Drug General Information (ID: DDII6VD5X9)
Drug Name			Perindopril		Drug Info		Probenecid		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antihypertensive Agents				Uricosuric Agents
Structure

Mechanism of Perindopril-Probenecid Interaction (Severity Level: Minor)
Competitive inhibition of renal tubular secretion Click to Show/Hide Mechanism Graph
Drug Name		Perindopril				Probenecid
Mechanism		ACE inhibitor				Inhibition of the renal tubular secretion of ACE inhibitor
Key Mechanism Factor 1
		Factor Name		Renal tubular secretion
		Factor Description		Renal tubular secretion allows selective transfer of substances from the blood around the capillaries into the renal tubules via filtrate. Drug excretion may be reduced when two drugs compete for renal tubular secretion.
Mechanism Description		Decreased elimination of Perindopril caused by Probenecid mediated competitive inhibition of renal tubular secretion

References
1	Ray K, Dorman S, Watson R "Severe hyperkalaemia due to the concomitant use of salt substitutes and ACE inhibitors in hypertension: a potentially life threatening interaction." J Hum Hypertens 13 (1999): 717-20. [PMID: 10516744]
2	Singhvi SM, Duchin KL, Willard DA, et al "Renal handling of captopril: effect of probenecid." Clin Pharmacol Ther 32 (1982): 182-9
3	Drummer OH, Thompson J, Hooper R, Jarrott B "Effect of probenecid on the disposition of captopril and captopril dimer in the rat." Biochem Pharmacol 34 (1985): 3347-51