Details of Drug

Drug General Information (ID: D1618)
Drug Name	Trandolapril
Drug Type	Small molecule
Drug Synonymous	Gopten; Mavik; Odric; Odrik; Preran; Trandolaprilum; Udrik; Trandolaprilum [Latin]; RU 44570; RU44570; Mavik (TN); RU-44570; Trandolapril [INN:BAN]; Trandolapril (JAN/INN); (2S,3aR,7aS)-1-((S)-N-((S)-1-Carboxy-3-phenylpropyl)alanyl)hexahydro-2-indolinecarboxylic acid, 1-ethyl ester; (2S,3aR,7aS)-1-(N-((1S)-1-((Ethyloxy)carbonyl)-3-phenylpropyl)-L-alanyl)octahydro-1H-indole-2-carboxylic Acid; (2S,3aR,7aS)-1-[(2S)-2-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]propanoyl]-2,3,3a,4,5,6,7,7a-octahydroindole-2-carboxylicacid; 1-(2-((1-(ethoxycarbonyl)-3-phenylpropyl)amino)-1-oxopropyl)octahydro-1H-indol-2-carboxylic acid Click to Show/Hide
Disease Class	BA00-BA04: Hypertension
Therapeutic Class	Antihypertensive Agents
Structure
Structure	3D Structure		2D Structure
Formula	C24H34N2O5
InChI	1S/C24H34N2O5/c1-3-31-24(30)19(14-13-17-9-5-4-6-10-17)25-16(2)22(27)26-20-12-8-7-11-18(20)15-21(26)23(28)29/h4-6,9-10,16,18-21,25H,3,7-8,11-15H2,1-2H3,(H,28,29)/t16-,18+,19-,20-,21-/m0/s1
InChIKey	VXFJYXUZANRPDJ-WTNASJBWSA-N
Canonical SMILES	CCOC(=O)C(CCC1=CC=CC=C1)NC(C)C(=O)N2C3CCCCC3CC2C(=O)O
External Link
	Pubchem ID	5484727
	CAS Number	87679-37-6
	CHEBI ID	9649
	TTD ID	D0M5OC
	INTEDE ID	DR2657
	VARIDT ID	DR00240

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM001 Affected gastrointestinal absorption AM005 Affected excretion pathways AM006 Pharmacodynamic additive effects AM007 Pharmacodynamic antagonistic effects BM003 Complex formation BM005 Altered gastric pH BM028 Competitive inhibition of renal tubular secretion BM032 Decreased renal excretion (Unspecific) BM038 Additive CNS depression effects BM042 Additive hypotensive effects BM044 Additive myelosuppressive effects BM048 Increased risk of angioedema/anaphylactoid reactions BM055 Increased risk of hepatotoxicity BM058 Increased risk of hyperkalemia BM064 Increased risk of hypoglycemia BM072 Increased risk of nephrotoxicity BM089 Antagonize the effect of antihypertensive agents BM107 Attenuated pharmacological effects (Unspecific) BM109 Increased risk of other adverse reactions (Unspecific)
Relation Graph

Full list of drugs interacting with Trandolapril
Affected gastrointestinal absorption
	Complex formation					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0893		Lanthanum carbonate	C3La2O9	168924	Moderate		Inter Info	[67], [220], [12], [334], [335], [336]
	Altered gastric pH					Drug Num: 9
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0049		Aluminum hydroxide	AlH3O3	10176082	Minor		Inter Info	[365]
D0236		Calcium carbonate	CCaO3	10112	Minor		Inter Info	[365]
D0483		Didanosine	C10H12N4O3	135398739	Minor		Inter Info	[365]
D0967		Magaldrate	AlHMgO5S+2	3086011	Minor		Inter Info	[365]
D0968		Magnesium carbonate	CMgO3	11029	Minor		Inter Info	[365]
D0973		Magnesium hydroxide	H2MgO2	14791	Minor		Inter Info	[365]
D0974		Magnesium oxide	MgO	14792	Minor		Inter Info	[365]
D1480		Sodium bicarbonate	CHNaO3	516892	Minor		Inter Info	[365]
D1483		Sodium citrate	C6H5Na3O7	6224	Minor		Inter Info	[365]
Affected excretion pathways
	Competitive inhibition of renal tubular secretion					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0491		Digoxin	C41H64O14	2724385	Moderate		Inter Info	[272], [273], [274]
D1341		Probenecid	C13H19NO4S	4911	Minor		Inter Info	[82], [370], [371]
	Decreased renal excretion (Unspecific)					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0940		Lithium carbonate	CLi2O3	11125	Major		Inter Info	[70], [71], [72]
Pharmacodynamic additive effects
	Additive CNS depression effects					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1172		Olopatadine (nasal)	C21H23NO3	5281071	Moderate		Inter Info	[346], [344], [351]
	Additive hypotensive effects					Drug Num: 154
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1596		Tizanidine	C9H8ClN5S	5487	Major		Inter Info	[83]
D0030		Aldesleukin	NA	NA	Moderate		Inter Info	[214]
D0036		Alfuzosin	C19H27N5O4	2092	Moderate		Inter Info	[215], [216]
D0045		Alprazolam	C17H13ClN4	2118	Moderate		Inter Info	[217], [218], [219]
D0068		Amitriptyline	C20H23N	2160	Moderate		Inter Info	[217], [218], [219]
D0143		Baclofen	C10H12ClNO2	2284	Moderate		Inter Info	[217], [218], [219]
D0158		Bendroflumethiazide	C15H14F3N3O4S2	2315	Moderate		Inter Info	[24], [220], [233], [234], [235], [236], [237], [238], [239], [240], [241], [242], [55], [243], [244], [245], [246], [247], [42], [248], [249], [250], [251]
D0205		Brimonidine (ophthalmic)	C11H10BrN5	2435	Moderate		Inter Info	[253], [254], [255]
D0206		Brimonidine (topical)	C11H10BrN5	2435	Moderate		Inter Info	[253], [254], [255]
D0222		Buspirone	C21H31N5O2	2477	Moderate		Inter Info	[217], [218], [219]
D0224		Butabarbital	C10H16N2O3	2479	Moderate		Inter Info	[217], [218], [219]
D0228		Cabergoline	C26H37N5O2	54746	Moderate		Inter Info	[217], [218], [219]
D0263		Carisoprodol	C12H24N2O4	2576	Moderate		Inter Info	[217], [218], [219]
D0324		Chlorpromazine	C17H19ClN2S	2726	Moderate		Inter Info	[259], [260], [261], [262], [263], [264], [265], [266], [267], [268], [269]
D0326		Chlorthalidone	C14H11ClN2O4S	2732	Moderate		Inter Info	[24], [220], [233], [234], [235], [236], [237], [238], [239], [240], [241], [242], [55], [243], [244], [245], [246], [247], [42], [248], [249], [250], [251]
D0356		Clobazam	C16H13ClN2O2	2789	Moderate		Inter Info	[217], [218], [219]
D0370		Clozapine	C18H19ClN4	135398737	Moderate		Inter Info	[259], [260], [261], [262], [263], [264], [265], [266], [267], [268], [269]
D0379		Codeine	C18H21NO3	5284371	Moderate		Inter Info	[217], [218], [219]
D0533		Dronabinol	C21H30O2	16078	Moderate		Inter Info	[217], [218], [219]
D0795		Imipramine	C19H24N2	3696	Moderate		Inter Info	[217], [218], [219]
