Details of Drug Interaction

Details of Drug-Drug Interaction

 Drug General Information (ID: DDIQGY169P)
  Drug Name Acetaminophen Drug Info Zidovudine Drug Info
  Drug Type Small molecule Small molecule
  Therapeutic Class Analgesics Anti-Hiv Agents
  Structure

 Mechanism of Acetaminophen-Zidovudine Interaction (Severity Level: Minor)
     Additive myelosuppressive effects Click to Show/Hide Mechanism Graph
Could Not Find 2D Structure
      Drug Name Acetaminophen Zidovudine
      Mechanism 1 Myelosuppressive effects Myelosuppressive effects
      Key Mechanism Factor 1
Factor Name Myelosuppressive effects
Factor Description Myelosuppression, also known as bone marrow suppression, is a decrease in bone marrow activity that leads to a decrease in the production of blood cells. Some blood cell disorders include: erythrocytopenia (anemia), leukopenia (neutropenia), and thrombocytopenia (thrombocytopenia).
      Mechanism Description
  • Additive myelosuppressive effects by the combination of Acetaminophen and Zidovudine 
     Increased risk of hepatotoxicity Click to Show/Hide Mechanism Graph
Could Not Find 2D Structure
      Drug Name Acetaminophen Zidovudine
      Mechanism 2 Hepatotoxicity Hepatotoxicity
      Key Mechanism Factor 2
Factor Name Hepatotoxicity
Factor Description Combination of drugs that can induce hepatotoxicity may increase the risk of liver injury. Symptoms vary depending on the level of exposure and the total extent of liver damage, and may cause few symptoms if the damage is mild, and eventually lead to liver failure in patients with severe damage.
      Mechanism Description
  • Increased risk of hepatotoxicity by the combination of Acetaminophen and Zidovudine 

References
1 Ameer B "Acetaminophen hepatotoxicity augmented by zidovudine." Am J Med 95 (1993): 342. [PMID: 8368234]
2 Burger DM, Meenhorst PL, Koks CH, Beijnen JH "Drug interactions with zidovudine." AIDS 7 (1993): 445-60. [PMID: 8507410]
3 Gill PS, Rarick M, Brynes RK, et al "Azidothymidine associated with bone marrow failure in the acquired immunodeficiency syndrome (AIDS)." Ann Intern Med 107 (1987): 502-5. [PMID: 3477107]
4 Goldsmith JC, Irvine W "Reversible agranulocytosis related to azidothymidine therapy." Am J Hematol 30 (1989): 263-4. [PMID: 2929589]
5 Sattler FR, Ko R, Antoniskis D, et al "Acetaminophen does not impair clearance of zidovudine." Ann Intern Med 114 (1991): 937-40. [PMID: 3515928]
6 Shriner K, Goetz MB "Severe hepatoxicity in a patient receiving both acetaminophen and zidovudine." Am J Med 93 (1992): 94-6. [PMID: 1626578]