Details of Drug

Drug General Information (ID: D1757)
Drug Name	Capsaicin (topical)
Drug Type	Small molecule
Drug Synonymous	Capsaicin (transdermal patch formulation, neuropathic pain) Click to Show/Hide
Disease Class	8E43: General pain disorder
Therapeutic Class	Topical Analgesic Agent
Structure
Structure	3D Structure		2D Structure
Formula	C18H27NO3
InChI	1S/C18H27NO3/c1-14(2)8-6-4-5-7-9-18(21)19-13-15-10-11-16(20)17(12-15)22-3/h6,8,10-12,14,20H,4-5,7,9,13H2,1-3H3,(H,19,21)/b8-6+
InChIKey	YKPUWZUDDOIDPM-SOFGYWHQSA-N
Canonical SMILES	CC(C)C=CCCCCC(=O)NCC1=CC(=C(C=C1)O)OC
External Link
	Pubchem ID	1548943
	CAS Number	CAS 404-86-4
	CHEBI ID	CHEBI:3374
	TTD ID	D0U5CE
	INTEDE ID	DR0268

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM006 Pharmacodynamic additive effects BM109 Increased risk of other adverse reactions (Unspecific)
Relation Graph

Full list of drugs interacting with Capsaicin (topical)
Pharmacodynamic additive effects
	Increased risk of other adverse reactions (Unspecific)					Drug Num: 10
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0156		Benazepril	C24H28N2O5	5362124	Minor		Inter Info	[1], [2], [3]
D0254		Captopril	C9H15NO3S	44093	Minor		Inter Info	[1], [2], [3]
D0567		Enalapril	C20H28N2O5	5388962	Minor		Inter Info	[1], [2], [3]
D0695		Fosinopril	C30H46NO7P	55891	Minor		Inter Info	[1], [2], [3]
D0938		Lisinopril	C21H31N3O5	5362119	Minor		Inter Info	[1], [2], [3]
D1082		Moexipril	C27H34N2O7	91270	Minor		Inter Info	[1], [2], [3]
D1256		Perindopril	C19H32N2O5	107807	Minor		Inter Info	[1], [2], [3]
D1369		Quinapril	C25H30N2O5	54892	Minor		Inter Info	[1], [2], [3]
D1379		Ramipril	C23H32N2O5	5362129	Minor		Inter Info	[1], [2], [3]
D1618		Trandolapril	C24H34N2O5	5484727	Minor		Inter Info	[1], [2], [3]

References
1	Ray K, Dorman S, Watson R "Severe hyperkalaemia due to the concomitant use of salt substitutes and ACE inhibitors in hypertension: a potentially life threatening interaction." J Hum Hypertens 13 (1999): 717-20. [PMID: 10516744]
2	Morice AH, Brown MJ, Lowry R, Higenbottam T "Angiotensin-converting enzyme and the cough reflex." Lancet 2 (1987): 1116-8. [PMID: 2890021]
3	Hakas JF Jr "Topical capsaicin induces cough in patient receiving ACE inhibitor." Ann Allergy 65 (1990): 322-3. [PMID: 2221491]