Drug General Information (ID: DDIU26Q9WN)
Drug Name			Darbepoetin alfa		Drug Info		Trandolapril		Drug Info
Drug Type		Protein/peptide				Small molecule
Therapeutic Class		Antianemic Agents				Antihypertensive Agents

Mechanism of Darbepoetin alfa-Trandolapril Interaction (Severity Level: Minor)
Attenuated pharmacological effects (Unspecific) Click to Show/Hide Mechanism Graph
Drug Name		Darbepoetin alfa				Trandolapril
Mechanism		Erythropoiesis-stimulating agent				Interfere with the effects of erythropoietin
Key Mechanism Factor 1
		Factor Name		Pharmacodynamics
		Factor Description		Reduced pharmacological effects leading to insufficient efficacy and/or treatment failure.
Mechanism Description		Attenuated pharmacological effects of  Darbepoetin alfa when combined with Trandolapril

References
1	Ray K, Dorman S, Watson R "Severe hyperkalaemia due to the concomitant use of salt substitutes and ACE inhibitors in hypertension: a potentially life threatening interaction." J Hum Hypertens 13 (1999): 717-20. [PMID: 10516744]
2	Walter J "Does captopril decrease the effect of human recombinant erythropoietin in hemodialysis patients?" Nephrol Dial Transplant 8 (1993): 1428-31
3	Conlon PJ, Albers F, Butterly D, Schwab SJ "ACE inhibitors do not affect erythropoietin efficacy in haemodialysis patients." Nephrol Dial Transplant 9 (1994): 1358