Details of Drug

Drug General Information (ID: D0360)
Drug Name	Clofibrate
Drug Type	Small molecule
Drug Synonymous	Amotril; Angiokapsul; Anparton; Antilipid; Antilipide; Apolan; Arterioflexin; Arterosol; Artevil; Ateculon; Ateriosan; Athebrate; Atheromide; Atheropront; Athromidin; Atrolen; Atromid; Atromida; Atromidin; Atrovis; Azionyl; Bioscleran; Bresit; CPIB; Cartagyl; Chlorfenisate; Chlorphenisate; Cinnarizin; Citiflus; Claripex; Cloberat; Clobrat; Clofar; Clofibate; Clofibram; Clofibrat; Clofibrato; Clofibratum; Clofinit; Clofipront; Delipid; Deliva; ELPI; EPIB; Fibralem; Gerastop; Hyclorate; Klofibrat; Klofiran; Levatrom; Lipamid; Lipavil; Lipavlon; Lipidsenker; Lipofacton; Lipomid; Liponorm; Liporeduct; Liporil; Liposid; Liprin; Liprinal; Lobetrin; Miscleron; Misclerone; Miskleron; Negalip; Normalip; Normat; Normet; Normolipol; Novofibrate; Persantinat; Recolip; Regardin; Regelan; Robigram; Scrobin; Serofinex; Serotinex; Skerolip; Sklerepmexe; Sklero; Sklerolip; Skleromex; Skleromexe; Ticlobran; Xyduril; Yoclo; Amotril S; Atromid S; Claripex CPIB; Clofibrato [Spanish]; Dura clofibrat; Ethyl chlorophenoxyisobutyrate; Ethyl clofibrate; Regelan N; Vincamin compositum; AY 61123; C 6643; Lipide 500; Oxan 600; AY-61123; Athranid-wirkstoff; Atromid-S; BML2-F02; Chlorophenoxyisobutyrate, Ethyl; Clobren-5F; Clobren-SF; Clofibrate (CLOF); Clofibrato [INN-Spanish]; Clofibratum [INN-Latin]; Clofibric Acid, Ethyl Ester; Ethyl p-chlorophenoxyisobutyrate; Ethyl para-chlorophenoxyisobutyrate; Neo-Atomid; Neo-Atromid; Sklero-Tablinen; Sklero-tablinene; Sklero-tabuls; ATROMID-S (TN); Atromid-S (TN); Atromid-S, Clofibrate; Ethyl alpha-p-chlorophenoxyisobutyrate; Clofibrate (JP15/USP/INN); Clofibrate [USAN:INN:BAN:JAN]; Ethyl 2-(4-chlorophenoxy)isobutyrate; Ethyl 2-(p-chlorophenoxy)isobutyrate; Ethyl alpha-(4-chlorophenoxy)isobutyrate; Ethyl alpha-(p-chlorophenoxy)isobutyrate; Ethyl-alpha-p-chlorophenoxy-isobutyrate Click to Show/Hide
Disease Class	5C80: Hyper-lipoproteinaemia
Therapeutic Class	Antihyperammonia Agents
Structure
Structure	3D Structure		2D Structure
Formula	C12H15ClO3
InChI	1S/C12H15ClO3/c1-4-15-11(14)12(2,3)16-10-7-5-9(13)6-8-10/h5-8H,4H2,1-3H3
InChIKey	KNHUKKLJHYUCFP-UHFFFAOYSA-N
Canonical SMILES	CCOC(=O)C(C)(C)OC1=CC=C(C=C1)Cl
External Link
	Pubchem ID	2796
	CAS Number	637-07-0
	CHEBI ID	3750
	TTD ID	D0J5DC
	INTEDE ID	DR0347

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM003 Affected organization distribution AM004 Affected intra/extra-hepatic metabolism AM005 Affected excretion pathways AM006 Pharmacodynamic additive effects BM013 Competitive binding of plasma proteins BM022 CYP450 enzyme induction BM028 Competitive inhibition of renal tubular secretion BM055 Increased risk of hepatotoxicity BM064 Increased risk of hypoglycemia BM067 Increased risk of hyponatremia BM072 Increased risk of nephrotoxicity BM109 Increased risk of other adverse reactions (Unspecific)
Relation Graph

Full list of drugs interacting with Clofibrate
Affected organization distribution
	Competitive binding of plasma proteins					Drug Num: 6
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1711		Warfarin	C19H16O4	54678486	Major		Inter Info	[4], [5], [6], [7], [8], [9], [10], [11], [12]
D0621		Ethotoin	C11H12N2O2	3292	Minor		Inter Info	[125], [7], [304]
D0697		Fosphenytoin	C16H15N2O6P	56339	Minor		Inter Info	[304]
D0704		Furosemide	C12H11ClN2O5S	3440	Minor		Inter Info	[305], [306], [304]
D1003		Mephenytoin	C12H14N2O2	4060	Minor		Inter Info	[125], [7], [304]
D1283		Phenytoin	C15H12N2O2	1775	Minor		Inter Info	[304]
Affected intra/extra-hepatic metabolism
	CYP450 enzyme induction					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1400		Rifampicin	C43H58N4O12	135398735	Minor		Inter Info	[308]
D1399		Rifabutin	C46H62N4O11	135398743	Minor		Inter Info	[308]
Affected excretion pathways
	Competitive inhibition of renal tubular secretion					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1341		Probenecid	C13H19NO4S	4911	Minor		Inter Info	[307]
Pharmacodynamic additive effects
	Increased risk of hepatotoxicity					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1615		Trabectedin	C39H43N3O11S	108150	Moderate		Inter Info	[7], [123]
	Increased risk of hypoglycemia					Drug Num: 19
