Details of Drug

Drug General Information (ID: D1245)
Drug Name	Penicillamine
Drug Type	Small molecule
Drug Synonymous	D-Penicillamine; penicillamine; 52-67-5; Cuprimine; D-(-)-Penicillamine; 3-Mercapto-D-valine; Depen; Cuprenil; D-Penamine; (-)-Penicillamine; (2S)-2-Amino-3-methyl-3-sulfanylbutanoic acid; D-Mercaptovaline; Mercaptovaline; Perdolat; Penicillamin; Pendramine; Kuprenil; Depamine; Mercaptyl; Trolovol; Metalcaptase; Artamine; Cupripen; (S)-3,3-Dimethylcysteine; D-Valine, 3-mercapto-; Penicillaminum; Penicilamina; Sufirtan; beta-Thiovaline; Dimethylcysteine; D-beta,beta-Dimethylcysteine; D-3-Mercaptovaline; beta,beta-Dimethylcysteine; Penicillamina; Penicilllamine; Sufortan; Copper penicillaminate; D Penicillamine; Penicillamina [DCIT]; Reduced penicillamine; D 3 Mercaptovaline; TBB068824; Beta,beta Dimethylcysteine; Beta-Thiovaline; Cuprimine (TN); D-Penicilamine; D-Penicyllamine; Depen (TN); P-1280; Penicilamina [INN-Spanish]; Penicillaminate, Copper; Penicillaminum [INN-Latin]; Reduced D-penicillamine; Beta,beta-Dimethylcysteine; D,3-Mercaptovaline; D-beta-Mercaptovaline; Distamine (Hydrochloride); Metalcaptase (Hydrochloride); Penicillamine (JAN/USP/INN); Penicillamine [USAN:INN:BAN:JAN]; Alpha-Amino-beta-methyl-beta-mercaptobutyric acid; D-(-)-2-Amino-3-mercapto-3-methylbutanoic acid; (2S)-2-amino-3-methyl-3-sulfanyl-butanoic acid; (D)-PENICILLAMINE; (S)-Penicillamin; (S)-Penicillamine; 2-Amino-3-mercapto-3-methylbutanoic acid; 3,3-Dimethyl-D-cysteine; 3-Mercaptovaline; 3-sulfanyl-D-valine; D-penicillamine Click to Show/Hide
Disease Class	FA20: Rheumatoid arthritis
Therapeutic Class	Antidotes
Structure
Structure	3D Structure		2D Structure
Formula	C5H11NO2S
InChI	1S/C5H11NO2S/c1-5(2,9)3(6)4(7)8/h3,9H,6H2,1-2H3,(H,7,8)/t3-/m0/s1
InChIKey	VVNCNSJFMMFHPL-VKHMYHEASA-N
Canonical SMILES	CC(C)(C(C(=O)O)N)S
External Link
	Pubchem ID	5852
	CAS Number	771431-20-0
	CHEBI ID	7959
	TTD ID	D08HZC

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM001 Affected gastrointestinal absorption AM005 Affected excretion pathways AM006 Pharmacodynamic additive effects BM003 Complex formation BM027 Decreased renal excretion due to nephrotoxicity BM032 Decreased renal excretion (Unspecific) BM043 Additive immunosuppressive effects BM044 Additive myelosuppressive effects BM072 Increased risk of nephrotoxicity BM109 Increased risk of other adverse reactions (Unspecific)
Relation Graph

Full list of drugs interacting with Penicillamine
Affected gastrointestinal absorption
	Complex formation					Drug Num: 36
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0235		Calcium acetate	C4H6CaO4	6116	Moderate		Inter Info	[20], [21], [22], [23], [24], [25], [26], [27]
D0975		Magnesium sulfate	MgO4S	24083	Moderate		Inter Info	[20], [21], [22], [23], [24], [25], [26], [27]
D0049		Aluminum hydroxide	AlH3O3	10176082	Moderate		Inter Info	[20], [21], [22], [23], [24], [25], [26], [27]
D0125		Attapulgite	Al2H29Mg2O15Si4-	56842194	Moderate		Inter Info	[20], [21], [22], [23], [24], [25], [26], [27]
D0236		Calcium carbonate	CCaO3	10112	Moderate		Inter Info	[20], [21], [22], [23], [24], [25], [26], [27]
