Details of Drug

Drug General Information (ID: D1720)
Drug Name	Zidovudine
Drug Type	Small molecule
Drug Synonymous	zidovudine; Azidothymidine; 30516-87-1; 3'-Azido-3'-deoxythymidine; Retrovir; AZT; Zidovudinum; Compound S; Thymidine, 3'-azido-3'-deoxy-; ZIDOVUDINE [AZT]; zidovudin; BW A509U; Zidovudinum [Latin]; Zidovudina [Spanish]; BWA509U; DRG-0004; 3'-Azido-2',3'-Dideoxythymidine; ZDV; UNII-4B9XT59T7S; 3'-Deoxy-3'-azidothymidine; CCRIS 105; Aztec; BW-A509U; BW-A-509U; HSDB 6515; 3'-Azido-3'-deoxythymidine (AIDS); CHEMBL129; NSC 602670; BW-A 509U; MLS000028548; 4B9XT59T7S; AZT; Antiviral; Azidodeoxythymidine; ZVD; Zidovudin; Zidovudina; AZT Antiviral; AZT TRANSPLACENTAL CARCINOGENESIS STUDY; Antiviral AZT; Cpd S; Racemic Liposomal AZT; Zidovudine EP III; BWA 509U; K7 [P Ti2 W10 O40]; AZT & EPO; AZT & HPA; AZT & Lymphoblastoid Interferon; AZT & SST; AZT & rsT4; AZT & sCD4; AZT & srCD4; AZT (Antiviral); AZT+PRO 140; AZT, Antiviral; Apo-Zidovudine; BWA-509U; Intron A & AZT; Novo-Azt; Propolis+AZT; Retrovir (TN); Retrovir(TM); Retrovis (TN); Zidovudine+PRO 140; AZT & Colony-stimulating factor 2; AZT & Concanavalin A (ConA); AZT & GM-CSF; AZT & IFN-alpha; AZT & IL-1; AZT & IL-2; AZT & IL-6; AZT & Li & EPO; AZT & NP (from PHCA or HSA); AZT & PM-19; DS-4152 & AZT; Liposomal AZT-SN-1; Liposomal AZT-SN-3; PC-SOD+AZT;RIFN-beta seron & AZT; AZT & CD4(178)-PE 40; AZT & Li & GM-CSF; AZT & Li & IL-1; AZT & Li & IL-6; AZT & rIFNalpha2; Racemic-dipalmitoylglycerophospho-AZT (in a lipid vesicle); Zidovudine (JAN/USP/INN); Zidovudine [USAN:INN:BAN:JAN]; AZT & rsCD4 & rIFNalphaA; SN-1-dipalmitoylglycerophospho-AZT (in a lipid vesicle); SN-3-dipalmitoylglycerophospho-AZT (in a lipid vesicle); AZT & Interferon-alpha-2; Met-SDF-1beta & AZT; Met-SDF-1beta & Zidovudine; Interferon AD + 3'-azido-3'-deoxythymidine; 1-(3-Azido-2,3-dideoxy-beta-D-ribofuranosyl)thymine; 3′-Azido-3′-deoxythymidine; 3' Azido 2',3' Dideoxythymidine; 3' Azido 3' deoxythymidine; 3'-Azido-3'-deoxythymidine & Concanavalin A; 3'-Azido-3'-deoxythymidine & Erythropoietin; 3'-Azido-3'-deoxythymidine & Heteropolyoxotungstate PM-19; 3'-Azido-3'-deoxythymidine & Interleukin-1; 3'-Azido-3'-deoxythymidine & Interleukin-2; 3'-Azido-3'-deoxythymidine & Interleukin-6; 3'-Azido-3'-deoxythymidine & Lithium & Erythropoietin; 3'-Azido-3'-deoxythymidine & Lithium & Interleukin-1; 3'-Azido-3'-deoxythymidine & Lithium & Interleukin-6; 3'-Azido-3'-deoxythymidine & Lymphoblastoid Interferon; 3'-Azido-3'-deoxythymidine & Sho-Saiko-To; 3'-Azido-3'deoxythymidine & Interferon-alpha; 3'-Azidothymidine; 3'-azido-3'-deoxythymidine, AZT; 3-Azido-3-deoxythymidine; Dendrigen; CTCE-0422 Click to Show/Hide
Disease Class	1C60-1C62: Human immunodeficiency virus disease; 1A24-1D9Z: Virus infection
Therapeutic Class	Anti-Hiv Agents
Structure
Structure	3D Structure		2D Structure
Formula	C10H13N5O4
