Drug General Information (ID: DDIWISOLFU)
  Drug Name Trandolapril Drug Info Sodium citrate Drug Info
  Drug Type Small molecule Small molecule
  Therapeutic Class Antihypertensive Agents Minerals And Electrolytes
  Structure

 Mechanism of Trandolapril-Sodium citrate Interaction (Severity Level: Minor)
     Altered gastric pH Click to Show/Hide Mechanism Graph
Could Not Find 2D Structure
      Drug Name Trandolapril Sodium citrate
      Mechanism Gastric pH sensitive Gastric alkalinizer
      Key Mechanism Factor 1
Factor Name Gastric pH
Factor Description The normal pH range of gastric acid is between 1.5 and 3.5 and is highly acidic, consisting mainly of hydrochloric acid. Changes in the pH of the stomach can alter the absorption of drugs.
      Mechanism Description
  • Decreased absorption of Trandolapril due to altered gastric pH caused by Sodium citrate 

References
1 Mantyla R, Mannisto PT, Vuorela A, Sundberg S, Ottoila P "Impairment of captopril bioavailability by concomitant food and antacid intake." Int J Clin Pharmacol Ther Toxicol 22 (1984): 626-9. [PMID: 6389377]