D0238		Calcium citrate	C12H10Ca3O14	13136	Moderate		Inter Info	[20], [21], [22], [23], [24], [25], [26], [27]
D0239		Calcium glubionate anhydrous	C18H32CaO19	64776	Moderate		Inter Info	[23], [24], [28]
D0241		Calcium gluconate	C12H22CaO14	9290	Moderate		Inter Info	[20], [21], [22], [23], [24], [25], [26], [27]
D0242		Calcium glycerophosphate	C3H7CaO6P	120096	Moderate		Inter Info	[20], [21], [22], [23], [24], [25], [26], [27]
D0243		Calcium lactate	C6H10CaO6	13144	Moderate		Inter Info	[20], [21], [22], [23], [24], [25], [26], [27]
D0244		Calcium Phosphate	Ca3O8P2	24456	Moderate		Inter Info	[23], [24], [28]
D0332		Chromium picolinate	C18H12CrN3O6	151932	Moderate		Inter Info	[20], [21], [22], [23], [24], [25], [26], [27]
D0390		Copper gluconate	C12H22CuO14	10692	Moderate		Inter Info	[20], [21], [22], [23], [24], [25], [26], [27]
D0483		Didanosine	C10H12N4O3	135398739	Moderate		Inter Info	[20], [21], [22], [23], [24], [25], [26], [27]
D0649		Ferrous fumarate	C4H2FeO4	6433164	Moderate		Inter Info	[20], [21], [22], [23], [24], [25], [26], [27]
D0650		Ferrous gluconate	C12H22FeO14	23616740	Moderate		Inter Info	[20], [21], [22], [23], [24], [25], [26], [27]
D0651		Ferrous sulfate anhydrous	FeO4S	24393	Moderate		Inter Info	[23], [24], [28]
D0847		Iron	Fe	23925	Moderate		Inter Info	[23], [24], [28]
D0849		Iron protein succinylate	NA	NA	Moderate		Inter Info	[20], [21], [22], [23], [24], [25], [26], [27]
D0877		Kaolin	Al2H4O9Si2	56841936	Moderate		Inter Info	[20], [21], [22], [23], [24], [25], [26], [27]
D0893		Lanthanum carbonate	C3La2O9	168924	Moderate		Inter Info	[36], [13], [2], [37], [38], [39]
D0967		Magaldrate	AlHMgO5S+2	3086011	Moderate		Inter Info	[20], [21], [22], [23], [24], [25], [26], [27]
D0968		Magnesium carbonate	CMgO3	11029	Moderate		Inter Info	[20], [21], [22], [23], [24], [25], [26], [27]
D0969		Magnesium chloride	Cl2H12MgO6	643991	Moderate		Inter Info	[20], [21], [22], [23], [24], [25], [26], [27]
D0970		Magnesium citrate	C12H10Mg3O14	6099959	Moderate		Inter Info	[20], [21], [22], [23], [24], [25], [26], [27]
D0971		Magnesium gluconate	C12H22MgO14	11418570	Moderate		Inter Info	[20], [21], [22], [23], [24], [25], [26], [27]
D0972		Magnesium glycinate	C4H8MgN2O4	84645	Moderate		Inter Info	[20], [21], [22], [23], [24], [25], [26], [27]
D0973		Magnesium hydroxide	H2MgO2	14791	Moderate		Inter Info	[20], [21], [22], [23], [24], [25], [26], [27]
D0974		Magnesium oxide	MgO	14792	Moderate		Inter Info	[20], [21], [22], [23], [24], [25], [26], [27]
D1369		Quinapril	C25H30N2O5	54892	Moderate		Inter Info	[2], [43]
D1456		Selenium	Se	6326970	Moderate		Inter Info	[20], [21], [22], [23], [24], [25], [26], [27]
D1566		Tetraferric tricitrate decahydrate	C18H32Fe4O31	90478690	Moderate		Inter Info	[23], [24], [28]
D1722		Zinc acetate	C4H6O4Zn	11192	Moderate		Inter Info	[51], [52], [53], [54], [55]
D1724		Zinc gluconate	C12H22O14Zn	443445	Moderate		Inter Info	[51], [52], [53], [54], [55]
D1725		Zinc sulfate	O4SZn	24424	Moderate		Inter Info	[51], [52], [53], [54], [55]
D1511		Sucralfate	C12H54Al9O55S8	121494085	Moderate		Inter Info	[20], [21], [22], [23], [24], [25], [26], [27]
Affected excretion pathways