InChI	1S/C10H13N5O4/c1-5-3-15(10(18)12-9(5)17)8-2-6(13-14-11)7(4-16)19-8/h3,6-8,16H,2,4H2,1H3,(H,12,17,18)/t6-,7+,8+/m0/s1
InChIKey	HBOMLICNUCNMMY-XLPZGREQSA-N
Canonical SMILES	CC1=CN(C(=O)NC1=O)C2CC(C(O2)CO)N=[N+]=[N-]
External Link
	Pubchem ID	35370
	CAS Number	30516-87-1
	CHEBI ID	10110
	TTD ID	D01XYJ
	INTEDE ID	DR1729
	VARIDT ID	DR00296

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM001 Affected gastrointestinal absorption AM002 Affected cellular transport AM004 Affected intra/extra-hepatic metabolism AM005 Affected excretion pathways AM006 Pharmacodynamic additive effects AM007 Pharmacodynamic antagonistic effects BM001 Altered gastrointestinal dynamics BM009 Altered absorption (Unspecific) BM010 Transporter inhibition BM011 Transporter induction BM017 CYP450 enzyme inhibition BM019 UGT inhibition BM022 CYP450 enzyme induction BM023 UGT induction BM024 Competitive inhibition of metabolic enzyme BM025 Decreased metabolism (Unspecific) BM028 Competitive inhibition of renal tubular secretion BM043 Additive immunosuppressive effects BM044 Additive myelosuppressive effects BM055 Increased risk of hepatotoxicity BM072 Increased risk of nephrotoxicity BM107 Attenuated pharmacological effects (Unspecific) BM109 Increased risk of other adverse reactions (Unspecific)
Relation Graph

Full list of drugs interacting with Zidovudine
Affected gastrointestinal absorption
	Altered gastrointestinal dynamics					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0349		Clarithromycin	C38H69NO13	84029	Minor		Inter Info	[112], [113]
	Altered absorption (Unspecific)					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1187		Orlistat	C29H53NO5	3034010	Moderate		Inter Info	[82]
Affected cellular transport
	Transporter inhibition					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1528		Tafamidis	C14H7Cl2NO3	11001318	Moderate		Inter Info	[7], [100], [101]
	Transporter induction					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0095		Apalutamide	C21H15F4N5O2S	24872560	Moderate		Inter Info	[7], [60]
Affected intra/extra-hepatic metabolism
	CYP450 enzyme inhibition					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0375		Cobicistat	C40H53N7O5S2	25151504	Moderate		Inter Info	[15], [7], [63], [64], [65], [66], [67], [68], [69], [70]
	UGT inhibition					Drug Num: 3
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1677		Valproic acid	C8H16O2	3121	Moderate		Inter Info	[56]
D0121		Atovaquone	C22H19ClO3	74989	Minor		Inter Info	[109], [110], [111]
D0619		Ethinylestradiol	C20H24O2	5991	Minor		Inter Info	[58], [49], [59]
	CYP450 enzyme induction					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1399		Rifabutin	C46H62N4O11	135398743	Moderate		Inter Info	[92], [93], [94], [95]
D1401		Rifapentine	C47H64N4O12	135403821	Moderate		Inter Info	[92], [93], [94], [95]
	UGT induction					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0953		Lorlatinib	C21H19FN6O2	71731823	Moderate		Inter Info	[15], [7], [75]