D0951		Lorazepam	C15H10Cl2N2O2	3958	Moderate		Inter Info	[217], [218], [219]
D1001		Meperidine	C15H21NO2	4058	Moderate		Inter Info	[217], [218], [219]
D1005		Meprobamate	C9H18N2O4	4064	Moderate		Inter Info	[217], [218], [219]
D1017		Methadone	C21H27NO	4095	Moderate		Inter Info	[217], [218], [219]
D1023		Methocarbamol	C11H15NO5	4107	Moderate		Inter Info	[217], [218], [219]
D1075		Mirtazapine	C17H19N3	4205	Moderate		Inter Info	[217], [218], [219]
D1089		Morphine	C17H19NO3	5288826	Moderate		Inter Info	[217], [218], [219]
D1096		Nabilone	C24H36O3	5284592	Moderate		Inter Info	[217], [218], [219]
D1166		Olanzapine	C17H20N4S	135398745	Moderate		Inter Info	[259], [260], [261], [262], [263], [264], [265], [266], [267], [268], [269]
D1203		Oxycodone	C18H21NO4	5284603	Moderate		Inter Info	[217], [218], [219]
D1331		Prazosin	C19H21N5O4	4893	Moderate		Inter Info	[215], [216]
D1346		Prochlorperazine	C20H24ClN3S	4917	Moderate		Inter Info	[259], [260], [261], [262], [263], [264], [265], [266], [267], [268], [269]
D1351		Promazine	C17H20N2S	4926	Moderate		Inter Info	[259], [260], [261], [262], [263], [264], [265], [266], [267], [268], [269]
D1453		Secobarbital	C12H18N2O3	5193	Moderate		Inter Info	[217], [218], [219]
D1465		Sildenafil	C22H30N6O4S	135398744	Moderate		Inter Info	[290], [291], [292]
D1547		Temazepam	C16H13ClN2O2	5391	Moderate		Inter Info	[217], [218], [219]
D1572		Thiethylperazine	C22H29N3S2	5440	Moderate		Inter Info	[259], [260], [261], [262], [263], [264], [265], [266], [267], [268], [269]
D1611		Torasemide	C16H20N4O3S	41781	Moderate		Inter Info	[55], [245], [249]
D0012		Acetazolamide	C4H6N4O3S2	1986	Moderate		Inter Info	[24], [220], [233], [234], [235], [236], [237], [238], [239], [240], [241], [242], [55], [243], [244], [245], [246], [247], [42], [248], [249], [250], [251]
D0037		Alimemazine	C18H22N2S	5574	Moderate		Inter Info	[263], [265], [267]
D0055		Amifostine	C5H15N2O3PS	2141	Moderate		Inter Info	[295], [216], [296]
D0067		Amisulpride	C17H27N3O4S	2159	Moderate		Inter Info	[259], [260], [261], [262], [263], [264], [265], [266], [267], [268], [269]
D0072		Amoxapine	C17H16ClN3O	2170	Moderate		Inter Info	[217], [218], [219]
D0097		Apomorphine	C17H17NO2	6005	Moderate		Inter Info	[295], [297], [298]
D0098		Apraclonidine	C9H10Cl2N4	2216	Moderate		Inter Info	[253], [254], [255]
D0105		Aripiprazole	C23H27Cl2N3O2	60795	Moderate		Inter Info	[259], [260], [261], [262], [263], [264], [265], [266], [267], [268], [269]
D0112		Asenapine	C17H16ClNO	3036780	Moderate		Inter Info	[259], [260], [261], [262], [263], [264], [265], [266], [267], [268], [269]
D0128		Avanafil	C23H26ClN7O3	9869929	Moderate		Inter Info	[290], [291], [292]
D0161		Benzhydrocodone	C25H25NO4	49836084	Moderate		Inter Info	[217], [218], [219]
D0166		Benzthiazide	C15H14ClN3O4S3	2343	Moderate		Inter Info	[24], [220], [233], [234], [235], [236], [237], [238], [239], [240], [241], [242], [55], [243], [244], [245], [246], [247], [42], [248], [249], [250], [251]
D0202		Brexpiprazole	C25H27N3O2S	11978813	Moderate		Inter Info	[259], [260], [261], [262], [263], [264], [265], [266], [267], [268], [269]
D0213		Bromotheophylline	C7H7BrN4O2	11808	Moderate		Inter Info	[55], [245], [249]
D0217		Bumetanide	C17H20N2O5S	2471	Moderate		Inter Info	[24], [220], [233], [234], [235], [236], [237], [238], [239], [240], [241], [242], [55], [243], [244], [245], [246], [247], [42], [248], [249], [250], [251]
D0219		Buprenorphine	C29H41NO4	644073	Moderate		Inter Info	[217], [218], [219]
D0220		Bupropion	C13H18ClNO	444	Moderate		Inter Info	[217], [218], [219]
D0226		Butorphanol	C21H29NO2	5361092	Moderate		Inter Info	[217], [218], [219]
D0245		Canagliflozin	C24H25FO5S	24812758	Moderate		Inter Info	[220], [12], [301]
D0262		Cariprazine	C21H32Cl2N4O	11154555	Moderate		Inter Info	[259], [260], [261], [262], [263], [264], [265], [266], [267], [268], [269]
D0311		Chloral hydrate	C2H3Cl3O2	2707	Moderate		Inter Info	[217], [218], [219]
D0321		Chlorothiazide	C7H6ClN3O4S2	2720	Moderate		Inter Info	[24], [220], [233], [234], [235], [236], [237], [238], [239], [240], [241], [242], [55], [243], [244], [245], [246], [247], [42], [248], [249], [250], [251]
D0362		Clonazepam	C15H10ClN3O3	2802	Moderate		Inter Info	[217], [218], [219]
D0365		Clorazepic acid	C16H11ClN2O3	2809	Moderate		Inter Info	[217], [218], [219]
D0418		Dapagliflozin	C21H25ClO6	9887712	Moderate		Inter Info	[220], [12], [301]
D0459		Dexmedetomidine	C13H16N2	5311068	Moderate		Inter Info	[220], [307], [308]
D0467		Dextropropoxyphene	C22H29NO2	10100	Moderate		Inter Info	[217], [218], [219]
D0479		Diclofenamide	C6H6Cl2N2O4S2	3038	Moderate		Inter Info	[55], [245], [249]
D0493		Dihydrocodeine	C18H23NO3	5284543	Moderate		Inter Info	[217], [218], [219]
D0498		Dimenhydrinate	C24H28ClN5O3	10660	Moderate		Inter Info	[217], [218], [219]
D0502		Diphenhydramine	C17H21NO	3100	Moderate		Inter Info	[217], [218], [219]
D0524		Doxazosin	C23H25N5O5	3157	Moderate		Inter Info	[215], [216]
D0525		Doxepin	C19H21NO	667477	Moderate		Inter Info	[217], [218], [219]
D0526		Doxepin (topical)	C19H21NO	667477	Moderate		Inter Info	[217], [218], [219]
D0565		Empagliflozin	C23H27ClO7	11949646	Moderate		Inter Info	[220], [12], [301]
D0586		Epoprostenol	C20H32O5	5282411	Moderate		Inter Info	[12], [313], [314]
D0613		Etacrynic acid	C13H12Cl2O4	3278	Moderate		Inter Info	[55], [245], [249]
D0678		Fluphenazine	C22H26F3N3OS	3372	Moderate		Inter Info	[259], [260], [261], [262], [263], [264], [265], [266], [267], [268], [269]
D0679		Flurazepam	C21H23ClFN3O	3393	Moderate		Inter Info	[217], [218], [219]
D0704		Furosemide	C12H11ClN2O5S	3440	Moderate		Inter Info	[24], [220], [233], [234], [235], [236], [237], [238], [239], [240], [241], [242], [55], [243], [244], [245], [246], [247], [42], [248], [249], [250], [251]
