Drug General Information (ID: DDIZREMX8O)
  Drug Name Trandolapril Drug Info Magnesium carbonate Drug Info
  Drug Type Small molecule Small molecule
  Therapeutic Class Antihypertensive Agents Antacids
  Structure

 Mechanism of Trandolapril-Magnesium carbonate Interaction (Severity Level: Minor)
     Altered gastric pH Click to Show/Hide Mechanism Graph
Could Not Find 2D Structure
      Drug Name Trandolapril Magnesium carbonate
      Mechanism Gastric pH sensitive Gastric alkalinizer
      Key Mechanism Factor 1
Factor Name Gastric pH
Factor Description The normal pH range of gastric acid is between 1.5 and 3.5 and is highly acidic, consisting mainly of hydrochloric acid. Changes in the pH of the stomach can alter the absorption of drugs.
      Mechanism Description
  • Decreased absorption of Trandolapril due to altered gastric pH caused by Magnesium carbonate 

References
1 Mantyla R, Mannisto PT, Vuorela A, Sundberg S, Ottoila P "Impairment of captopril bioavailability by concomitant food and antacid intake." Int J Clin Pharmacol Ther Toxicol 22 (1984): 626-9. [PMID: 6389377]