Drug General Information (ID: DDITU923BN)
Drug Name			Cyclosporine		Drug Info		Clofibrate		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antiviral Agents				Antihyperammonia Agents
Structure

Mechanism of Cyclosporine-Clofibrate Interaction (Severity Level: Moderate)
Increased risk of nephrotoxicity Click to Show/Hide Mechanism Graph
Drug Name		Cyclosporine				Clofibrate
Mechanism		Cyclosporine				Increase the risk of cyclosporine-induced nephrotoxicity
Key Mechanism Factor 1
		Factor Name		Nephrotoxicity
		Factor Description		The combination of drugs that can induce nephrotoxicity may increase the risk of kidney injury. When kidney injury occurs, the inability to remove excess urine and waste from the body can lead to high levels of urea nitrogen, creatinine, and electrolytes (such as potassium and magnesium) in the blood.
Mechanism Description		Increased risk of nephrotoxicity by the combination of Cyclosporine and Clofibrate

Recommended Action
Management		The manufacturer recommends caution during concomitant administration. Renal function should be closely monitored and the lowest effective dose should be used.

References
1	Adkins JC, Faulds D "Micronised fenofibrate: a review of its pharmacodynamic properties and clinical efficacy in the management of dyslipidaemia." Drugs 54 (1997): 615-33. [PMID: 9339964]
2	Canadian Pharmacists Association.
3	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
4	deLorgeril M, Boissonnat P, Bizollon CA, et al "Pharmacokinetics of cyclosporine in hyperlipidaemic long-term survivors of heart transplantation: lack of interaction with the lipid-lowering agent, fenofibrate." Eur J Clin Pharmacol 43 (1992): 161-5. [PMID: 1425874]
5	Pharmaceutical Society of Australia "APPGuide online. Australian prescription products guide online.".
6	Product Information. Tricor (fenofibrate). Abbott Pharmaceutical, Abbott Park, IL.
7	Product Information. Trilipix (fenofibric acid). Abbott Pharmaceutical, Abbott Park, IL.