D1415		Ritonavir	C37H48N6O5S2	392622	Minor		Inter Info	[114]
	Competitive inhibition of metabolic enzyme					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1639		Trifluridine	C10H11F3N2O5	6256	Moderate		Inter Info	[7], [32], [29]
	Decreased metabolism (Unspecific)					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0335		Cidofovir	C8H14N3O6P	60613	Moderate		Inter Info	[50]
Affected excretion pathways
	Competitive inhibition of renal tubular secretion					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1241		Pemetrexed	C20H21N5O6	135410875	Moderate		Inter Info	[83]
D1341		Probenecid	C13H19NO4S	4911	Moderate		Inter Info	[20], [84], [85]
Pharmacodynamic additive effects
	Additive immunosuppressive effects					Drug Num: 154
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0023		Adalimumab	NA	NA	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0348		Cladribine	C10H12ClN5O3	20279	Major		Inter Info	[7], [9]
D0802		Infliximab	NA	NA	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D1111		Natalizumab	NA	NA	Major		Inter Info	[14]
D0146		Baricitinib	C16H17N7O2S	44205240	Major		Inter Info	[15], [7], [16]
D0304		Certolizumab pegol	NA	NA	Major		Inter Info	[1], [5], [6]
D0661		Fingolimod	C19H33NO2	107970	Major		Inter Info	[19]
D0736		Golimumab	NA	NA	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D1211		Ozanimod	C23H24N4O3	52938427	Major		Inter Info	[7], [24]
D1474		Siponimod	C29H35F3N2O3	44599207	Major		Inter Info	[15], [26]
D1600		Tofacitinib	C16H20N6O	9926791	Major		Inter Info	[27]
D1666		Upadacitinib	C17H19F3N6O	58557659	Major		Inter Info	[28]
D0030		Aldesleukin	NA	NA	Moderate		Inter Info	[15], [7], [29]
D0032		Alefacept	NA	NA	Moderate		Inter Info	[30], [31], [32]
D0048		Altretamine	C9H18N6	2123	Moderate		Inter Info	[15], [7], [29]
D0085		Anakinra	C20H23N5O7S2	146171046	Moderate		Inter Info	[34], [35], [36]
D0190		Bleomycin	C55H84N17O21S3+	5360373	Moderate		Inter Info	[15], [7], [29]
D0193		Bortezomib	C19H25BN4O4	387447	Moderate		Inter Info	[15], [7], [29]
D0264		Carmustine	C5H9Cl2N3O2	2578	Moderate		Inter Info	[15], [7], [29]
D0312		Chlorambucil	C14H19Cl2NO2	2708	Moderate		Inter Info	[15], [7], [29]
D0313		Chloramphenicol	C11H12Cl2N2O5	5959	Moderate		Inter Info	[15], [7], [49]
D0314		Chloramphenicol (ophthalmic)	C11H12Cl2N2O5	5959	Moderate		Inter Info	[15], [7], [49]
D0419		Dapsone	C12H12N2O2S	2955	Moderate		Inter Info	[15], [7], [29]
D0442		Denileukin diftitox	NA	NA	Moderate		Inter Info	[15], [7], [29]
D0553		Efalizumab	NA	NA	Moderate		Inter Info	[51]
D0666		Floxuridine	C9H11FN2O5	5790	Moderate		Inter Info	[15], [7], [29]
D0714		Gemcitabine	C9H11F2N3O4	60750	Moderate		Inter Info	[15], [7], [29]
D0717		Gemtuzumab ozogamicin	NA	NA	Moderate		Inter Info	[15], [7], [29]
D0784		Ibritumomab tiuxetan	NA	NA	Moderate		Inter Info	[15], [7], [29]
D0902		Lenalidomide	C13H13N3O3	216326	Moderate		Inter Info	[15], [7], [29]
