Details of Drug

Details of Drug

 Drug General Information (ID: D0794)
  Drug Name
Imipenem
  Drug Type Small molecule
  Drug Synonymous
Imipemide; Tienamycin; Imipenem anhydrous; Imipenem (INN); N-Formimidoylthienamycin; Primaxin (TN); Imipenem, N-Formimidoyl thienamycin; [5R-[5.alpha.,6.alpha.(R*)]]-6-(1-Hydroxyethyl)-3-[[2-[(iminomethyl)amino]ethyl]thio]-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid monohydrate; (5R,6S)-3-(2-Formimidoylamino-ethylsulfanyl)-6-((R)-1-hydroxy-ethyl)-7-oxo-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid; (5R,6S)-3-[2-(aminomethylideneamino)ethylsulfanyl]-6-[(1R)-1-hydroxyethyl]-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid; (5R,6S)-6-((R)-1-Hydroxyethyl)-3-(2-(iminomethylamino)ethylthio)-7-oxo-1-azabicyclo(3.2.0)hept-2-ene-2-carbonsaeure; (5R,6S)-6-[(1R)-1-hydroxyethyl]-3-({2-[(iminomethyl)amino]ethyl}thio)-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid
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  Disease Class 1A00-1C4Z: Bacterial infection
  Therapeutic Class Antibiotics
  Structure Could Not Find 2D Structure
3D Structure 2D Structure
  Formula C12H17N3O4S
  InChI 1S/C12H17N3O4S/c1-6(16)9-7-4-8(20-3-2-14-5-13)10(12(18)19)15(7)11(9)17/h5-7,9,16H,2-4H2,1H3,(H2,13,14)(H,18,19)/t6-,7-,9-/m1/s1
  InChIKey ZSKVGTPCRGIANV-ZXFLCMHBSA-N
  Canonical SMILES CC(C1C2CC(=C(N2C1=O)C(=O)O)SCCN=CN)O
  External Link
Pubchem ID 104838
CAS Number 64221-86-9
CHEBI ID 471744
TTD ID D0H3TD
INTEDE ID DR2447

Drug-Drug Interaction Network
  Sunburst Graph
AM001  Affected gastrointestinal absorption
AM005  Affected excretion pathways
AM006  Pharmacodynamic additive effects
AM007  Pharmacodynamic antagonistic effects
BM002  Altered intestinal flora
BM028  Competitive inhibition of renal tubular secretion
BM050  Increased risk of bleeding
BM069  Increased risk of lowers seizure threshold
BM087  Antagonize the effect of antiepileptic agents
BM100  Antagonize the effect of vaccine/toxoid
BM107  Attenuated pharmacological effects (Unspecific)
  Relation Graph
 Full list of drugs interacting with Imipenem
      Affected gastrointestinal absorption
   Altered intestinal flora Drug Num:  2
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D1094
 
Mycophenolate mofetil
 
C23H31NO7
 
5281078 
Moderate    Inter Info   
[37], [38]
D1095
 
Mycophenolic acid
 
C17H20O6
 
446541 
Moderate    Inter Info   
[37], [38]
      Affected excretion pathways
   Competitive inhibition of renal tubular secretion Drug Num:  3
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0576
 
Entecavir
 
C12H15N5O3
 
135398508 
Moderate    Inter Info   
[19]
D1241
 
Pemetrexed
 
C20H21N5O6
 
135410875 
Moderate    Inter Info   
[39]
D1341
 
Probenecid
 
C13H19NO4S
 
4911 
Minor    Inter Info   
[40], [41], [42]
      Pharmacodynamic additive effects
   Increased risk of bleeding Drug Num:  3
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0087
 
Anisindione
 
C16H12O3
 
2197 
Moderate    Inter Info   
[17], [7], [18]
D0481
 
Dicoumarol
 
C19H12O6
 
54676038 
Moderate    Inter Info   
[17], [7], [18]
D1711
 
Warfarin
 
C19H16O4
 
54678486 
Moderate    Inter Info   
[17], [7], [18]
   Increased risk of lowers seizure threshold Drug Num:  11
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0220
 
Bupropion
 
C13H18ClNO
 
444 
Major    Inter Info   
[1], [2], [3]
D0834
 
Iopamidol
 
C17H22I3N3O8
 
65492 
Major    Inter Info   
[4], [5], [6]
D0833
 
Iohexol
 
C19H26I3N3O9
 
3730 
Major    Inter Info   
[4], [5], [6]
D1616
 
Tramadol
 
C16H25NO2
 
33741 
Major    Inter Info   
[11], [12], [13]
D0678
 
Fluphenazine
 
C22H26F3N3OS
 
3372 
Moderate    Inter Info   
[23], [7]
D0710
 
Ganciclovir
 
C9H13N5O4
 
135398740 
Moderate    Inter Info   
[24], [25], [26]
D0722
 
Ginkgo biloba
 
NA
 
NA
Moderate    Inter Info   
[27], [28], [29]
D0054
 
Amifampridine
 
C5H7N3
 
5918 
Moderate    Inter Info   
[30], [31]
D1308
 
Polyethylene glycol (3350 with electrolytes)
 
C2H6O2
 
174 
Moderate    Inter Info   
[32], [33], [7]
D1676
 
Valganciclovir
 
C14H22N6O5
 
135413535 
Moderate    Inter Info   
[24], [25], [26]
D0932
 
Lindane
 
C6H6Cl6
 
727 
Moderate    Inter Info   
[34], [35], [36]
      Pharmacodynamic antagonistic effects
   Antagonize the effect of antiepileptic agents Drug Num:  1
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D1677
 
Valproic acid
 
C8H16O2
 
3121 
Major    Inter Info   
[14], [15], [16]
   Antagonize the effect of vaccine/toxoid Drug Num:  2
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D1914
 
Typhoid vaccine (live)
 
NA
 
NA
Major    Inter Info   
[7], [8], [9]
D1693
 
Vibrio cholerae CVD 103-HgR strain live antigen (live)
 
NA
 
NA
Major    Inter Info   
[10]
   Attenuated pharmacological effects (Unspecific) Drug Num:  2
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0606
 
Estradiol
 
C18H24O2
 
5757 
Moderate    Inter Info   
[20], [21], [22]
D0619
 
Ethinylestradiol
 
C20H24O2
 
5991 
Moderate    Inter Info   
[20], [21], [22]
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24 Product Information. Cytovene (ganciclovir). Genentech, South San Francisco, CA.
25 Product Information. Primaxin (imipenem-cilastatin). Merck &amp Company Inc, West Point, PA.
26 Product Information. Valcyte (valganciclovir) Roche Laboratories, Nutley, NJ.
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38 Product Information. Myfortic (mycophenolic acid). Novartis Pharmaceuticals, East Hanover, NJ.
39 Product Information. Alimta (pemetrexed). Lilly, Eli and Company, Indianapolis, IN.
40 Product Information. Doribax (doripenem). Ortho McNeil Pharmaceutical, Raritan, NJ.
41 Product Information. Invanz (ertapenem). Merck &amp Company Inc, West Point, PA.
42 Product Information. Merrem (meropenem). Zeneca Pharmaceuticals, Wilmington, DE.