Drug General Information (ID: DDI8ZQGYPF)
Drug Name			Trandolapril		Drug Info		Heparin		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antihypertensive Agents				Anticoagulants
Structure

Mechanism of Trandolapril-Heparin Interaction (Severity Level: Moderate)
Increased risk of hyperkalemia Click to Show/Hide Mechanism Graph
Drug Name		Trandolapril				Heparin
Mechanism		Hyperkalemia				Hyperkalemia
Key Mechanism Factor 1
		Factor Name		Hyperkalemia
		Factor Description		Hyperkalemia is a condition in which the level of potassium in the blood is higher than normal. While mild cases may not produce symptoms, severe hyperkalemia can lead to fatal arrhythmias if left untreated.
Mechanism Description		Increased risk of hyperkalemia by the combination of Trandolapril and Heparin

Recommended Action
Management		Caution is advised if ACE inhibitors or ARBs are used with heparin or low molecular weight heparin. Serum potassium and renal function should be checked regularly.

References
1	Product Information. Micardis (telmisartan). Boehringer-Ingelheim, Ridgefield, CT.
2	Product Information. Diovan (valsartan). Novartis Pharmaceuticals, East Hanover, NJ.
3	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
4	Product Information. Cozaar (losartan). Merck & Co, Inc, West Point, PA.
5	Product Information. Benicar (olmesartan). Sankyo Parke Davis, Parsippany, NJ.
6	Product Information. Atacand (candesartan). Astra Pharmaceuticals, Wayne, PA.
7	Product Information. Edarbi (azilsartan). Takeda Pharmaceuticals America, Lincolnshire, IL.
8	Product Information. Teveten (eprosartan). SmithKline Beecham, Philadelphia, PA.
9	Perazella MA "Drug-induced hyperkalemia: old culprits and new offenders." Am J Med 109 (2000): 307-14. [PMID: 10996582]
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