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0325		Chlorpropamide	C10H13ClN2O3S	2727	Moderate		Inter Info	[13], [14], [15]
D0728		Glipizide	C21H27N5O4S	3478	Moderate		Inter Info	[16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [13], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [14], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [15], [106], [107], [108], [109], [110], [111], [112], [113]
D0730		Glyburide	C23H28ClN3O5S	3488	Moderate		Inter Info	[16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [13], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [14], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [15], [106], [107], [108], [109], [110], [111], [112], [113]
D0808		Insulin aspart (aspart)	C256H381N65O79S6	118984445	Moderate		Inter Info	[23], [78], [95]
D0809		Insulin degludec	C274H411N65O81S6	118984462	Moderate		Inter Info	[16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [114], [27], [28], [13], [29], [30], [31], [32], [33], [35], [36], [37], [39], [40], [41], [42], [43], [44], [45], [47], [49], [50], [51], [52], [53], [54], [55], [56], [57], [59], [62], [64], [65], [66], [69], [70], [72], [73], [74], [76], [115], [78], [116], [117], [83], [118], [119], [89], [91], [92], [93], [95], [97], [99], [101], [102], [15], [106], [107], [108], [120], [109], [110], [112], [113]
D0810		Insulin detemir	C267H402N64O76S6	16137271	Moderate		Inter Info	[16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [114], [27], [28], [13], [29], [30], [31], [32], [33], [35], [36], [37], [39], [40], [41], [42], [43], [44], [45], [47], [49], [50], [51], [52], [53], [54], [55], [56], [57], [59], [62], [64], [65], [66], [69], [70], [72], [73], [74], [76], [115], [78], [116], [117], [83], [118], [119], [89], [91], [92], [93], [95], [97], [99], [101], [102], [15], [106], [107], [108], [120], [109], [110], [112], [113]
D0812		Insulin glulisine	C258H384N64O78S6	16136701	Moderate		Inter Info	[16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [114], [27], [28], [13], [29], [30], [31], [32], [33], [35], [36], [37], [39], [40], [41], [42], [43], [44], [45], [47], [49], [50], [51], [52], [53], [54], [55], [56], [57], [59], [62], [64], [65], [66], [69], [70], [72], [73], [74], [76], [115], [78], [116], [117], [83], [118], [119], [89], [91], [92], [93], [95], [97], [99], [101], [102], [15], [106], [107], [108], [120], [109], [110], [112], [113]
D1112		Nateglinide	C19H27NO3	5311309	Moderate		Inter Info	[16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [13], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [14], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [15], [106], [107], [108], [109], [110], [111], [112], [113]
D1392		Repaglinide	C27H36N2O4	65981	Moderate		Inter Info	[16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [13], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [14], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [15], [106], [107], [108], [109], [110], [111], [112], [113]
D1601		Tolazamide	C14H21N3O3S	5503	Moderate		Inter Info	[13], [14], [15]
D1603		Tolbutamide	C12H18N2O3S	5505	Moderate		Inter Info	[13], [14], [15]
D0727		Glimepiride	C24H34N4O5S	3476	Moderate		Inter Info	[16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [13], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [14], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [15], [106], [107], [108], [109], [110], [111], [112], [113]
D0811		Insulin glargine	C267H404N72O78S6	118984454	Moderate		Inter Info	[16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [114], [27], [28], [13], [29], [30], [31], [32], [33], [35], [36], [37], [39], [40], [41], [42], [43], [44], [45], [47], [49], [50], [51], [52], [53], [54], [55], [56], [57], [59], [62], [64], [65], [66], [69], [70], [72], [73], [74], [76], [115], [78], [116], [117], [83], [118], [119], [89], [91], [92], [93], [95], [97], [99], [101], [102], [15], [106], [107], [108], [120], [109], [110], [112], [113]
D0814		Insulin human (inhalation, rapid acting)	C257H383N65O77S6	118984375	Moderate		Inter Info	[23], [78], [95]
D0815		Insulin human (isophane)	C257H383N65O77S6	118984375	Moderate		Inter Info	[23], [78], [95]
D0816		Insulin human (regular)	C257H383N65O77S6	118984375	Moderate		Inter Info	[23], [78], [95]
D0817		Insulin human (zinc extended)	C257H383N65O77S6	118984375	Moderate		Inter Info	[23], [78], [95]
