Details of Drug

Details of Drug

 Drug General Information (ID: D0423)
  Drug Name
Darbepoetin alfa
  Drug Type Protein/peptide
  Drug Synonymous
Aranesp (TN)
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  Disease Class 3A00-3A9Z: Anemia
  Therapeutic Class Antianemic Agents
  External Link
TTD ID D02LVZ

Drug-Drug Interaction Network
  Sunburst Graph
AM006  Pharmacodynamic additive effects
AM007  Pharmacodynamic antagonistic effects
BM041  Additive hypertensive effects
BM047  Additive thrombogenic effects
BM107  Attenuated pharmacological effects (Unspecific)
  Relation Graph
 Full list of drugs interacting with Darbepoetin alfa
      Pharmacodynamic additive effects
   Additive hypertensive effects Drug Num:  1
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0402
 
Cyclosporine
 
C62H111N11O12
 
5284373 
Moderate    Inter Info   
[1], [3], [14]
   Additive thrombogenic effects Drug Num:  6
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0261
 
Carfilzomib
 
C40H57N5O7
 
11556711 
Major    Inter Info   
[1], [2], [3]
D0902
 
Lenalidomide
 
C13H13N3O3
 
216326 
Major    Inter Info   
[3], [4], [5]
D1312
 
Pomalidomide
 
C13H11N3O4
 
134780 
Major    Inter Info   
[6], [7], [8]
D1569
 
Thalidomide
 
C13H10N2O4
 
5426 
Major    Inter Info   
[3], [6], [9]
D0385
 
Conestat alfa
 
NA
 
NA
Moderate    Inter Info   
[10], [11], [12], [13]
D0762
 
Human C1-esterase inhibitor
 
NA
 
NA
Moderate    Inter Info   
[10], [12], [13]
      Pharmacodynamic antagonistic effects
   Attenuated pharmacological effects (Unspecific) Drug Num:  10
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0156
 
Benazepril
 
C24H28N2O5
 
5362124 
Minor    Inter Info   
[15], [16], [17]
D0254
 
Captopril
 
C9H15NO3S
 
44093 
Minor    Inter Info   
[15], [16], [17]
D0567
 
Enalapril
 
C20H28N2O5
 
5388962 
Minor    Inter Info   
[15], [16], [17]
D0695
 
Fosinopril
 
C30H46NO7P
 
55891 
Minor    Inter Info   
[15], [16], [17]
D0938
 
Lisinopril
 
C21H31N3O5
 
5362119 
Minor    Inter Info   
[15], [16], [17]
D1082
 
Moexipril
 
C27H34N2O7
 
91270 
Minor    Inter Info   
[15], [16], [17]
D1256
 
Perindopril
 
C19H32N2O5
 
107807 
Minor    Inter Info   
[15], [16], [17]
D1369
 
Quinapril
 
C25H30N2O5
 
54892 
Minor    Inter Info   
[15], [16], [17]
D1379
 
Ramipril
 
C23H32N2O5
 
5362129 
Minor    Inter Info   
[15], [16], [17]
D1618
 
Trandolapril
 
C24H34N2O5
 
5484727 
Minor    Inter Info   
[15], [16], [17]
References
1 Cerner Multum, Inc. "Australian Product Information.".
2 Product Information. Kyprolis (carfilzomib). Onyx Pharmaceuticals Inc, South San Francisco, CA.
3 Cerner Multum, Inc. "UK Summary of Product Characteristics.".
4 Product Information. Revlimid (lenalidomide). Celgene Corporation, Summit, NJ.
5 EMEA. European Medicines Agency "EPARs. European Union Public Assessment Reports."
6 Product Information. Fareston (toremifene). Schering Laboratories, Kenilworth, NJ.
7 Product Information. Pomalyst (pomalidomide). QLT Phototherapeutics Inc, Vancouver, AZ.
8 Therapeutic Research Faculty "Natural Medicines Comprehensive Database."
9 Product Information. Thalomid (thalidomide). Celgene Corporation, Warren, NJ.
10 Product Information. Berinert (complement C1 esterase inhibitor). CSL Behring, King of Prussia, PA.
11 Product Information. Cinryze (complement C1 esterase inhibitor). ViroPharma Incorporated, Exton, PA.
12 Product Information. Ruconest (conestat alfa). Valeant Pharmaceuticals, Costa Mesa, CA.
13 Gandhi PK, Gentry WM, Bottorff MB "Thrombotic events associated with C1 esterase inhibitor products in patients with hereditary angioedema: investigation from the United States Food and Drug Administration adverse event reporting system database." Pharmacotherapy 32 (2012): 902-9. [PMID: 23033229]
14 Ducharme MP, Warbasse LH, Edwards DJ "Disposition of intravenous and oral cyclosporine after administration with grapefruit juice." Clin Pharmacol Ther 57 (1995): 485-91. [PMID: 7768070]
15 Ray K, Dorman S, Watson R "Severe hyperkalaemia due to the concomitant use of salt substitutes and ACE inhibitors in hypertension: a potentially life threatening interaction." J Hum Hypertens 13 (1999): 717-20. [PMID: 10516744]
16 Walter J "Does captopril decrease the effect of human recombinant erythropoietin in hemodialysis patients?" Nephrol Dial Transplant 8 (1993): 1428-31
17 Conlon PJ, Albers F, Butterly D, Schwab SJ "ACE inhibitors do not affect erythropoietin efficacy in haemodialysis patients." Nephrol Dial Transplant 9 (1994): 1358