D0731		Glycerin	C3H8O3	753	Moderate		Inter Info	[24], [220], [233], [234], [235], [236], [237], [238], [239], [240], [241], [242], [55], [243], [244], [245], [246], [247], [42], [248], [249], [250], [251]
D0771		Hydrochlorothiazide	C7H8ClN3O4S2	3639	Moderate		Inter Info	[24], [220], [233], [234], [235], [236], [237], [238], [239], [240], [241], [242], [55], [243], [244], [245], [246], [247], [42], [248], [249], [250], [251]
D0772		Hydrocodone	C18H21NO3	5284569	Moderate		Inter Info	[217], [218], [219]
D0781		Hydroxyzine	C21H27ClN2O2	3658	Moderate		Inter Info	[217], [218], [219]
D0791		Iloperidone	C24H27FN2O4	71360	Moderate		Inter Info	[259], [260], [261], [262], [263], [264], [265], [266], [267], [268], [269]
D0792		Iloprost	C22H32O4	5311181	Moderate		Inter Info	[12], [313], [314]
D0798		Indapamide	C16H16ClN3O3S	3702	Moderate		Inter Info	[24], [220], [233], [234], [235], [236], [237], [238], [239], [240], [241], [242], [55], [243], [244], [245], [246], [247], [42], [248], [249], [250], [251]
D0853		Isocarboxazid	C12H13N3O2	3759	Moderate		Inter Info	[321], [322], [323], [324], [325], [326], [327], [328], [329], [330], [216], [331], [332]
D0861		Isosorbide dinitrate	C6H8N2O8	6883	Moderate		Inter Info	[333]
D0862		Isosorbide mononitrate	C6H9NO6	27661	Moderate		Inter Info	[333]
D0918		Levodopa	C9H11NO4	6047	Moderate		Inter Info	[295], [297], [337]
D0933		Linezolid	C16H20FN3O4	441401	Moderate		Inter Info	[321], [322], [323], [324], [325], [326], [327], [328], [329], [330], [216], [331], [332]
D0959		Lumateperone	C24H28FN3O	21302490	Moderate		Inter Info	[259], [260], [261], [262], [263], [264], [265], [266], [267], [268], [269]
D0978		Mannitol	C6H14O6	6251	Moderate		Inter Info	[24], [220], [233], [234], [235], [236], [237], [238], [239], [240], [241], [242], [55], [243], [244], [245], [246], [247], [42], [248], [249], [250], [251]
D0979		Maprotiline	C20H23N	4011	Moderate		Inter Info	[217], [218], [219]
D0980		Maraviroc	C29H41F2N5O	3002977	Moderate		Inter Info	[341]
D1010		Mesoridazine	C21H26N2OS2	4078	Moderate		Inter Info	[259], [260], [261], [262], [263], [264], [265], [266], [267], [268], [269]
D1018		Methazolamide	C5H8N4O3S2	4100	Moderate		Inter Info	[24], [220], [233], [234], [235], [236], [237], [238], [239], [240], [241], [242], [55], [243], [244], [245], [246], [247], [42], [248], [249], [250], [251]
D1026		Methotrimeprazine	C19H24N2OS	72287	Moderate		Inter Info	[259], [260], [261], [262], [263], [264], [265], [266], [267], [268], [269]
D1048		Metolazone	C16H16ClN3O3S	4170	Moderate		Inter Info	[24], [220], [233], [234], [235], [236], [237], [238], [239], [240], [241], [242], [55], [243], [244], [245], [246], [247], [42], [248], [249], [250], [251]
D1084		Molindone	C16H24N2O2	23897	Moderate		Inter Info	[259], [260], [261], [262], [263], [264], [265], [266], [267], [268], [269]
D1100		Nalbuphine	C21H27NO4	5311304	Moderate		Inter Info	[217], [218], [219]
D1117		Nefazodone	C25H32ClN5O2	4449	Moderate		Inter Info	[344], [345], [346]
D1125		Nesiritide	C143H244N50O42S4	53325981	Moderate		Inter Info	[82], [283], [347]
D1146		Nitroglycerin	C3H5N3O9	4510	Moderate		Inter Info	[333]
D1148		Nitrous acid	HNO2	24529	Moderate		Inter Info	[348], [349], [350]
D1158		Nortriptyline	C19H21N	4543	Moderate		Inter Info	[217], [218], [219]
D1169		Oliceridine	C22H30N2O2S	66553195	Moderate		Inter Info	[217], [218], [219]
D1188		Orphenadrine	C18H23NO	4601	Moderate		Inter Info	[217], [218], [219]
D1197		Oxazepam	C15H11ClN2O2	4616	Moderate		Inter Info	[217], [218], [219]
D1211		Ozanimod	C23H24N4O3	52938427	Moderate		Inter Info	[321], [322], [323], [324], [325], [326], [327], [328], [329], [330], [216], [331], [332]
D1215		Paliperidone	C23H27FN4O3	115237	Moderate		Inter Info	[259], [260], [261], [262], [263], [264], [265], [266], [267], [268], [269]
D1224		Paraldehyde	C6H12O3	31264	Moderate		Inter Info	[217], [218], [219]
D1247		Pentazocine	C19H27NO	441278	Moderate		Inter Info	[217], [218], [219]
D1251		Pentoxifylline	C13H18N4O3	4740	Moderate		Inter Info	[352]
D1263		Phenelzine	C8H12N2	3675	Moderate		Inter Info	[321], [322], [323], [324], [325], [326], [327], [328], [329], [330], [216], [331], [332]
D1267		Phenoxybenzamine	C18H22ClNO	4768	Moderate		Inter Info	[215], [216]
D1311		Polythiazide	C11H13ClF3N3O4S3	4870	Moderate		Inter Info	[24], [220], [233], [234], [235], [236], [237], [238], [239], [240], [241], [242], [55], [243], [244], [245], [246], [247], [42], [248], [249], [250], [251]
D1345		Procarbazine	C12H19N3O	4915	Moderate		Inter Info	[321], [322], [323], [324], [325], [326], [327], [328], [329], [330], [216], [331], [332]
D1352		Promethazine	C17H20N2S	4927	Moderate		Inter Info	[259], [260], [261], [262], [263], [264], [265], [266], [267], [268], [269]
D1355		Propiomazine	C20H24N2OS	4940	Moderate		Inter Info	[259], [260], [261], [262], [263], [264], [265], [266], [267], [268], [269]
D1368		Quetiapine	C21H25N3O2S	5002	Moderate		Inter Info	[259], [260], [261], [262], [263], [264], [265], [266], [267], [268], [269]
D1385		Rasagiline	C12H13N	3052776	Moderate		Inter Info	[321], [322], [323], [324], [325], [326], [327], [328], [329], [330], [216], [331], [332]
D1391		Remimazolam	C21H19BrN4O2	9867812	Moderate		Inter Info	[217], [218], [219]
D1408		Riociguat	C20H19FN8O2	11304743	Moderate		Inter Info	[358]
D1413		Risperidone	C23H27FN4O2	5073	Moderate		Inter Info	[259], [260], [261], [262], [263], [264], [265], [266], [267], [268], [269]
D1437		Safinamide	C17H19FN2O2	131682	Moderate		Inter Info	[321], [322], [323], [324], [325], [326], [327], [328], [329], [330], [216], [331], [332]
D1455		Selegiline	C13H17N	26757	Moderate		Inter Info	[321], [322], [323], [324], [325], [326], [327], [328], [329], [330], [216], [331], [332]
D1457		Selexipag	C26H32N4O4S	9913767	Moderate		Inter Info	[12], [313], [314]
