Details of Drug

Drug General Information (ID: D0011)
Drug Name	Acetaminophen
Drug Type	Small molecule
Drug Synonymous	acetaminophen; 4-Acetamidophenol; Paracetamol; 103-90-2; Tylenol; N-(4-Hydroxyphenyl)acetamide; APAP; Acetaminofen; Panadol; Datril; p-Hydroxyacetanilide; N-Acetyl-p-aminophenol; p-Acetamidophenol; Algotropyl; Naprinol; Lonarid; 4'-Hydroxyacetanilide; Multin; Acenol; Acamol; Anelix; p-Acetaminophenol; Liquagesic; Acetagesic; Gelocatil; Servigesic; Acetalgin; Abensanil; Pyrinazine; Injectapap; Clixodyne; Valgesic; Tussapap; Finimal; Paracet; Homoolan; Febrolin; Febrilix; Febridol; Dymadon; Anaflon; Apamide; Valadol; Tralgon; Tabalgin; Lestemp; Alvedon; Abenol; Abrol; Abrolet; Acephen; Acertol; Acetaco; Acetamol; Acetavance; Acetofen; Actamin; Actimol; Afebrin; Afebryl; Aferadol; Algesidal; Algina; Algomol; Alpiny; Alpinyl; Amadil; Aminofen; Analter; Anapap; Andox; Anhiba; Antidol; Anuphen; Apacet; Apadon; Apitrelal; Arfen; Arthralgen; Asetam; Asomal; Aspac; Asplin; Atasol; Atralidon; Babikan; Bacetamol; Banesin; Benmyo; Biocetamol; Cadafen; Calapol; Calmanticold; Calonal; Calpol; Capital; Captin; Causalon; Cefalex; Cetadol; Codabrol; Codalgin; Codapane; Codicet; Codisal; Codoliprane; Cofamol; Conacetol; Cosutone; Cuponol; Curadon; Curpol; Custodial; Dafalgan; Darocet; Darvocet; Daygrip; Deminofen; Democyl; Demogripal; Desfebre; Dhamol; Dimindol; Dirox; Disprol; Dolcor; Dolefin; Dolegrippin; Dolgesic; Doliprane; Dolko; Dolofugin; Doloreduct; Dolorfug; Dolorstop; Dolotec; Dolprone; Dorocoff; Dresan; Dristancito; Duaneo; Dularin; Duorol; Duracetamol; Durapan; Dypap; Ecosetol; Elixodyne; Empracet; Enelfa; Eneril; Excipain; Exdol; Fanalgic; Farmadol; Febranine; Febrectal; Febrectol; Febrex; Febricet; Febrin; Febrinol; Fendon; Fensum; Fepanil; Fevor; Finiweh; Fluparmol; Geluprane; Genapap; Genebs; Grippostad; Gynospasmine; Hedex; Ildamol; Inalgex; Infadrops; Janupap; Kataprin; Korum; Labamol; Lekadol; Lemgrip; Lemsip; Liqiprine; Lupocet; Lyteca; Magnidol; Malgis; Malidens; Maxadol; Medocodene; Mexalen; Minafen; Minoset; Miralgin; Momentum; NEBS; Napafen; Nealgyl; NeoCitran; Neodol; Neodolito; Neopap; Neotrend; Neuridon; NilnOcen; Nina; Nobedon; Nodolex; Noral; Ofirmev; Oltyl; Oralgan; Ortensan; Oxycocet; Paceco; Pacemo; Pacemol; Pacet; Pacimol; Paedialgon; Paedol; Painex; Paldesic; Pamol; Panacete; Panadeine; Panadiene; Panaleve; Panamax; Panasorb; Panasorbe; Panets; Panex; Panodil; Panofen; Pantalgin; Paracemol; Paracenol; Paracetamole; Paracetamolo; Paracetanol; Paracetol; Paracin; Paracod; Paracodol; Parador; Paradrops; Parakapton; Parake; Paralen; Paralief; Paralink; Paralyoc; Paramol; Paramolan; Paranox; Parapan; Parasedol; Parasin; Paraspen; Parcetol; Parelan; Parmol; Parogal; Paroma; Pasolind; Pediapirin; Pediatrix; Pedric; Perfalgan; Phendon; Phenipirin; Phogoglandin; Pinex; Piramin; Pirinasol; Plicet; Polmofen; Predimol; Predualito; Prodol; Prompt; Prontina; Puernol; Pulmofen; Pyrigesic; Pyromed; Redutemp; Reliv; Remedol; Rivalgyl; Robigesic; Rounox; RubieMol; Rubophen; Rupemol; Salzone; Sanicet; Sanicopyrine; Scanol; Scentalgyl; Schmerzex; Sedalito; Semolacin; Seskamol; Setakop; Setamol; Setol; Sifenol; Sinaspril; Sinedol; Sinmol; Stanback; Stopain; Sunetheton; Supofen; Suppap; TYL; Tachiprina; Tapanol; Tapar; Tazamol; Temlo; Tempanal; Tempra; Termacet; Termalgin; Termalgine; Termofren; Tiffy; Titralgan; Treuphadol; Tricoton; Tylex; Tylol; Tymol; Upsanol; Utragin; Valorin; Veralgina; Vermidon; Verpol; Vips; Viruflu; Vivimed; Volpan; Zatinol; Zolben; Aceta Elixir; Actifed Plus; Aspirin free anacin; Bayer Select; D oliprane; Dymadon Co; Fortalidon P; Gattaphen T; Gripin Bebe; Helon N; Influbene N; Jin Gang; Lonarid Mono; Lyteca Syrup; Malex N; Panadeine Co; Panale ve; Pasolind N; Spalt N; Supadol mono; Toximer P; Treupel N; Treupel mon; Ty lenol; Tylex CD; Anacin 3; A-Per; Accu-Tap; Ultracet Click to Show/Hide
Disease Class	MG30-MG3Z: Pain
Therapeutic Class	Analgesics
Structure
Structure	3D Structure		2D Structure
Formula	C8H9NO2
InChI	1S/C8H9NO2/c1-6(10)9-7-2-4-8(11)5-3-7/h2-5,11H,1H3,(H,9,10)
InChIKey	RZVAJINKPMORJF-UHFFFAOYSA-N
Canonical SMILES	CC(=O)NC1=CC=C(C=C1)O
External Link
	Pubchem ID	1983
	CAS Number	103-90-2
	CHEBI ID	46195
	TTD ID	D0U5QK
	INTEDE ID	DR0037
	VARIDT ID	DR01006

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM001 Affected gastrointestinal absorption AM002 Affected cellular transport AM004 Affected intra/extra-hepatic metabolism AM006 Pharmacodynamic additive effects BM001 Altered gastrointestinal dynamics BM003 Complex formation BM004 Adsorption BM011 Transporter induction BM017 CYP450 enzyme inhibition BM019 UGT inhibition BM022 CYP450 enzyme induction BM023 UGT induction BM025 Decreased metabolism (Unspecific) BM044 Additive myelosuppressive effects BM050 Increased risk of bleeding BM055 Increased risk of hepatotoxicity BM071 Increased risk of methemoglobinemia BM083 Potentiated the pharmacological effects (Unspecific)
Relation Graph

Full list of drugs interacting with Acetaminophen
Affected gastrointestinal absorption
	Altered gastrointestinal dynamics					Drug Num: 22
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0123		Atropine	C17H23NO3	174174	Minor		Inter Info	[129], [130], [131]
D0154		Belladonna	C34H42N2O4	265028	Minor		Inter Info	[129], [130], [131]
D0183		Biperiden	C21H29NO	2381	Minor		Inter Info	[129], [130], [131]
D0353		Clidinium	C22H26NO3+	2784	Minor		Inter Info	[129], [130], [131]
D0424		Darifenacin	C28H30N2O2	444031	Minor		Inter Info	[129], [130], [131]
D0482		Dicyclomine	C19H35NO2	3042	Minor		Inter Info	[129], [130], [131]
D0662		Flavoxate	C24H25NO4	3354	Minor		Inter Info	[129], [130], [131]
D0733		Glycopyrronium	C19H28NO3+	3494	Minor		Inter Info	[129], [130], [131]
D0782		Hyoscyamine	C17H23NO3	154417	Minor		Inter Info	[129], [130], [131]
D0936		Liraglutide	C172H265N43O51	16134956	Minor		Inter Info	[136]
D1000		Mepenzolate	C21H26NO3+	4057	Minor		Inter Info	[129], [130], [131]
D1031		Methscopolamine	C18H24NO4+	71183	Minor		Inter Info	[129], [130], [131]
