Drug General Information (ID: DDI68Q3FOW)
Drug Name			Trandolapril		Drug Info		Capsaicin (topical)		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antihypertensive Agents				Topical Analgesic Agent
Structure

Mechanism of Trandolapril-Capsaicin (topical) Interaction (Severity Level: Minor)
Increased risk of other adverse reactions (Unspecific) Click to Show/Hide Mechanism Graph
Drug Name		Trandolapril				Capsaicin (topical)
Mechanism		Cough				Cough
Key Mechanism Factor 1
		Factor Name		Adverse reactions
		Factor Description		An adverse reaction is an unexpected negative reaction to a medication or treatment that happens even when it's used correctly.
Mechanism Description		Increased risk of adverse reactions by the combination of Trandolapril and Capsaicin (topical)

References
1	Ray K, Dorman S, Watson R "Severe hyperkalaemia due to the concomitant use of salt substitutes and ACE inhibitors in hypertension: a potentially life threatening interaction." J Hum Hypertens 13 (1999): 717-20. [PMID: 10516744]
2	Morice AH, Brown MJ, Lowry R, Higenbottam T "Angiotensin-converting enzyme and the cough reflex." Lancet 2 (1987): 1116-8. [PMID: 2890021]
3	Hakas JF Jr "Topical capsaicin induces cough in patient receiving ACE inhibitor." Ann Allergy 65 (1990): 322-3. [PMID: 2221491]