Drug General Information (ID: DDI4AW7LFM)
Drug Name			Ertapenem		Drug Info		Probenecid		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antibiotics				Uricosuric Agents
Structure

Mechanism of Ertapenem-Probenecid Interaction (Severity Level: Minor)
Competitive inhibition of renal tubular secretion Click to Show/Hide Mechanism Graph
Drug Name		Ertapenem				Probenecid
Mechanism		Cephalosporins				Competitive inhibition of renal tubular secretion of some cephalosporins
Key Mechanism Factor 1
		Factor Name		Renal tubular secretion
		Factor Description		Renal tubular secretion allows selective transfer of substances from the blood around the capillaries into the renal tubules via filtrate. Drug excretion may be reduced when two drugs compete for renal tubular secretion.
Mechanism Description		Decreased elimination of Ertapenem caused by Probenecid mediated competitive inhibition of renal tubular secretion

References
1	Product Information. Doribax (doripenem). Ortho McNeil Pharmaceutical, Raritan, NJ.
2	Product Information. Invanz (ertapenem). Merck & Company Inc, West Point, PA.
3	Product Information. Merrem (meropenem). Zeneca Pharmaceuticals, Wilmington, DE.
4	Product Information. Primaxin (imipenem-cilastatin). Merck & Company Inc, West Point, PA.