421		Rofecoxib	C17H14O4S	5090	Moderate		Inter Info	[12], [13], [14]
D1439		Salicylic acid (sodium)	C7H6O3	338	Moderate		Inter Info	[12], [13], [14]
D1442		Salsalate	C14H10O5	5161	Moderate		Inter Info	[12], [13], [14]
D1520		Sulindac	C20H17FO3S	1548887	Moderate		Inter Info	[12], [13], [14]
D1563		Tetracosactide	C136H210N40O31S	16133802	Moderate		Inter Info	[12], [17]
D1606		Tolmetin	C15H15NO3	5509	Moderate		Inter Info	[12], [13], [14]
D1628		Triamcinolone	C21H27FO6	31307	Moderate		Inter Info	[12], [17]
D1674		Valdecoxib	C16H14N2O3S	119607	Moderate		Inter Info	[12], [13], [14]

References
1	Health Canada "Potential risks of cardiovascular and renal adverse events in patients with type 2 diabetes treated with aliskiren (RASILEZ) or aliskiren/hydrochlorothiazide (RASILEZ HCT)." .
2	Product Information. Tekturna (aliskiren). Novartis Pharmaceuticals, East Hanover, NJ.
3	EMA. European Medicines Agency "PRAC recommends against combined use of medicines affecting the renin-angiotensin (RAS) system: recommendation will now be considered by CHMP for final opinion." .
4	MHRA. Medicines and Healthcare Regulatory Agency "Combination use of medicines from different classes of renin-angiotensin system blocking agents: risk of hyperkalaemia, hypotension, and impaired renal function--new warnings.".
5	National Kidney Foundation "KDOQI Clinical Practice Guideline for Diabetes and CKD: 2012 update." Am J Kidney Dis 60 (2012): 850-86. [PMID: 23067652]
6	Novartis International AG "Novartis announces termination of ALTITUDE study with Rasilez Tekturna in high-risk patients with diabetes and renal impairment.".
7	Cerner Multum, Inc. "Australian Product Information.".
8	Product Information. Sporanox (itraconazole). Janssen Pharmaceutica, Titusville, NJ.
9	Tapaninen T, Backman JT, Kurkinen K, Neuvonen P, Niemi M "Itraconazole, a P-glycoprotein and CYP3A4 inhibitor, markedly raises the plasma concentrations and enhances the renin-inhibiting effect of aliskiren." J Clin Pharmacol 51 (2011): 359-67. [PMID: 20400651]
10	Product Information. Zanaflex (tizanidine). Acorda Therapeutics, Hawthorne, NY.
11	Canadian Pharmacists Association.
12	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
13	EMEA. European Medicines Agency "EPARs. European Union Public Assessment Reports.".
14	Agencia Espaola de Medicamentos y Productos Sanitarios Healthcare "Centro de informacion online de medicamentos de la AEMPS - CIMA."
15	Product Information. Xeglyze (abametapir topical). Dr. Reddy's Laboratories Inc, Upper Saddle River, NJ.
16	Product Information. Erleada (apalutamide). Janssen Biotech, Inc., Horsham, PA, PA.
17	Multum Information Services, Inc. Expert Review Panel.
18	Gorski JC, Huang SM, Pinto A, et al. "The effect of echinacea (Echinacea purpurea root) on cytochrome P450 activity in vivo." Clin Pharmacol Ther 75 (2004): 89-100. [PMID: 14749695]
19	Product Information. Jardiance (empagliflozin). Boehringer Ingelheim, Ridgefield, CT.
20	Product Information. Braftovi (encorafenib). Array BioPharma Inc., Boulder, CO.
21	Product Information. Balversa (erdafitinib). Janssen Products, LP, Horsham, PA.
22	Product Information. Tavalisse (fostamatinib). Rigel Pharmaceuticals, South San Francisco, CA.
23	Product Information. Imbruvica (ibrutinib). Pharmacyclics Inc, Sunnyvale, CA.
24	Product Information. Vitrakvi (larotrectinib). Bayer Pharmaceutical Inc, West Haven, CT.