D1466		Silodosin	C25H32F3N3O4	5312125	Moderate		Inter Info	[215], [216]
D1485		Sodium oxybate	C4H7NaO3	23663870	Moderate		Inter Info	[217], [218], [219]
D1552		Terazosin	C19H25N5O4	5401	Moderate		Inter Info	[215], [216]
D1560		Tetrabenazine	C19H27NO3	6018	Moderate		Inter Info	[217], [218], [219]
D1574		Thioridazine	C21H26N2S2	5452	Moderate		Inter Info	[259], [260], [261], [262], [263], [264], [265], [266], [267], [268], [269]
D1576		Thiothixene	C23H29N3O2S2	941651	Moderate		Inter Info	[259], [260], [261], [262], [263], [264], [265], [266], [267], [268], [269]
D1624		Trazodone	C19H22ClN5O	5533	Moderate		Inter Info	[217], [218], [219]
D1633		Trichlormethiazide	C8H8Cl3N3O4S2	5560	Moderate		Inter Info	[24], [220], [233], [234], [235], [236], [237], [238], [239], [240], [241], [242], [55], [243], [244], [245], [246], [247], [42], [248], [249], [250], [251]
D1637		Trifluoperazine	C21H24F3N3S	5566	Moderate		Inter Info	[259], [260], [261], [262], [263], [264], [265], [266], [267], [268], [269]
D1647		Trimipramine	C20H26N2	5584	Moderate		Inter Info	[217], [218], [219]
D1682		Vardenafil	C23H32N6O4S	135400189	Moderate		Inter Info	[290], [291], [292]
D1716		Zaleplon	C17H15N5O	5719	Moderate		Inter Info	[217], [218], [219]
D1625		Treprostinil	C23H34O5	6918140	Moderate		Inter Info	[12], [313], [314]
D1638		Triflupromazine	C18H19F3N2S	5568	Moderate		Inter Info	[259], [260], [261], [262], [263], [264], [265], [266], [267], [268], [269]
D1726		Ziprasidone	C21H21ClN4OS	60854	Moderate		Inter Info	[259], [260], [261], [262], [263], [264], [265], [266], [267], [268], [269]
D1729		Zolpidem	C19H21N3O	5732	Moderate		Inter Info	[217], [218], [219]
D0069		Amlodipine	C20H25ClN2O5	2162	Minor		Inter Info	[234], [361], [362]
D0497		Diltiazem	C22H26N2O4S	39186	Minor		Inter Info	[234], [361], [362]
D0865		Isradipine	C19H21N3O5	3784	Minor		Inter Info	[234], [361], [362]
D1141		Nisoldipine	C20H24N2O6	4499	Minor		Inter Info	[234], [361], [362]
D0640		Felodipine	C18H19Cl2NO4	3333	Minor		Inter Info	[234], [361], [362]
D0711		Garlic	NA	NA	Minor		Inter Info	[368], [369]
D0911		Levamlodipine	C20H25ClN2O5	9822750	Minor		Inter Info	[234], [361], [362]
D1130		Nicardipine	C26H29N3O6	4474	Minor		Inter Info	[234], [361], [362]
D1134		Nifedipine	C17H18N2O6	4485	Minor		Inter Info	[234], [361], [362]
D1527		Tadalafil	C22H19N3O4	110635	Minor		Inter Info	[372], [373]
D1690		Verapamil	C27H38N2O4	2520	Minor		Inter Info	[234], [361], [362]
	Additive myelosuppressive effects					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0821		Interferon alfa-2a, Recombinant	NA	NA	Moderate		Inter Info	[82], [283], [284]
	Increased risk of angioedema/anaphylactoid reactions					Drug Num: 13
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0040		Allopurinol	C5H4N4O	135401907	Major		Inter Info	[1], [2], [3]
D0848		Iron Dextran	FeH2O4S	105075	Major		Inter Info	[64], [65], [66]
D0047		Alteplase	NA	NA	Moderate		Inter Info	[220], [12], [221]
D0088		Anistreplase	NA	NA	Moderate		Inter Info	[220], [12], [221]
D1335		Pregabalin	C8H17NO2	5486971	Moderate		Inter Info	[12], [289], [82]
D1395		Reteplase	NA	NA	Moderate		Inter Info	[220], [12], [221]
D1506		Streptokinase	C11H19NO2	9815560	Moderate		Inter Info	[220], [12], [221]
D1550		Tenecteplase	NA	NA	Moderate		Inter Info	[220], [12], [221]
D0629		Everolimus	C53H83NO14	6442177	Moderate		Inter Info	[315], [316], [317]
D1787		Fluorescein	C20H12O5	16850	Moderate		Inter Info	[82], [283], [318]
D1476		Sirolimus	C51H79NO13	5284616	Moderate		Inter Info	[315], [316], [317]
D1549		Temsirolimus	C56H87NO16	6918289	Moderate		Inter Info	[315], [316], [317]
D1669		Urokinase	NA	NA	Moderate		Inter Info	[220], [12], [221]
	Increased risk of hepatotoxicity					Drug Num: 22
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0900		Leflunomide	C12H9F3N2O2	3899	Major		Inter Info	[67], [68], [69]
D0944		Lomitapide	C39H37F6N3O2	9853053	Major		Inter Info	[73]
D1073		Mipomersen	C230H324N67O122P19S19	118984467	Major		Inter Info	[74]
D1258		Pexidartinib	C20H15ClF3N5	25151352	Major		Inter Info	[76]
D1556		Teriflunomide	C12H9F3N2O2	54684141	Major		Inter Info	[67], [68], [69]
D0114		Asparaginase Escherichia coli	NA	NA	Moderate		Inter Info	[222], [223], [224], [220], [12], [225], [226], [227], [228], [229], [230], [231], [232]
D0584		Epirubicin	C27H29NO11	41867	Moderate		Inter Info	[220], [12], [275]
D0826		Interferon beta-1a	NA	NA	Moderate		Inter Info	[285], [286], [287], [288]
D0827		Interferon beta-1b	NA	NA	Moderate		Inter Info	[285], [286], [287], [288]
D1234		Pegaspargase	C14H19NO	436058	Moderate		Inter Info	[222], [223], [224], [220], [12], [225], [226], [227], [228], [229], [230], [231], [232]
D1589		Tioguanine	C5H5N5S	2723601	Moderate		Inter Info	[293], [294]
D0113		Asparaginase Erwinia chrysanthemi	NA	NA	Moderate		Inter Info	[222], [223], [224], [220], [12], [225], [226], [227], [228], [229], [230], [231], [232]
D0149		Bedaquiline	C32H31BrN2O2	5388906	Moderate		Inter Info	[299]
D0199		Brentuximab vedotin	NA	NA	Moderate		Inter Info	[300]
D0232		Calaspargase pegol	NA	NA	Moderate		Inter Info	[222], [223], [224], [220], [12], [225], [226], [227], [228], [229], [230], [231], [232]
D0554		Efavirenz	C14H9ClF3NO2	64139	Moderate		Inter Info	[310], [311]
D0789		Idelalisib	C22H18FN7O	11625818	Moderate		Inter Info	[320]
D1025		Methotrexate	C20H22N8O5	126941	Moderate		Inter Info	[12], [342]
D1106		Naltrexone	C20H23NO4	5360515	Moderate		Inter Info	[343]
D1239		Peginterferon beta-1a	NA	NA	Moderate		Inter Info	[285], [286], [287], [288]
D1389		Remdesivir	C27H35N6O8P	121304016	Moderate		Inter Info	[220], [12], [355], [356], [357]
D1615		Trabectedin	C39H43N3O11S	108150	Moderate		Inter Info	[12], [360]
	Increased risk of hyperkalemia					Drug Num: 27
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1170		Olmesartan	C24H26N6O3	158781	Major		Inter Info	[4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19]
