Drug General Information (ID: DDIC9HO8Q0)
Drug Name			Triamterene		Drug Info		Aliskiren		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Diuretics				Antihypertensive Agents
Structure

Mechanism of Triamterene-Aliskiren Interaction (Severity Level: Moderate)
Increased risk of hyperkalemia Click to Show/Hide Mechanism Graph
Drug Name		Triamterene				Aliskiren
Mechanism		Hyperkalemia				Hyperkalemia
Key Mechanism Factor 1
		Factor Name		Hyperkalemia
		Factor Description		Hyperkalemia is a condition in which the level of potassium in the blood is higher than normal. While mild cases may not produce symptoms, severe hyperkalemia can lead to fatal arrhythmias if left untreated.
Mechanism Description		Increased risk of hyperkalemia by the combination of Triamterene and Aliskiren

Recommended Action
Management		Caution is advised if aliskiren is used in combination with potassium-sparing diuretics or potassium salts. Routine monitoring of electrolytes and renal function may be indicated, particularly in patients with renal impairment, diabetes, old age, worsening heart failure, or a risk for dehydration. Patients should be advised to seek medical attention if they experience signs and symptoms of hyperkalemia such as weakness, listlessness, confusion, tingling of the extremities, and irregular heartbeat.

References
1	Product Information. Tekturna (aliskiren). Novartis Pharmaceuticals, East Hanover, NJ.