Drug General Information (ID: DDIK3BJWTX)
Drug Name			Probenecid		Drug Info		Estazolam		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Uricosuric Agents				Anticonvulsants
Structure

Mechanism of Probenecid-Estazolam Interaction (Severity Level: Minor)
Decreased metabolism (Unspecific) Click to Show/Hide Mechanism Graph
Drug Name		Probenecid				Estazolam
Mechanism 1		Interference with hepatic benzodiazepines conjugation				Benzodiazepines
Key Mechanism Factor 1
		Factor Name		Pharmacokinetics
		Factor Description		Alters the metabolism of the drug, leading to changes in the plasma concentration of the drug and affecting the pharmacological effects.
Mechanism Description		Decreased metabolism of Estazolam caused by Probenecid
Mechanism 2		Interference with hepatic benzodiazepines conjugation				Benzodiazepine
Key Mechanism Factor 2
		Factor Name		Pharmacokinetics
		Factor Description		Alters the metabolism of the drug, leading to changes in the plasma concentration of the drug and affecting the pharmacological effects.
Mechanism Description		Decreased metabolism of Estazolam caused by Probenecid

References
1	Abernethy DR, Greenblatt DJ, Ameer B, Shader RI "Probenecid impairment of acetaminophen and lorazepam clearance: direct inhibition of ether glucuronide formation." J Pharmacol Exp Ther 234 (1985): 345-9. [PMID: 4020675]
2	Dundee JW, Halliday NJ, McMurray TJ "Aspirin and probenecid pretreatment influences the potency of thiopentone and the onset of action of midazolam." Eur J Anaesthesiol 3 (1986): 247-51. [PMID: 3780693]