Drug General Information (ID: DDIZTYVLR5)
Drug Name			Probenecid		Drug Info		Cloxacillin		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Uricosuric Agents				Antibiotics
Structure

Mechanism of Probenecid-Cloxacillin Interaction (Severity Level: Minor)
Competitive inhibition of renal tubular secretion Click to Show/Hide Mechanism Graph
Drug Name		Probenecid				Cloxacillin
Mechanism		Competitive inhibition of renal tubular secretion of penicillins				Penicillins
Key Mechanism Factor 1
		Factor Name		Renal tubular secretion
		Factor Description		Renal tubular secretion allows selective transfer of substances from the blood around the capillaries into the renal tubules via filtrate. Drug excretion may be reduced when two drugs compete for renal tubular secretion.
Mechanism Description		Decreased elimination of Cloxacillin caused by Probenecid mediated competitive inhibition of renal tubular secretion

References
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3	Shanson DC, McNabb R, Hajipieris P "The effect of probenecid on serum amoxycillin concentrations up to 18 hours after a single 3g oral dose of amoxycillin: possible implications for preventing endocarditis." J Antimicrob Chemother 13 (1984): 629-32. [PMID: 6469884]
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5	Sutherland R, Croydon EA, Rolinson GN "Amoxycillin: a new semi-synthetic penicillin." Br Med J 3 (1972): 13-6. [PMID: 4402672]
6	Waller ES, Sharanevych MA, Yakatan GJ "The effect of probenecid on nafcillin disposition." J Clin Pharmacol 22 (1982): 482-9. [PMID: 7174857]