D1501		Spironolactone	C24H32O4S	5833	Major		Inter Info	[20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60]
D0038		Aliskiren	C30H53N3O6	5493444	Major		Inter Info	[61], [62], [13], [10], [8], [63]
D0058		Amiloride	C6H8ClN7O	16231	Major		Inter Info	[20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60]
D0138		Azilsartan medoxomil	C30H24N4O8	135409642	Major		Inter Info	[4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19]
D0587		Eprosartan	C23H24N2O4S	5281037	Major		Inter Info	[4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19]
D0844		Irbesartan	C25H28N6O	3749	Major		Inter Info	[5], [6], [9], [7], [19], [16], [4], [11], [13], [15], [17], [18], [8], [10], [12], [14]
D0954		Losartan	C22H23ClN6O	3961	Major		Inter Info	[4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19]
D1086		Monopotassium phosphate	H2KO4P	516951	Major		Inter Info	[38], [75], [44]
D1316		Potassium acetate	C2H3KO2	517044	Major		Inter Info	[44], [39], [34], [25], [31], [33], [51], [77], [50], [78], [79], [27], [80], [23], [24], [20], [81], [35], [53], [37], [75], [38], [82], [59]
D1317		Potassium bicarbonate	CHKO3	516893	Major		Inter Info	[44], [39], [34], [25], [31], [33], [51], [77], [50], [78], [79], [27], [80], [23], [24], [20], [81], [35], [53], [37], [75], [38], [82], [59]
D1318		Potassium chloride	ClK	4873	Major		Inter Info	[44], [39], [34], [25], [31], [33], [51], [77], [50], [78], [79], [27], [80], [23], [24], [20], [81], [35], [53], [37], [75], [38], [82], [59]
D1319		Potassium citrate	C6H5K3O7	13344	Major		Inter Info	[44], [39], [34], [25], [31], [33], [51], [77], [50], [78], [79], [27], [80], [23], [24], [20], [81], [35], [53], [37], [75], [38], [82], [59]
D1320		Potassium gluconate	C6H11KO7	16760467	Major		Inter Info	[44], [39], [34], [25], [31], [33], [51], [77], [50], [78], [79], [27], [80], [23], [24], [20], [81], [35], [53], [37], [75], [38], [82], [59]
D1321		Potassium Iodide	IK	4875	Major		Inter Info	[44], [39], [34], [25], [31], [33], [51], [77], [50], [78], [79], [27], [80], [23], [24], [20], [81], [35], [53], [37], [75], [38], [82], [59]
D1545		Telmisartan	C33H30N4O2	65999	Major		Inter Info	[4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19]
D1631		Triamterene	C12H11N7	5546	Major		Inter Info	[20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60]
D1645		Trimethoprim	C14H18N4O3	5578	Major		Inter Info	[84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [51], [78], [98], [99], [100], [101], [102], [103], [104], [25], [26], [105], [50], [40], [106], [107], [108], [109], [110], [111], [112]
D1679		Valsartan	C24H29N5O3	60846	Major		Inter Info	[4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19]
D0414		Dalteparin	C26H42N2O37S5	772	Moderate		Inter Info	[4], [5], [302], [11], [303], [12], [304], [50], [305], [306]
D0536		Drospirenone	C24H30O3	68873	Moderate		Inter Info	[309], [27]
D0574		Enoxaparin	C26H42N2O37S5	772	Moderate		Inter Info	[4], [5], [302], [11], [303], [12], [304], [50], [305], [306]
D0585		Eplerenone	C24H30O6	443872	Moderate		Inter Info	[312], [40]
D0753		Heparin	C26H42N2O37S5	772	Moderate		Inter Info	[5], [4], [12], [304], [306], [11], [305], [303], [50], [302]
D1526		Tacrolimus	C44H69NO12	445643	Moderate		Inter Info	[50], [12]
D1588		Tinzaparin	C26H42N2O37S5	772	Moderate		Inter Info	[4], [5], [302], [11], [303], [12], [304], [50], [305], [306]
D1608		Tolvaptan	C26H25ClN2O3	216237	Moderate		Inter Info	[359]
	Increased risk of hypoglycemia					Drug Num: 19
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0013		Acetohexamide	C15H20N2O4S	1989	Moderate		Inter Info	[113], [114], [115], [116], [117], [118], [119], [120], [121], [122], [123], [124], [125], [126], [127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [137], [138], [139], [140], [141], [142], [143], [144], [145], [146], [147], [148], [149], [150], [151], [152], [153], [154], [155], [156], [157], [158], [159], [160], [161], [162], [163], [164], [165], [166], [167], [168], [169], [170], [171], [172], [173], [174], [175], [176], [177], [178], [179], [180], [181], [182], [183], [184], [185], [186], [187], [188], [189], [190], [191], [192], [193], [194], [195], [196], [197], [198], [199], [200], [201], [202], [203], [204], [205], [206], [207], [208], [209], [210], [211], [212], [213]
D0727		Glimepiride	C24H34N4O5S	3476	Moderate		Inter Info	[113], [114], [115], [116], [117], [118], [119], [120], [121], [122], [123], [124], [125], [126], [127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [137], [138], [139], [140], [141], [142], [143], [144], [145], [146], [147], [148], [149], [150], [151], [152], [153], [154], [155], [156], [157], [158], [159], [160], [161], [162], [163], [164], [165], [166], [167], [168], [169], [170], [171], [172], [173], [174], [175], [176], [177], [178], [179], [180], [181], [182], [183], [184], [185], [186], [187], [188], [189], [190], [191], [192], [193], [194], [195], [196], [197], [198], [199], [200], [201], [202], [203], [204], [205], [206], [207], [208], [209], [210], [211], [212], [213]
D0811		Insulin glargine	C267H404N72O78S6	118984454	Moderate		Inter Info	[113], [114], [115], [116], [117], [118], [119], [120], [121], [122], [123], [276], [124], [125], [126], [127], [128], [129], [130], [131], [133], [134], [135], [137], [138], [139], [140], [142], [143], [144], [146], [148], [149], [150], [151], [152], [153], [154], [155], [156], [158], [161], [163], [164], [165], [168], [169], [171], [172], [173], [175], [277], [177], [278], [279], [182], [280], [281], [188], [190], [191], [192], [194], [196], [198], [200], [201], [205], [206], [207], [208], [282], [209], [210], [212], [213]
D0813		Insulin human	C257H383N65O77S6	118984375	Moderate		Inter Info	[120], [177], [194]