25	Product Information. Reyvow (lasmiditan). Lilly, Eli and Company, Indianapolis, IN.
26	Product Information. Xenleta (lefamulin). Nabriva Therapeutics US, Inc., King of Prussia, PA.
27	Stewart PM, Wallace AM, Valentino R, Burt D, Shackleton CH, Edwards CR "Mineralocorticoid activity of liquorice: 11-beta-hydroxysteroid dehydrogenase deficiency comes of age." Lancet 2 (1987): 821-4. [PMID: 2889032]
28	Cumming AM "Metabolic effects of licorice." Br Med J 1 (1977): 906
29	Epstein MT, Espiner EA, Donald RA, Hughes H "Effect of eating liquorice on the renin-angiotensin aldosterone axis in normal subjects." Br Med J 1 (1977): 488-90
30	Product Information. Lorbrena (lorlatinib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
31	Tapaninen T, Neuvonen PJ, Niemi M "Grapefruit juice greatly reduces the plasma concentrations of the OATP2B1 and CYP3A4 substrate aliskiren." Clin Pharmacol Ther 88 (2010): 339-42. [PMID: 20664534]
32	Vaidyanathan S, Jarugula V, Dieterich HA, Howard D, Dole WP "Clinical pharmacokinetics and pharmacodynamics of aliskiren." Clin Pharmacokinet 47 (2008): 515-31. [PMID: 18611061]
33	Fuhr U, Maier-Bruggemann A, Blume H, et al. "Grapefruit juice increases oral nimodipine bioavailability." Int J Clin Pharmacol Ther 36 (1998): 126-32. [PMID: 9562227]
34	Gunston GD, Mehta U "Potentially serious drug interactions with grapefruit juice." S Afr Med J 90 (2000): 41. [PMID: 10721388]
35	Product Information. Sodium Nitrite (sodium nitrite). Hope Pharmaceuticals, Scottsdale, AZ.
36	Ban TA "Drug interactions with psychoactive drugs." Dis Nerv Syst 36 (1975): 164-6. [PMID: 1116424]
37	De Vita VT, Hahn MA, Oliverio VT "Monoamine oxidase inhibition by a new carcinostatic agent, n-isopropyl-a-(2-methylhydrazino)-p-toluamide (MIH). (30590)." Proc Soc Exp Biol Med 120 (1965): 561-5. [PMID: 4379192]
38	Goldberg LI "Monoamine oxidase inhibitors: adverse reactions and possible mechanisms." JAMA 190 (1964): 456-62. [PMID: 14197995]
39	Golwyn DH, Sevlie CP "Monoamine oxidase inhibitor hypertensive crisis headache and orthostatic hypotension." J Clin Psychopharmacol 13 (1993): 77-8. [PMID: 8486823]
40	Kronig MH, Roose SP, Walsh BT, Woodring S, Glassman AH "Blood pressure effects of phenelzine." J Clin Psychopharmacol 3 (1983): 307-10. [PMID: 6630590]
41	Pettinger WA, Soyangco FG, Oates JA "Inhibition of monoamine oxidase in man by furazolidone." Clin Pharmacol Ther 9 (1968): 442-7. [PMID: 5655478]
42	Product Information. Marplan (isocarboxazid) Roche Laboratories, Nutley, NJ.
43	Product Information. Matulane (procarbazine). Roche Laboratories, Nutley, NJ.
44	Product Information. Nardil (phenelzine). Parke-Dvis, Morris Plains, NJ.
45	Product Information. Parnate (tranylcypromine). SmithKline Beecham, Philadelphia, PA.
46	Product Information. Xatral (alfuzosin). Sanofi-Synthelabo Canada Inc, Markham, ON.
47	Reggev A, Vollhardt BR "Bradycardia induced by an interaction between phenelzine and beta blockers." Psychosomatics 30 (1992): 106-8. [PMID: 2913594]
48	Schulz R, Antonin KH, Hoffmann E, et al "Tyramine kinetics and pressor sensitivity during monoamine oxidase inhibition by selegiline." Clin Pharmacol Ther 46 (1989): 528-36. [PMID: 2510962]
49	Product Information. Varubi (rolapitant). Tesaro Inc., Waltham, MA.
