Drug General Information (ID: DDIABSEDP0)
Drug Name			Zidovudine		Drug Info		Probenecid		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Anti-Hiv Agents				Uricosuric Agents
Structure

Mechanism of Zidovudine-Probenecid Interaction (Severity Level: Moderate)
Competitive inhibition of renal tubular secretion Click to Show/Hide Mechanism Graph
Drug Name		Zidovudine				Probenecid
Mechanism		Zidovudine				Inhibition of the renal tubular secretion of zidovudine
Key Mechanism Factor 1
		Factor Name		Renal tubular secretion
		Factor Description		Renal tubular secretion allows selective transfer of substances from the blood around the capillaries into the renal tubules via filtrate. Drug excretion may be reduced when two drugs compete for renal tubular secretion.
Mechanism Description		Decreased elimination of Zidovudine caused by Probenecid mediated competitive inhibition of renal tubular secretion

Recommended Action
Management		Patients should be monitored for signs of zidovudine toxicity (anemia, nausea, headache, myalgia, malaise, fever, or rash). Zidovudine dosage may need to be reduced, or the dosing interval may need to be lengthened.

References
1	Burger DM, Meenhorst PL, Koks CH, Beijnen JH "Drug interactions with zidovudine." AIDS 7 (1993): 445-60. [PMID: 8507410]
2	Kornhauser DM, Hendrix CW, Nerhood LJ, et al "Probenecid and zidovudine metabolism." Lancet 2 (1989): 473-5
3	de Miranda P, Good SS, Yarchoan R, et al "Alteration of zidovudine pharmacokinetics by probenecid in patients with AIDS or AIDS-related complex." Clin Pharmacol Ther 46 (1989): 494-500