D0814		Insulin human (inhalation, rapid acting)	C257H383N65O77S6	118984375	Moderate		Inter Info	[120], [177], [194]
D0815		Insulin human (isophane)	C257H383N65O77S6	118984375	Moderate		Inter Info	[120], [177], [194]
D0817		Insulin human (zinc extended)	C257H383N65O77S6	118984375	Moderate		Inter Info	[120], [177], [194]
D0819		Insulin lispro	C257H389N65O77S6	16132438	Moderate		Inter Info	[113], [114], [115], [116], [117], [118], [119], [120], [121], [122], [123], [276], [124], [125], [126], [127], [128], [129], [130], [131], [133], [134], [135], [137], [138], [139], [140], [142], [143], [144], [146], [148], [149], [150], [151], [152], [153], [154], [155], [156], [158], [161], [163], [164], [165], [168], [169], [171], [172], [173], [175], [277], [177], [278], [279], [182], [280], [281], [188], [190], [191], [192], [194], [196], [198], [200], [201], [205], [206], [207], [208], [282], [209], [210], [212], [213]
D0325		Chlorpropamide	C10H13ClN2O3S	2727	Moderate		Inter Info	[113], [114], [115], [116], [117], [118], [119], [120], [121], [122], [123], [124], [125], [126], [127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [137], [138], [139], [140], [141], [142], [143], [144], [145], [146], [147], [148], [149], [150], [151], [152], [153], [154], [155], [156], [157], [158], [159], [160], [161], [162], [163], [164], [165], [166], [167], [168], [169], [170], [171], [172], [173], [174], [175], [176], [177], [178], [179], [180], [181], [182], [183], [184], [185], [186], [187], [188], [189], [190], [191], [192], [193], [194], [195], [196], [197], [198], [199], [200], [201], [202], [203], [204], [205], [206], [207], [208], [209], [210], [211], [212], [213]
D0728		Glipizide	C21H27N5O4S	3478	Moderate		Inter Info	[113], [114], [115], [116], [117], [118], [119], [120], [121], [122], [123], [124], [125], [126], [127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [137], [138], [139], [140], [141], [142], [143], [144], [145], [146], [147], [148], [149], [150], [151], [152], [153], [154], [155], [156], [157], [158], [159], [160], [161], [162], [163], [164], [165], [166], [167], [168], [169], [170], [171], [172], [173], [174], [175], [176], [177], [178], [179], [180], [181], [182], [183], [184], [185], [186], [187], [188], [189], [190], [191], [192], [193], [194], [195], [196], [197], [198], [199], [200], [201], [202], [203], [204], [205], [206], [207], [208], [209], [210], [211], [212], [213]
D0730		Glyburide	C23H28ClN3O5S	3488	Moderate		Inter Info	[113], [114], [115], [116], [117], [118], [119], [120], [121], [122], [123], [124], [125], [126], [127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [137], [138], [139], [140], [141], [142], [143], [144], [145], [146], [147], [148], [149], [150], [151], [152], [153], [154], [155], [156], [157], [158], [159], [160], [161], [162], [163], [164], [165], [166], [167], [168], [169], [170], [171], [172], [173], [174], [175], [176], [177], [178], [179], [180], [181], [182], [183], [184], [185], [186], [187], [188], [189], [190], [191], [192], [193], [194], [195], [196], [197], [198], [199], [200], [201], [202], [203], [204], [205], [206], [207], [208], [209], [210], [211], [212], [213]
D0807		Insulin aspart (aspart protamine)	C256H381N65O79S6	118984445	Moderate		Inter Info	[120], [177], [194]
D0808		Insulin aspart (aspart)	C256H381N65O79S6	118984445	Moderate		Inter Info	[120], [177], [194]
D0809		Insulin degludec	C274H411N65O81S6	118984462	Moderate		Inter Info	[113], [114], [115], [116], [117], [118], [119], [120], [121], [122], [123], [276], [124], [125], [126], [127], [128], [129], [130], [131], [133], [134], [135], [137], [138], [139], [140], [142], [143], [144], [146], [148], [149], [150], [151], [152], [153], [154], [155], [156], [158], [161], [163], [164], [165], [168], [169], [171], [172], [173], [175], [277], [177], [278], [279], [182], [280], [281], [188], [190], [191], [192], [194], [196], [198], [200], [201], [205], [206], [207], [208], [282], [209], [210], [212], [213]
D0810		Insulin detemir	C267H402N64O76S6	16137271	Moderate		Inter Info	[113], [114], [115], [116], [117], [118], [119], [120], [121], [122], [123], [276], [124], [125], [126], [127], [128], [129], [130], [131], [133], [134], [135], [137], [138], [139], [140], [142], [143], [144], [146], [148], [149], [150], [151], [152], [153], [154], [155], [156], [158], [161], [163], [164], [165], [168], [169], [171], [172], [173], [175], [277], [177], [278], [279], [182], [280], [281], [188], [190], [191], [192], [194], [196], [198], [200], [201], [205], [206], [207], [208], [282], [209], [210], [212], [213]
D0812		Insulin glulisine	C258H384N64O78S6	16136701	Moderate		Inter Info	[113], [114], [115], [116], [117], [118], [119], [120], [121], [122], [123], [276], [124], [125], [126], [127], [128], [129], [130], [131], [133], [134], [135], [137], [138], [139], [140], [142], [143], [144], [146], [148], [149], [150], [151], [152], [153], [154], [155], [156], [158], [161], [163], [164], [165], [168], [169], [171], [172], [173], [175], [277], [177], [278], [279], [182], [280], [281], [188], [190], [191], [192], [194], [196], [198], [200], [201], [205], [206], [207], [208], [282], [209], [210], [212], [213]
D1392		Repaglinide	C27H36N2O4	65981	Moderate		Inter Info	[113], [114], [115], [116], [117], [118], [119], [120], [121], [122], [123], [124], [125], [126], [127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [137], [138], [139], [140], [141], [142], [143], [144], [145], [146], [147], [148], [149], [150], [151], [152], [153], [154], [155], [156], [157], [158], [159], [160], [161], [162], [163], [164], [165], [166], [167], [168], [169], [170], [171], [172], [173], [174], [175], [176], [177], [178], [179], [180], [181], [182], [183], [184], [185], [186], [187], [188], [189], [190], [191], [192], [193], [194], [195], [196], [197], [198], [199], [200], [201], [202], [203], [204], [205], [206], [207], [208], [209], [210], [211], [212], [213]
