Drug General Information (ID: DDIKL4YGN2)
Drug Name			Imipenem		Drug Info		Typhoid vaccine (live)		Drug Info
Drug Type		Small molecule				Vaccine
Therapeutic Class		Antibiotics				Vaccine

Mechanism of Imipenem-Typhoid vaccine (live) Interaction (Severity Level: Major)
Antagonize the effect of vaccine/toxoid Click to Show/Hide Mechanism Graph
Drug Name		Imipenem				Typhoid vaccine (live)
Mechanism		Impairs immunomodulatory bacterial infective agent				Immunomodulatory infective agent
Key Mechanism Factor 1
		Factor Name		Vaccine/toxoid
		Factor Description		The beneficial effects of the vaccine/toxinoid may be reduced, leading to a diminished or suboptimal immune response.
Mechanism Description		Antagonize the effect of Typhoid vaccine (live) when combined with Imipenem

Recommended Action
Management		Live, attenuated oral typhoid vaccine should not be administered during and for at least 3 days before and after treatment with antibacterial sulfonamides or other antibiotics. A longer interval should be considered following treatment with long-acting antibiotics (e.g., azithromycin). If malaria prophylaxis is needed, the same 3-day interval at the minimum should be observed between antimalarials and the vaccine. However, chloroquine, mefloquine, and pyrimethamine-sulfadoxine may be given concomitantly with the vaccine. alternatively, parenteral typhoid vaccine (typhoid Vi polysaccharide vaccine) may be considered if coadministration with antibacterial agents is required.

References
1	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
2	UK government "Typhoid.".
3	American Medical Association, Division of Drugs and Toxicology "Drug evaluations annual 1994." Chicago, IL: American Medical Association (1994).