Drug General Information (ID: DDILHT69C0)
Drug Name			Dapsone		Drug Info		Probenecid		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antiinflammatory Agents				Uricosuric Agents
Structure

Mechanism of Dapsone-Probenecid Interaction (Severity Level: Moderate)
Competitive inhibition of renal tubular secretion Click to Show/Hide Mechanism Graph
Drug Name		Dapsone				Probenecid
Mechanism		Dapsone				Competitive inhibition of renal tubular secretion of dapsone
Key Mechanism Factor 1
		Factor Name		Renal tubular secretion
		Factor Description		Renal tubular secretion allows selective transfer of substances from the blood around the capillaries into the renal tubules via filtrate. Drug excretion may be reduced when two drugs compete for renal tubular secretion.
Mechanism Description		Decreased elimination of Dapsone caused by Probenecid mediated competitive inhibition of renal tubular secretion

Recommended Action
Management		Patients should be monitored for signs of dapsone toxicity, such as nausea, vomiting, hyperexcitability, seizures, muscle weakness, peripheral neuropathy, methemoglobinemia, or blood dyscrasias.

References
1	Goodwin C, Sparell G "Inhibition of dapsone excretion by probenecid." Lancet 2 (1969): 884. [PMID: 4186460]