D1601		Tolazamide	C14H21N3O3S	5503	Moderate		Inter Info	[113], [114], [115], [116], [117], [118], [119], [120], [121], [122], [123], [124], [125], [126], [127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [137], [138], [139], [140], [141], [142], [143], [144], [145], [146], [147], [148], [149], [150], [151], [152], [153], [154], [155], [156], [157], [158], [159], [160], [161], [162], [163], [164], [165], [166], [167], [168], [169], [170], [171], [172], [173], [174], [175], [176], [177], [178], [179], [180], [181], [182], [183], [184], [185], [186], [187], [188], [189], [190], [191], [192], [193], [194], [195], [196], [197], [198], [199], [200], [201], [202], [203], [204], [205], [206], [207], [208], [209], [210], [211], [212], [213]
D1603		Tolbutamide	C12H18N2O3S	5505	Moderate		Inter Info	[113], [114], [115], [116], [117], [118], [119], [120], [121], [122], [123], [124], [125], [126], [127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [137], [138], [139], [140], [141], [142], [143], [144], [145], [146], [147], [148], [149], [150], [151], [152], [153], [154], [155], [156], [157], [158], [159], [160], [161], [162], [163], [164], [165], [166], [167], [168], [169], [170], [171], [172], [173], [174], [175], [176], [177], [178], [179], [180], [181], [182], [183], [184], [185], [186], [187], [188], [189], [190], [191], [192], [193], [194], [195], [196], [197], [198], [199], [200], [201], [202], [203], [204], [205], [206], [207], [208], [209], [210], [211], [212], [213]
	Increased risk of nephrotoxicity					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0402		Cyclosporine	C62H111N11O12	5284373	Moderate		Inter Info	[220], [12], [270], [50], [271]
	Increased risk of other adverse reactions (Unspecific)					Drug Num: 3
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1287		Picosulfuric acid	C18H15NO8S2	5243	Moderate		Inter Info	[4], [353], [354]
D1308		Polyethylene glycol (3350 with electrolytes)	C2H6O2	174	Moderate		Inter Info	[4], [353], [354]
D1757		Capsaicin (topical)	C18H27NO3	1548943	Minor		Inter Info	[82], [366], [367]
Pharmacodynamic antagonistic effects
	Antagonize the effect of antihypertensive agents					Drug Num: 39
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0172		Betamethasone	C22H29FO5	9782	Moderate		Inter Info	[12], [252]
D0298		Celecoxib	C17H14F3N3O2S	2662	Moderate		Inter Info	[256], [257], [258]
D0800		Indomethacin	C19H16ClNO4	3715	Moderate		Inter Info	[256], [257], [258]
D0882		Ketorolac	C15H13NO3	3826	Moderate		Inter Info	[256], [257], [258]
D1097		Nabumetone	C15H16O2	4409	Moderate		Inter Info	[256], [257], [258]
D1606		Tolmetin	C15H15NO3	5509	Moderate		Inter Info	[256], [257], [258]
D0210		Bromfenac	C15H12BrNO3	60726	Moderate		Inter Info	[256], [257], [258]
D0215		Budesonide	C25H34O6	5281004	Moderate		Inter Info	[12], [252]
D0331		Choline salicylate	C12H19NO4	54686350	Moderate		Inter Info	[256], [257], [258]
D0392		Corticotropin	C207H308N56O58S	16132265	Moderate		Inter Info	[12], [252]
D0436		Deflazacort	C25H31NO6	189821	Moderate		Inter Info	[12], [252]
D0476		Diclofenac	C14H11Cl2NO2	3033	Moderate		Inter Info	[256], [257], [258]
D0489		Diflunisal	C13H8F2O3	3059	Moderate		Inter Info	[256], [257], [258]
D0624		Etodolac	C17H21NO3	3308	Moderate		Inter Info	[256], [257], [258]
D0645		Fenoprofen	C15H14O3	3342	Moderate		Inter Info	[256], [257], [258]
D0671		Fludrocortisone	C21H29FO5	31378	Moderate		Inter Info	[12], [252]
D0680		Flurbiprofen	C15H13FO2	3394	Moderate		Inter Info	[256], [257], [258]
D0773		Hydrocortisone	C21H30O5	5754	Moderate		Inter Info	[12], [252]
D0786		Ibuprofen	C13H18O2	3672	Moderate		Inter Info	[256], [257], [258]
D1814		Icatibant	C59H89N19O13S	6918173	Moderate		Inter Info	[12], [307], [319]
D0881		Ketoprofen	C16H14O3	3825	Moderate		Inter Info	[256], [257], [258]
D0926		Licorice	C42H62O16Zn	163463	Moderate		Inter Info	[338], [339], [340]
D0988		Meclofenamic acid	C14H11Cl2NO2	4037	Moderate		Inter Info	[256], [257], [258]
D0991		Mefenamic acid	C15H15NO2	4044	Moderate		Inter Info	[256], [257], [258]
D0995		Meloxicam	C14H13N3O4S2	54677470	Moderate		Inter Info	[256], [257], [258]
D1041		Methylprednisolone	C22H30O5	6741	Moderate		Inter Info	[12], [252]
D1109		Naproxen	C14H14O3	156391	Moderate		Inter Info	[256], [257], [258]
D1196		Oxaprozin	C18H15NO3	4614	Moderate		Inter Info	[256], [257], [258]
D1272		Phenyl salicylate	C13H10O3	8361	Moderate		Inter Info	[256], [257], [258]
D1274		Phenylbutazone	C19H20N2O2	4781	Moderate		Inter Info	[256], [257], [258]
D1300		Piroxicam	C15H13N3O4S	54676228	Moderate		Inter Info	[256], [257], [258]
D1334		Prednisone	C21H26O5	5865	Moderate		Inter Info	[12], [252]
D1421		Rofecoxib	C17H14O4S	5090	Moderate		Inter Info	[256], [257], [258]
D1439		Salicylic acid (sodium)	C7H6O3	338	Moderate		Inter Info	[256], [257], [258]
D1442		Salsalate	C14H10O5	5161	Moderate		Inter Info	[256], [257], [258]
D1520		Sulindac	C20H17FO3S	1548887	Moderate		Inter Info	[256], [257], [258]
D1563		Tetracosactide	C136H210N40O31S	16133802	Moderate		Inter Info	[12], [252]
D1628		Triamcinolone	C21H27FO6	31307	Moderate		Inter Info	[12], [252]
D1674		Valdecoxib	C16H14N2O3S	119607	Moderate		Inter Info	[256], [257], [258]
	Attenuated pharmacological effects (Unspecific)					Drug Num: 3
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0423		Darbepoetin alfa	NA	NA	Minor		Inter Info	[82], [363], [364]
D0598		Erythropoietin	C22H22ClKN6O	11751549	Minor		Inter Info	[82], [363], [364]
D1236		Peginesatide	NA	NA	Minor		Inter Info	[82], [363], [364]

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229	Product Information. Elspar (asparaginase). Merck & Co, Inc, West Point, PA.
