Drug General Information (ID: DDI3ZVOM0B)
Drug Name			Zidovudine		Drug Info		Penicillamine		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Anti-Hiv Agents				Antidotes
Structure

Mechanism of Zidovudine-Penicillamine Interaction (Severity Level: Moderate)
Increased risk of other adverse reactions (Unspecific) Click to Show/Hide Mechanism Graph
Drug Name		Zidovudine				Penicillamine
Mechanism		Rhabdomyolysis				Rhabdomyolysis
Key Mechanism Factor 1
		Factor Name		Adverse reactions
		Factor Description		An adverse reaction is an unexpected negative reaction to a medication or treatment that happens even when it's used correctly.
Mechanism Description		Increased risk of adverse reactions by the combination of Zidovudine and Penicillamine

Recommended Action
Management		Clinicians should carefully consider the benefits versus risks prior to prescribing these agents together. Patients should be advised to promptly report any unexplained muscle pain, tenderness, or weakness, particularly if accompanied by malaise or fever.

References
1	Product Information. Retrovir (zidovudine). Glaxo Wellcome, Research Triangle Park, NC.
2	Product Information. Tyzeka (telbivudine). IDEC Pharmaceuticals Corporation, San Diego, CA.