D1077		Mitomycin	C15H18N4O5	5746	Moderate		Inter Info	[15], [7], [29]
D1237		Peginterferon alfa-2a	NA	NA	Moderate		Inter Info	[15], [7], [29]
D1366		Pyrimethamine	C12H13ClN4	4993	Moderate		Inter Info	[7], [53]
D1416		Rituximab	NA	NA	Moderate		Inter Info	[15], [7], [29]
D1508		Streptozocin	C8H15N3O7	29327	Moderate		Inter Info	[15], [7], [29]
D1551		Teniposide	C32H32O13S	452548	Moderate		Inter Info	[15], [7], [29]
D1613		Tositumomab	NA	NA	Moderate		Inter Info	[15], [7], [29]
D1614		Tositumomab (I-131)	NA	NA	Moderate		Inter Info	[15], [7], [29]
D1621		Trastuzumab	NA	NA	Moderate		Inter Info	[15], [7], [29]
D1700		Vinorelbine	C45H54N4O8	5311497	Moderate		Inter Info	[15], [7], [29]
D0006		Abemaciclib	C27H32F2N8	46220502	Moderate		Inter Info	[15], [7], [29]
D0008		Acalabrutinib	C26H23N7O2	71226662	Moderate		Inter Info	[15], [7], [29]
D0027		Aflibercept	NA	NA	Moderate		Inter Info	[15], [7], [29]
D0129		Avapritinib	C26H27FN10	118023034	Moderate		Inter Info	[15], [7], [29]
D0132		Axicabtagene ciloleucel	NA	NA	Moderate		Inter Info	[15], [7], [29]
D0134		Azacitidine	C8H12N4O5	9444	Moderate		Inter Info	[15], [7], [29]
D0136		Azathioprine	C9H7N7O2S	2265	Moderate		Inter Info	[15], [7]
D0150		Belantamab mafodotin	NA	NA	Moderate		Inter Info	[15], [7], [29]
D0153		Belinostat	C15H14N2O4S	6918638	Moderate		Inter Info	[15], [7], [29]
D0157		Bendamustine	C16H21Cl2N3O2	65628	Moderate		Inter Info	[15], [7], [29]
D0191		Blinatumomab	NA	NA	Moderate		Inter Info	[15], [7], [29]
D0195		Bosutinib	C26H29Cl2N5O3	5328940	Moderate		Inter Info	[15], [7], [29]
D0203		Brexucabtagene autoleucel	NA	NA	Moderate		Inter Info	[15], [7], [29]
D0223		Busulfan	C6H14O6S2	2478	Moderate		Inter Info	[15], [7], [29]
D0227		Cabazitaxel	C45H57NO14	9854073	Moderate		Inter Info	[15], [7], [29]
D0246		Canakinumab	NA	NA	Moderate		Inter Info	[34], [35], [36]
D0249		Capecitabine	C15H22FN3O6	60953	Moderate		Inter Info	[15], [7], [29]
D0260		Carboplatin	C6H12N2O4Pt	426756	Moderate		Inter Info	[15], [7], [29]
D0261		Carfilzomib	C40H57N5O7	11556711	Moderate		Inter Info	[15], [7], [29]
D0344		Cisplatin	Cl2H6N2Pt	5702198	Moderate		Inter Info	[15], [7], [29]
D0376		Cobimetinib	C21H21F3IN3O2	16222096	Moderate		Inter Info	[15], [7], [29]
D0389		Copanlisib	C23H28N8O4	135565596	Moderate		Inter Info	[15], [7], [29]
D0400		Cyclophosphamide	C7H15Cl2N2O2P	2907	Moderate		Inter Info	[15], [7], [29]
D0404		Cytarabine	C9H13N3O5	6253	Moderate		Inter Info	[15], [7], [29]
D0407		Dacarbazine	C6H10N6O	135398738	Moderate		Inter Info	[15], [7], [29]
D0410		Dactinomycin	C62H86N12O16	457193	Moderate		Inter Info	[15], [7], [29]
D0422		Daratumumab	NA	NA	Moderate		Inter Info	[15], [7], [29]
D0428		Dasatinib	C22H26ClN7O2S	3062316	Moderate		Inter Info	[15], [7], [29]
D0429		Daunorubicin	C27H29NO10	30323	Moderate		Inter Info	[15], [7], [29]
D0430		Daunorubicin (liposomal)	C27H29NO10	30323	Moderate		Inter Info	[15], [7], [29]