230	Product Information. Erwinaze (asparaginase Erwinia chrysanthemi). EUSA Pharma, Newtown, PA.
231	Product Information. Oncaspar (pegaspargase). Rhone-Poulenc Rorer, Collegeville, PA.
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246	Product Information. Vasotec (enalapril). Merck & Co, Inc, West Point, PA.
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267	Product Information. Seroquel (quetiapine). Zeneca Pharmaceuticals, Wilmington, DE.
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281	Product Information. Tresiba FlexTouch (insulin degludec). Novo Nordisk Pharmaceuticals Inc, Princeton, NJ.
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286	Product Information. Betaseron (interferon beta-1b). Berlex, Richmond, CA.
287	Product Information. Plegridy (peginterferon beta-1a). Biogen Idec Inc, Cambridge, MA.
288	Product Information. Rebif (interferon beta-1a). Serono Laboratories Inc, Norwell, MA.
289	Product Information. Lyrica (pregabalin). Pfizer U.S. Pharmaceuticals Group, New York, NY.
290	Product Information. Levitra (vardenafil). Bayer, West Haven, CT.
291	Product Information. Stendra (avanafil). Vivus Inc, Mountain View, CA.
292	Product Information. Viagra (sildenafil). Pfizer US Pharmaceuticals, New York, NY.
293	Product Information. Aubagio (teriflunomide). Genzyme Corporation, Cambridge, MA.
294	Product Information. Tabloid (thioguanine). Prasco Laboratories, Cincinnati, OH.
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300	Product Information. Adcetris (brentuximab vedotin). Seattle Genetics Inc, Bothell, WA.
301	Product Information. Jardiance (empagliflozin). Boehringer Ingelheim, Ridgefield, CT.
302	Product Information. Avapro (irbesartan). Bristol-Myers Squibb, Princeton, NJ.
303	Product Information. Teveten (eprosartan). SmithKline Beecham, Philadelphia, PA.
304	Product Information. Cozaar (losartan). Merck & Co, Inc, West Point, PA.
305	Product Information. Edarbi (azilsartan). Takeda Pharmaceuticals America, Lincolnshire, IL.
306	Product Information. Benicar (olmesartan). Sankyo Parke Davis, Parsippany, NJ.
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309	Product Information. Yasmin (drospirenone-ethinyl estradiol) Berlex Laboratories, Richmond, CA.
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312	Product Information. Inspra (eplerenone). Searle, Chicago, IL.
313	Product Information. Flolan (epoprostenol). Glaxo Wellcome, Research Triangle Park, NC.
314	Product Information. Remodulin (treprostinil). United Therapeutics Corp, Silver Spring, MD.
315	Product Information. Afinitor (everolimus). Novartis Pharmaceuticals, East Hanover, NJ.
316	Product Information. Rapamune (sirolimus) Wyeth-Ayerst Laboratories, Philadelphia, PA.
317	Product Information. Torisel (temsirolimus). Wyeth-Ayerst Laboratories, Philadelphia, PA.
318	Product Information. AK-Fluor (fluorescein). Akorn Inc, Buffalo Grove, IL.
319	Product Information. Firazyr (icatibant). Shire US Inc, Florence, KY.
320	Product Information. Zydelig (idelalisib). Gilead Sciences, Foster City, CA.
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327	Product Information. Marplan (isocarboxazid) Roche Laboratories, Nutley, NJ.
328	Product Information. Matulane (procarbazine). Roche Laboratories, Nutley, NJ.
329	Product Information. Nardil (phenelzine). Parke-Dvis, Morris Plains, NJ.
330	Product Information. Parnate (tranylcypromine). SmithKline Beecham, Philadelphia, PA.
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334	Product Information. Fosrenol (lanthanum carbonate). Shire US Inc, Florence, KY.
335	Product Information. Nuzyra (omadacycline). Paratek Pharmaceuticals, Inc., Boston, MA.
336	Product Information. Seysara (sarecycline). Allergan Inc, Irvine, CA.
337	Product Information. Stalevo 150 (carbidopa/entacapone/levodopa). Novartis Pharmaceuticals, East Hanover, NJ.
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341	Product Information. Selzentry (maraviroc). Pfizer U.S. Pharmaceuticals Group, New York, NY.
342	Product Information. Methotrexate (methotrexate). Lederle Laboratories, Wayne, NJ.
343	Product Information. ReVia (naltrexone). DuPont Pharmaceuticals, Wilmington, DE.
344	Product Information. Fycompa (perampanel). Eisai Inc, Teaneck, NJ.
345	Product Information. Serzone (nefazodone). Bristol-Myers Squibb, Princeton, NJ.
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350	Product Information. Sodium Nitrite (sodium nitrite). Hope Pharmaceuticals, Scottsdale, AZ.
351	Product Information. Patanase (olopatadine nasal). Alcon Laboratories Inc, Fort Worth, TX.
352	Product Information. Trental (pentoxifylline). Hoechst Marion-Roussel Inc, Kansas City, MO.
353	Product Information. Suclear (polyethylene glycol 3350 with electrolytes). Braintree Laboratories, Braintree, MA.
354	Product Information. Suprep Bowel Prep Kit (magnesium/potassium/sodium sulfates). Braintree Laboratories, Braintree, MA.
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359	Product Information. Samsca (tolvaptan). Otsuka American Pharmaceuticals Inc, Rockville, MD.
360	Product Information. Yondelis (trabectedin). Janssen Pharmaceuticals, Titusville, NJ.
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372	Product Information. Cialis (tadalafil). Lilly, Eli and Company, Indianapolis, IN.
373	Product Information. Rapaflo (silodosin). Watson Pharmaceuticals, Corona, CA.

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