Drug General Information (ID: DDI9QNSAE1)
Drug Name			Imipenem		Drug Info		Valganciclovir		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antibiotics				Antiviral Agents
Structure

Mechanism of Imipenem-Valganciclovir Interaction (Severity Level: Moderate)
Increased risk of lowers seizure threshold Click to Show/Hide Mechanism Graph
Drug Name		Imipenem				Valganciclovir
Mechanism		Lower seizure threshold				Lower seizure threshold
Key Mechanism Factor 1
		Factor Name		Lowers seizure threshold
		Factor Description		The combination of medications that lower the seizure threshold is a factor that makes people with epilepsy more likely to have seizures. A seizure is a sudden, uncontrolled electrical disturbance in the brain that can cause changes in your behavior, movements or sensations, and level of consciousness.
Mechanism Description		Increased risk of lowers seizure threshold by the combination of Imipenem and Valganciclovir

Recommended Action
Management		The manufacturers recommend that concomitant use of ganciclovir or its prodrug, valganciclovir, with imipenem-cilastatin be avoided unless the potential benefits outweigh the risks. Patients receiving this combination should be closely monitored for tremors, mental status changes, and seizures.

References
1	Product Information. Cytovene (ganciclovir). Genentech, South San Francisco, CA.
2	Product Information. Primaxin (imipenem-cilastatin). Merck &amp Company Inc, West Point, PA.
3	Product Information. Valcyte (valganciclovir) Roche Laboratories, Nutley, NJ.