	Decreased renal excretion due to nephrotoxicity					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1389		Remdesivir	C27H35N6O8P	121304016	Moderate		Inter Info	[13], [2], [45], [46], [47]
	Decreased renal excretion (Unspecific)					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1341		Probenecid	C13H19NO4S	4911	Moderate		Inter Info	[42]
Pharmacodynamic additive effects
	Additive immunosuppressive effects					Drug Num: 10
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0900		Leflunomide	C12H9F3N2O2	3899	Major		Inter Info	[2], [17]
D1556		Teriflunomide	C12H9F3N2O2	54684141	Major		Inter Info	[17], [18]
D0320		Chloroquine	C18H26ClN3	2719	Moderate		Inter Info	[20], [28], [29]
D0126		Auranofin	C20H34AuO9PS	24199313	Moderate		Inter Info	[31], [32], [33]
D0127		Aurothioglucose	C6H11AuO5S	454937	Moderate		Inter Info	[31], [32], [33]
D0779		Hydroxychloroquine	C18H26ClN3O	3652	Moderate		Inter Info	[20], [28], [29]
D1162		Ocrelizumab	NA	NA	Moderate		Inter Info	[40]
D1375		Radium Ra 223 dichloride	NA	NA	Moderate		Inter Info	[44]
D1479		Sodium aurothiomalate	C4H3AuNa2O4S	22318	Moderate		Inter Info	[31], [32], [33]
D1671		Ustekinumab	NA	NA	Moderate		Inter Info	[50]
	Additive myelosuppressive effects					Drug Num: 8
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0348		Cladribine	C10H12ClN5O3	20279	Major		Inter Info	[2], [3]
D0370		Clozapine	C18H19ClN4	135398737	Major		Inter Info	[2], [4], [5]
D0433		Deferiprone	C7H9NO2	2972	Major		Inter Info	[13], [14], [15]
D0033		Alemtuzumab	NA	NA	Moderate		Inter Info	[19]
D0136		Azathioprine	C9H7N7O2S	2265	Moderate		Inter Info	[13], [2]
D0710		Ganciclovir	C9H13N5O4	135398740	Moderate		Inter Info	[13], [2], [34], [35]
D1174		Omacetaxine mepesuccinate	C29H39NO9	285033	Moderate		Inter Info	[41]
D1676		Valganciclovir	C14H22N6O5	135413535	Moderate		Inter Info	[13], [2], [34], [35]
	Increased risk of nephrotoxicity					Drug Num: 12
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0335		Cidofovir	C8H14N3O6P	60613	Major		Inter Info	[1]
D0472		Diatrizoate	C11H9I3N2O4	2140	Major		Inter Info	[6], [7], [8], [9], [10], [11], [12]
D0805		Inotersen	C230H318N69O121P19S19	121492004	Major		Inter Info	[2], [16]
D0831		Iodipamide	C20H14I6N2O6	3739	Major		Inter Info	[6], [7], [8], [9], [10], [11], [12]
D0832		Iodixanol	C35H44I6N6O15	3724	Major		Inter Info	[6], [7], [8], [9], [10], [11], [12]
D0833		Iohexol	C19H26I3N3O9	3730	Major		Inter Info	[6], [7], [8], [9], [10], [11], [12]
D0834		Iopamidol	C17H22I3N3O8	65492	Major		Inter Info	[6], [7], [8], [9], [10], [11], [12]
D0836		Iopromide	C18H24I3N3O8	3736	Major		Inter Info	[6], [7], [8], [9], [10], [11], [12]
D0837		Iothalamic acid	C11H9I3N2O4	3737	Major		Inter Info	[8], [9], [10]
D0838		Ioversol	C18H24I3N3O9	3741	Major		Inter Info	[6], [7], [8], [9], [10], [11], [12]
D0839		Ioxilan	C18H24I3N3O8	3743	Major		Inter Info	[6], [7], [8], [9], [10], [11], [12]
D0357		Clofarabine	C10H11ClFN5O3	119182	Moderate		Inter Info	[30]
	Increased risk of other adverse reactions (Unspecific)					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1543		Telbivudine	C10H14N2O5	159269	Moderate		Inter Info	[48], [49]
D1720		Zidovudine	C10H13N5O4	35370	Moderate		Inter Info	[48], [49]

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