Drug General Information (ID: DDI934QLMY)
Drug Name			Acetylsalicylic acid		Drug Info		Probenecid		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Analgesics				Uricosuric Agents
Structure

Mechanism of Acetylsalicylic acid-Probenecid Interaction (Severity Level: Moderate)
Antagonize the effect of uricosuric agents Click to Show/Hide Mechanism Graph
Drug Name		Acetylsalicylic acid				Probenecid
Mechanism		Anti-uricosuric effects				Uricosuric effects
Key Mechanism Factor 1
		Factor Name		Uricosuric agents
		Factor Description		The beneficial effects of uricosuric agents may be reduced, leading to an increased risk of hyperuricemia and gout.
Mechanism Description		Antagonize the effect of Probenecid when combined with Acetylsalicylic acid

Recommended Action
Management		Large doses of salicylates should be avoided in patients who require probenecid for the treatment of hyperuricemia or gout. However, occasional use of low dosages for analgesia or daily use of cardioprotective dosages should generally not be a concern.

References
1	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
2	Harris M, Bryant LR, Danaher P, Alloway J "Effect of low dose daily aspirin on serum urate levels and urinary excretion in patients receiving probenecid for gouty arthritis." J Rheumatol 27 (2000): 2873-6. [PMID: 11128679]
3	Regal RE "Aspirin and uricosurics: interaction revisited." Drug Intell Clin Pharm 21 (1987): 219-20. [PMID: 3829916]