D0818		Insulin human (zinc)	C257H383N65O77S6	118984375	Moderate		Inter Info	[23], [78], [95]
D0819		Insulin lispro	C257H389N65O77S6	16132438	Moderate		Inter Info	[16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [114], [27], [28], [13], [29], [30], [31], [32], [33], [35], [36], [37], [39], [40], [41], [42], [43], [44], [45], [47], [49], [50], [51], [52], [53], [54], [55], [56], [57], [59], [62], [64], [65], [66], [69], [70], [72], [73], [74], [76], [115], [78], [116], [117], [83], [118], [119], [89], [91], [92], [93], [95], [97], [99], [101], [102], [15], [106], [107], [108], [120], [109], [110], [112], [113]
	Increased risk of hyponatremia					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0449		Desmopressin	C46H64N14O12S2	5311065	Moderate		Inter Info	[125], [126], [127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [137], [138], [139], [140], [141], [142], [143], [144], [145], [146], [147], [148], [149], [150], [151], [152], [153], [154], [155], [156], [157], [158], [159], [160], [161], [162], [163], [164], [165], [166], [167], [168], [169], [170], [171], [172], [173], [174], [175], [176], [177], [178], [179], [180], [181], [182], [183], [184], [185], [186], [187], [188], [189], [190], [191], [192], [193], [194], [195], [196], [197], [198], [199], [200], [201], [202], [203], [204], [205], [206], [207], [208], [209], [210], [211], [212], [213], [214], [215], [216], [217], [218], [219], [220], [221], [222], [223], [224], [225], [226], [227], [228], [229], [230], [231], [232], [233], [234], [235], [236], [237], [238], [239], [240], [241], [242], [243], [244], [245], [246], [247], [248], [249], [250], [251], [252], [253], [254], [255], [256], [257], [258], [259], [260], [261], [7], [262], [263], [264], [265], [266], [267], [268], [269], [270], [271], [272], [273], [274], [275], [276], [277], [278], [279], [280], [281], [282], [283], [284], [285], [286], [287], [288], [289], [290], [291], [292], [293], [294], [295], [296], [297], [298], [6], [299], [300], [301], [302], [303]
D1683		Vasopressin	C46H65N15O12S2	644077	Moderate		Inter Info	[125], [126], [127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [137], [138], [139], [140], [141], [142], [143], [144], [145], [146], [147], [148], [149], [150], [151], [152], [153], [154], [155], [156], [157], [158], [159], [160], [161], [162], [163], [164], [165], [166], [167], [168], [169], [170], [171], [172], [173], [174], [175], [176], [177], [178], [179], [180], [181], [182], [183], [184], [185], [186], [187], [188], [189], [190], [191], [192], [193], [194], [195], [196], [197], [198], [199], [200], [201], [202], [203], [204], [205], [206], [207], [208], [209], [210], [211], [212], [213], [214], [215], [216], [217], [218], [219], [220], [221], [222], [223], [224], [225], [226], [227], [228], [229], [230], [231], [232], [233], [234], [235], [236], [237], [238], [239], [240], [241], [242], [243], [244], [245], [246], [247], [248], [249], [250], [251], [252], [253], [254], [255], [256], [257], [258], [259], [260], [261], [7], [262], [263], [264], [265], [266], [267], [268], [269], [270], [271], [272], [273], [274], [275], [276], [277], [278], [279], [280], [281], [282], [283], [284], [285], [286], [287], [288], [289], [290], [291], [292], [293], [294], [295], [296], [297], [298], [6], [299], [300], [301], [302], [303]
	Increased risk of nephrotoxicity					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0402		Cyclosporine	C62H111N11O12	5284373	Moderate		Inter Info	[4], [6], [7], [124], [9], [11], [12]
	Increased risk of other adverse reactions (Unspecific)					Drug Num: 9
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0120		Atorvastatin	C33H35FN2O5	60823	Major		Inter Info	[1], [2], [3]
D0686		Fluvastatin	C24H26FNO4	446155	Major		Inter Info	[1], [2], [3]
D1301		Pitavastatin	C25H24FNO4	5282452	Major		Inter Info	[1], [2], [3]
D1430		Rosuvastatin	C22H28FN3O6S	446157	Major		Inter Info	[1], [2], [3]
D1473		Simvastatin	C25H38O5	54454	Major		Inter Info	[1], [2], [3]
D0956		Lovastatin	C24H36O5	53232	Major		Inter Info	[1], [2], [3]
D1329		Pravastatin	C23H36O7	54687	Major		Inter Info	[1], [2], [3]
D1543		Telbivudine	C10H14N2O5	159269	Moderate		Inter Info	[121], [122]
D0421		Daptomycin	C72H101N17O26	16134395	Moderate		Inter Info	[7]

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