D0443		Denosumab	NA	NA	Moderate		Inter Info	[71]
D0499		Dimethyl fumarate	C6H8O4	637568	Moderate		Inter Info	[72]
D0501		Dinutuximab	NA	NA	Moderate		Inter Info	[15], [7], [29]
D0507		Diroximel fumarate	C11H13NO6	73330464	Moderate		Inter Info	[72]
D0511		Docetaxel	C43H53NO14	148124	Moderate		Inter Info	[15], [7], [29]
D0543		Duvelisib	C22H17ClN6O	50905713	Moderate		Inter Info	[15], [7], [29]
D0560		Elotuzumab	NA	NA	Moderate		Inter Info	[15], [7], [29]
D0594		Eribulin	C40H59NO11	11354606	Moderate		Inter Info	[15], [7], [29]
D0627		Etoposide	C29H32O13	36462	Moderate		Inter Info	[15], [7], [29]
D0629		Everolimus	C53H83NO14	6442177	Moderate		Inter Info	[15], [7], [29]
D0668		Flucytosine	C4H4FN3O	3366	Moderate		Inter Info	[15], [7], [29]
D0669		Fludarabine	C10H12FN5O4	657237	Moderate		Inter Info	[15], [7], [29]
D0675		Fluorouracil	C4H3FN2O2	3385	Moderate		Inter Info	[15], [7], [29]
D0780		Hydroxyurea	CH4N2O2	3657	Moderate		Inter Info	[15], [7], [29]
D0785		Ibrutinib	C25H24N6O2	24821094	Moderate		Inter Info	[15], [7], [29]
D0788		Idarubicin	C26H27NO9	42890	Moderate		Inter Info	[15], [7], [29]
D0806		Inotuzumab ozogamicin	NA	NA	Moderate		Inter Info	[15], [7], [29]
D0829		Iobenguane (I-131)	C8H10IN3	60860	Moderate		Inter Info	[15], [7], [29]
D0845		Irinotecan	C33H38N4O6	60838	Moderate		Inter Info	[15], [7], [29]
D0846		Irinotecan (liposomal)	C33H38N4O6	60838	Moderate		Inter Info	[15], [7], [29]
D0851		Isatuximab	NA	NA	Moderate		Inter Info	[15], [7], [29]
D0873		Ixabepilone	C27H42N2O5S	6445540	Moderate		Inter Info	[15], [7], [29]
D0874		Ixazomib	C14H19BCl2N2O4	25183872	Moderate		Inter Info	[15], [7], [29]
D0910		Levamisole	C11H12N2S	26879	Moderate		Inter Info	[15], [7], [29]
D0933		Linezolid	C16H20FN3O4	441401	Moderate		Inter Info	[15], [7], [29]
D0939		Lisocabtagene maraleucel	NA	NA	Moderate		Inter Info	[15], [7], [29]
D0945		Lomustine	C9H16ClN3O2	3950	Moderate		Inter Info	[15], [7], [29]
D0962		Lurbinectedin	C41H44N4O10S	57327016	Moderate		Inter Info	[15], [7], [29]
D0964		Lutetium Lu 177 dotatate	C65H87LuN14O19S2	76966897	Moderate		Inter Info	[15], [7], [29]
D0986		Mechlorethamine	C5H11Cl2N	4033	Moderate		Inter Info	[15], [7], [29]
D0996		Melphalan	C13H18Cl2N2O2	460612	Moderate		Inter Info	[15], [7], [29]
D1007		Mercaptopurine	C5H4N4S	667490	Moderate		Inter Info	[15], [7], [29]
D1079		Mitoxantrone	C22H28N4O6	4212	Moderate		Inter Info	[15], [7], [29]
D1083		Mogamulizumab	NA	NA	Moderate		Inter Info	[15], [7], [29]
D1085		Monomethyl fumarate	C5H6O4	5369209	Moderate		Inter Info	[72]
D1113		Naxitamab	NA	NA	Moderate		Inter Info	[15], [7], [29]
D1118		Nelarabine	C11H15N5O5	3011155	Moderate		Inter Info	[15], [7], [29]
D1136		Nilotinib	C28H22F3N7O	644241	Moderate		Inter Info	[15], [7], [29]
D1140		Niraparib	C19H20N4O	24958200	Moderate		Inter Info	[78]
D1161		Obinutuzumab	NA	NA	Moderate		Inter Info	[15], [7], [29]
D1162		Ocrelizumab	NA	NA	Moderate		Inter Info	[79]
