Details of Drug Interaction

Details of Drug-Drug Interaction

 Drug General Information (ID: DDIRE1DWCX)
  Drug Name Probenecid Drug Info Imipenem Drug Info
  Drug Type Small molecule Small molecule
  Therapeutic Class Uricosuric Agents Antibiotics
  Structure

 Mechanism of Probenecid-Imipenem Interaction (Severity Level: Minor)
     Competitive inhibition of renal tubular secretion Click to Show/Hide Mechanism Graph
Could Not Find 2D Structure
      Drug Name Probenecid Imipenem
      Mechanism Competitive inhibition of renal tubular secretion of some cephalosporins Cephalosporins
      Key Mechanism Factor 1
Factor Name Renal tubular secretion
Factor Description Renal tubular secretion allows selective transfer of substances from the blood around the capillaries into the renal tubules via filtrate. Drug excretion may be reduced when two drugs compete for renal tubular secretion.
      Mechanism Description
  • Decreased elimination of Imipenem caused by Probenecid mediated competitive inhibition of renal tubular secretion

References
1 Product Information. Doribax (doripenem). Ortho McNeil Pharmaceutical, Raritan, NJ.
2 Product Information. Invanz (ertapenem). Merck &amp Company Inc, West Point, PA.
3 Product Information. Merrem (meropenem). Zeneca Pharmaceuticals, Wilmington, DE.