50	EMA. European Medicines Agency. European Union "EMA - List of medicines under additional monitoring.".
51	Product Information. Flolan (epoprostenol). Glaxo Wellcome, Research Triangle Park, NC.
52	Product Information. Remodulin (treprostinil). United Therapeutics Corp, Silver Spring, MD.
53	Product Information. Xermelo (telotristat ethyl). Lexicon Pharmaceuticals, Inc., The Woodlands, TX.
54	Bailey DG, Dresser GK "Natural products and adverse drug interactions." Can Med Assoc J 170 (2004): 1531-2. [PMID: 15136542]
55	Product Information. Ethyol (amifostine). Alza, Palo Alto, CA.
56	Ho PC, Ghose K, Saville D, Wanwimolruk S "Effect of grapefruit juice on pharmacokinetics and pharmacodynamics of verapamil enantiomers in healthy volunteers." Eur J Clin Pharmacol 56 (2000): 693-8. [PMID: 11214778]
57	Product Information. Apokyn (apomorphine). Mylan Pharmaceuticals Inc, Morgantown, WV.
58	Agencia Espaola de Medicamentos y Productos Sanitarios Healthcare "Centro de informacion online de medicamentos de la AEMPS - CIMA.".
59	EMEA. European Medicines Agency "EPARs. European Union Public Assessment Reports.".
60	Product Information. Levitra (vardenafil). Bayer, West Haven, CT.
61	Product Information. Stendra (avanafil). Vivus Inc, Mountain View, CA.
62	Product Information. Viagra (sildenafil). Pfizer US Pharmaceuticals, New York, NY.
63	Benoist G, van Oort I, et al "Drug-drug interaction potential in men treated with enzalutamide: Mind the gap." Br J Clin Pharmacol 0 (2017): epub. [PMID: 28881501]
64	Product Information. Xtandi (enzalutamide). Astellas Pharma US, Inc, Deerfield, IL.
65	Product Information. Afinitor (everolimus). Novartis Pharmaceuticals, East Hanover, NJ.
66	Product Information. Rapamune (sirolimus) Wyeth-Ayerst Laboratories, Philadelphia, PA.
67	Product Information. Torisel (temsirolimus). Wyeth-Ayerst Laboratories, Philadelphia, PA.
68	Product Information. Tenex (guanfacine). Wyeth-Ayerst Laboratories, Philadelphia, PA.
69	Product Information. Selzentry (maraviroc). Pfizer U.S. Pharmaceuticals Group, New York, NY.
70	He K, Woolf TF, Hollenberg PF "Mechanism-based inactivation of cytochrome P-450-3A4 by mifepristone (RU486)." J Pharmacol Exp Ther 288 (1999): 791-7. [PMID: 9918590]
71	Product Information. Mifeprex (mifepristone) Danco Laboratories, New York, NY.
72	Product Information. Trental (pentoxifylline). Hoechst Marion-Roussel Inc, Kansas City, MO.
73	Product Information. Lyrica (pregabalin). Pfizer U.S. Pharmaceuticals Group, New York, NY.
74	Ray K, Dorman S, Watson R "Severe hyperkalaemia due to the concomitant use of salt substitutes and ACE inhibitors in hypertension: a potentially life threatening interaction." J Hum Hypertens 13 (1999): 717-20. [PMID: 10516744]
75	Product Information. Adempas (riociguat). Bayer Pharmaceutical Inc, West Haven, CT.
76	Tattelman E "Health effects of garlic." Am Fam Physician 72 (2005): 103-6
77	Richard CL, Jurgens TM "Effects of natural health products on blood pressure." Ann Pharmacother 39 (2005): 712-20
78	Patel S, Robinson R, Burk M "Hypertensive crisis associated with St. John's Wort." Am J Med 112 (2002): 507-8. [PMID: 11959071]
79	Product Information. Cialis (tadalafil). Lilly, Eli and Company, Indianapolis, IN.
80	Product Information. Rapaflo (silodosin). Watson Pharmaceuticals, Corona, CA.

Details of Drug

Details of Drug

Cite MecDDI

About MecDDI

Correspondence