D1164		Ofatumumab	NA	NA	Moderate		Inter Info	[15], [7], [29]
D1167		Olaparib	C24H23FN4O3	23725625	Moderate		Inter Info	[7], [80]
D1174		Omacetaxine mepesuccinate	C29H39NO9	285033	Moderate		Inter Info	[81]
D1190		Osimertinib	C28H33N7O2	71496458	Moderate		Inter Info	[15], [7], [29]
D1193		Oxaliplatin	C8H14N2O4Pt	9887053	Moderate		Inter Info	[15], [7], [29]
D1212		Paclitaxel	C47H51NO14	36314	Moderate		Inter Info	[15], [7], [29]
D1213		Paclitaxel (protein-bound)	C47H51NO14	36314	Moderate		Inter Info	[15], [7], [29]
D1232		Pazopanib	C21H23N7O2S	10113978	Moderate		Inter Info	[15], [7], [29]
D1250		Pentostatin	C11H16N4O4	439693	Moderate		Inter Info	[15], [7], [29]
D1306		Polatuzumab vedotin	NA	NA	Moderate		Inter Info	[15], [7], [29]
D1312		Pomalidomide	C13H11N3O4	134780	Moderate		Inter Info	[15], [7], [29]
D1313		Ponatinib	C29H27F3N6O	24826799	Moderate		Inter Info	[15], [7], [29]
D1323		Pralatrexate	C23H23N7O5	148121	Moderate		Inter Info	[15], [7], [29]
D1345		Procarbazine	C12H19N3O	4915	Moderate		Inter Info	[15], [7], [29]
D1375		Radium Ra 223 dichloride	NA	NA	Moderate		Inter Info	[86]
D1398		Ribociclib	C23H30N8O	44631912	Moderate		Inter Info	[15], [7], [29]
D1422		Roflumilast	C17H14Cl2F2N2O3	449193	Moderate		Inter Info	[7], [96]
D1424		Romidepsin	C24H36N4O6S2	5352062	Moderate		Inter Info	[15], [7], [29]
D1432		Rucaparib	C19H18FN3O	9931954	Moderate		Inter Info	[15], [7], [29]
D1434		Ruxolitinib	C17H18N6	25126798	Moderate		Inter Info	[15], [7], [29]
D1447		Sarilumab	NA	NA	Moderate		Inter Info	[15], [7], [29]
D1458		Selinexor	C17H11F6N7O	71481097	Moderate		Inter Info	[15], [7], [29]
D1476		Sirolimus	C51H79NO13	5284616	Moderate		Inter Info	[15], [7], [29]
D1487		Sodium phosphate, monobasic (p32)	NA	NA	Moderate		Inter Info	[97]
D1509		Strontium chloride Sr-89	Cl2Sr	5388879	Moderate		Inter Info	[15], [7], [53]
D1526		Tacrolimus	C44H69NO12	445643	Moderate		Inter Info	[15], [7], [29]
D1529		Tafasitamab	NA	NA	Moderate		Inter Info	[15], [7], [29]
D1532		Talazoparib	C19H14F2N6O	135565082	Moderate		Inter Info	[15], [7], [29]
D1549		Temsirolimus	C56H87NO16	6918289	Moderate		Inter Info	[15], [7], [29]
D1569		Thalidomide	C13H10N2O4	5426	Moderate		Inter Info	[15], [7], [29]
D1575		Thiotepa	C6H12N3PS	5453	Moderate		Inter Info	[15], [7], [29]
D1594		Tisagenlecleucel	NA	NA	Moderate		Inter Info	[15], [7], [29]
D1599		Tocilizumab	NA	NA	Moderate		Inter Info	[15], [7], [29]
D1610		Topotecan	C23H23N3O5	60700	Moderate		Inter Info	[15], [7], [29]
D1622		Trastuzumab deruxtecan	NA	NA	Moderate		Inter Info	[15], [7], [29]
D1646		Trimetrexate	C19H23N5O3	5583	Moderate		Inter Info	[15], [7], [29]
D1667		Uracil mustard	C8H11Cl2N3O2	6194	Moderate		Inter Info	[15], [7], [29]
D1671		Ustekinumab	NA	NA	Moderate		Inter Info	[103]
D1688		Venetoclax	C45H50ClN7O7S	49846579	Moderate		Inter Info	[15], [7], [29]
D1697		Vinblastine	C46H58N4O9	13342	Moderate		Inter Info	[15], [7], [29]
