| Mechanism of Clofibrate-Probenecid Interaction
(Severity Level: Minor)
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Competitive inhibition of renal tubular secretion
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| Drug Name |
Clofibrate |
Probenecid |
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Mechanism
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Clofibrate |
Inhibition of the renal tubular secretion of clofibrate |
| Key Mechanism Factor 1 |
| Factor Name |
Renal tubular secretion |
| Factor Description |
Renal tubular secretion allows selective transfer of substances from the blood around the capillaries into the renal tubules via filtrate. Drug excretion may be reduced when two drugs compete for renal tubular secretion. |
| Mechanism Description |
- Decreased elimination of Clofibrate caused by Probenecid mediated competitive inhibition of renal tubular secretion
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