D1698		Vincristine	C46H56N4O10	5978	Moderate		Inter Info	[15], [7], [29]
D1699		Vincristine (liposome)	C46H56N4O10	5978	Moderate		Inter Info	[15], [7], [29]
D1718		Zanubrutinib	C27H29N5O3	135565884	Moderate		Inter Info	[15], [7], [29]
	Additive myelosuppressive effects					Drug Num: 18
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0370		Clozapine	C18H19ClN4	135398737	Major		Inter Info	[7], [10], [11]
D0821		Interferon alfa-2a, Recombinant	NA	NA	Major		Inter Info	[7], [12], [13]
D0822		Interferon alfa-2b	C16H17Cl3I2N3NaO5S	71306834	Major		Inter Info	[7], [12], [13]
D0824		Interferon alfa-n1	NA	NA	Major		Inter Info	[7], [12], [13]
D0825		Interferon alfa-n3	NA	NA	Major		Inter Info	[7], [12], [13]
D0823		Interferon alfacon-1	NA	NA	Major		Inter Info	[7], [12], [13]
D0826		Interferon beta-1a	NA	NA	Major		Inter Info	[7], [12], [13]
D0827		Interferon beta-1b	NA	NA	Major		Inter Info	[7], [12], [13]
D0828		Interferon gamma-1b	NA	NA	Major		Inter Info	[7], [12], [13]
D1238		Peginterferon alfa-2b	NA	NA	Major		Inter Info	[7], [12], [13]
D0433		Deferiprone	C7H9NO2	2972	Major		Inter Info	[15], [17], [18]
D0710		Ganciclovir	C9H13N5O4	135398740	Major		Inter Info	[20], [15], [11]
D1239		Peginterferon beta-1a	NA	NA	Major		Inter Info	[7], [12], [13]
D1676		Valganciclovir	C14H22N6O5	135413535	Major		Inter Info	[20], [15], [11]
D0033		Alemtuzumab	NA	NA	Moderate		Inter Info	[33]
D0075		Amphotericin B	C47H73NO17	5280965	Moderate		Inter Info	[57]
D0076		Amphotericin B (cholesteryl sulfate)	C47H73NO17	5280965	Moderate		Inter Info	[58], [57], [59]
D0077		Amphotericin B (lipid complex)	C47H73NO17	5280965	Moderate		Inter Info	[58], [57], [59]
	Increased risk of hepatotoxicity					Drug Num: 20
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0900		Leflunomide	C12H9F3N2O2	3899	Major		Inter Info	[21]
D0944		Lomitapide	C39H37F6N3O2	9853053	Major		Inter Info	[22]
D1073		Mipomersen	C230H324N67O122P19S19	118984467	Major		Inter Info	[23]
D1258		Pexidartinib	C20H15ClF3N5	25151352	Major		Inter Info	[25]
D1556		Teriflunomide	C12H9F3N2O2	54684141	Major		Inter Info	[21]
D0114		Asparaginase Escherichia coli	NA	NA	Moderate		Inter Info	[37], [38], [39], [15], [7], [40], [41], [42], [43], [44], [45], [46], [47]
D0584		Epirubicin	C27H29NO11	41867	Moderate		Inter Info	[15], [7], [52]
D1234		Pegaspargase	C14H19NO	436058	Moderate		Inter Info	[37], [38], [39], [15], [7], [40], [41], [42], [43], [44], [45], [46], [47]
D1589		Tioguanine	C5H5N5S	2723601	Moderate		Inter Info	[54], [55]
D0113		Asparaginase Erwinia chrysanthemi	NA	NA	Moderate		Inter Info	[37], [38], [39], [15], [7], [40], [41], [42], [43], [44], [45], [46], [47]
D0149		Bedaquiline	C32H31BrN2O2	5388906	Moderate		Inter Info	[61]
D0199		Brentuximab vedotin	NA	NA	Moderate		Inter Info	[62]
D0232		Calaspargase pegol	NA	NA	Moderate		Inter Info	[37], [38], [39], [15], [7], [40], [41], [42], [43], [44], [45], [46], [47]
D0554		Efavirenz	C14H9ClF3NO2	64139	Moderate		Inter Info	[73], [68]
D0789		Idelalisib	C22H18FN7O	11625818	Moderate		Inter Info	[74]
D1025		Methotrexate	C20H22N8O5	126941	Moderate		Inter Info	[7], [76]
D1106		Naltrexone	C20H23NO4	5360515	Moderate		Inter Info	[77]
D1389		Remdesivir	C27H35N6O8P	121304016	Moderate		Inter Info	[15], [7], [87], [88], [89]
D1615		Trabectedin	C39H43N3O11S	108150	Moderate		Inter Info	[7], [102]
D0011		Acetaminophen	C8H9NO2	1983	Minor		Inter Info	[104], [20], [105], [106], [107], [108]
	Increased risk of nephrotoxicity					Drug Num: 3
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0292		Ceftazidime	C22H22N6O7S2	5481173	Moderate		Inter Info	[15], [7]
D1246		Pentamidine	C19H24N4O2	4735	Moderate		Inter Info	[15], [7]
D1304		Plazomicin	C25H48N6O10	42613186	Moderate		Inter Info	[15], [7]
	Increased risk of other adverse reactions (Unspecific)					Drug Num: 24
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0178		Bexarotene	C24H28O2	82146	Major		Inter Info	[7], [8]
D0172		Betamethasone	C22H29FO5	9782	Moderate		Inter Info	[29], [48]
D0956		Lovastatin	C24H36O5	53232	Moderate		Inter Info	[29], [48]
D1329		Pravastatin	C23H36O7	54687	Moderate		Inter Info	[29], [48]
D0120		Atorvastatin	C33H35FN2O5	60823	Moderate		Inter Info	[29], [48]
D0215		Budesonide	C25H34O6	5281004	Moderate		Inter Info	[29], [48]
D0320		Chloroquine	C18H26ClN3	2719	Moderate		Inter Info	[29], [48]
D0453		Dexamethasone	C22H29FO5	5743	Moderate		Inter Info	[29], [48]
D0642		Fenofibrate	C20H21ClO4	3339	Moderate		Inter Info	[29], [48]
D0643		Fenofibric acid	C17H15ClO4	64929	Moderate		Inter Info	[29], [48]
D0686		Fluvastatin	C24H26FNO4	446155	Moderate		Inter Info	[29], [48]
D0715		Gemfibrozil	C15H22O3	3463	Moderate		Inter Info	[29], [48]
D0773		Hydrocortisone	C21H30O5	5754	Moderate		Inter Info	[29], [48]
D0779		Hydroxychloroquine	C18H26ClN3O	3652	Moderate		Inter Info	[29], [48]
D1041		Methylprednisolone	C22H30O5	6741	Moderate		Inter Info	[29], [48]
D1129		Niacin	C6H5NO2	938	Moderate		Inter Info	[29], [48]
D1245		Penicillamine	C5H11NO2S	5852	Moderate		Inter Info	[29], [48]
D1301		Pitavastatin	C25H24FNO4	5282452	Moderate		Inter Info	[29], [48]
D1332		Prednisolone	C21H28O5	5755	Moderate		Inter Info	[29], [48]
D1334		Prednisone	C21H26O5	5865	Moderate		Inter Info	[29], [48]
D1430		Rosuvastatin	C22H28FN3O6S	446157	Moderate		Inter Info	[29], [48]
D1473		Simvastatin	C25H38O5	54454	Moderate		Inter Info	[29], [48]
D1543		Telbivudine	C10H14N2O5	159269	Moderate		Inter Info	[29], [48]
D1628		Triamcinolone	C21H27FO6	31307	Moderate		Inter Info	[29], [48]
Pharmacodynamic antagonistic effects
	Attenuated pharmacological effects (Unspecific)					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1397		Ribavirin	C8H12N4O5	37542	Moderate		Inter Info	[7], [90], [91]
D1504		Stavudine	C10H12N2O4	18283	Moderate		Inter Info	[29], [98], [99]

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