D1046		Metoclopramide	C14H22ClN3O2	4168	Minor		Inter Info	[22], [65], [130], [137]
D1202		Oxybutynin	C22H31NO3	4634	Minor		Inter Info	[129], [130], [131]
D1347		Procyclidine	C19H29NO	4919	Minor		Inter Info	[129], [130], [131]
D1354		Propantheline	C23H30NO3+	4934	Minor		Inter Info	[129], [130], [131]
D1450		Scopolamine	C17H21NO4	3000322	Minor		Inter Info	[129], [130], [131]
D1491		Solifenacin	C23H26N2O2	154059	Minor		Inter Info	[129], [130], [131]
D1607		Tolterodine	C22H31NO	443879	Minor		Inter Info	[129], [130], [131]
D1641		Trihexyphenidyl	C20H31NO	5572	Minor		Inter Info	[129], [130], [131]
D0160		Benzatropine	C21H25NO	1201549	Minor		Inter Info	[129], [130], [131]
D1656		Trospium	C25H30NO3+	5284632	Minor		Inter Info	[129], [130], [131]
	Complex formation					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0329		Cholestyramine	C27H47ClN2	137699107	Minor		Inter Info	[132]
	Adsorption					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0021		Activated charcoal	C	5462310	Moderate		Inter Info	[25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49]
Affected cellular transport
Affected intra/extra-hepatic metabolism
	CYP450 enzyme inhibition					Drug Num: 10
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0302		Ceritinib	C28H36ClN5O3S	57379345	Moderate		Inter Info	[22], [65], [86]
D0432		Deferasirox	C21H15N3O4	214348	Moderate		Inter Info	[88]
D0545		Echinacea	NA	NA	Moderate		Inter Info	[89]
D0642		Fenofibrate	C20H21ClO4	3339	Moderate		Inter Info	[22], [65], [97]
D0724		Givosiran	C78H139N11O30	119058042	Moderate		Inter Info	[98]
D0732		Glycerol phenylbutyrate	C33H38O6	10482134	Moderate		Inter Info	[65], [99]
D1432		Rucaparib	C19H18FN3O	9931954	Moderate		Inter Info	[86]
D1687		Vemurafenib	C23H18ClF2N3O3S	42611257	Moderate		Inter Info	[126]
D0084		Anagrelide	C10H7Cl2N3O	135409400	Moderate		Inter Info	[22], [65], [127]
D1197		Oxazepam	C15H11ClN2O2	4616	Minor		Inter Info	[138]
	UGT inhibition					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1191		Ospemifene	C24H23ClO2	3036505	Moderate		Inter Info	[65], [111], [112]
D1528		Tafamidis	C14H7Cl2NO3	11001318	Moderate		Inter Info	[65], [121], [122]
	CYP450 enzyme induction					Drug Num: 19
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0071		Amobarbital	C11H18N2O3	2164	Moderate		Inter Info	[50], [51], [52], [53]
D0095		Apalutamide	C21H15F4N5O2S	24872560	Moderate		Inter Info	[65], [66]
D0255		Carbamazepine	C15H12N2O	2554	Moderate		Inter Info	[83], [84], [85]
D0621		Ethotoin	C11H12N2O2	3292	Moderate		Inter Info	[93], [94], [95], [83], [96], [7]
D0697		Fosphenytoin	C16H15N2O6P	56339	Moderate		Inter Info	[93], [94], [95], [83], [96], [7]
D0858		Isoniazid	C6H7N3O	3767	Moderate		Inter Info	[103], [104], [105], [106], [107]
D1003		Mephenytoin	C12H14N2O2	4060	Moderate		Inter Info	[93], [94], [95], [83], [96], [7]
D1024		Methohexital	C14H18N2O3	9034	Moderate		Inter Info	[50], [51], [52], [53]
D1040		Methylphenobarbital	C13H14N2O3	8271	Moderate		Inter Info	[51], [52], [53]
D1265		Phenobarbital	C12H12N2O3	4763	Moderate		Inter Info	[50], [51], [52], [53]
D1302		Pitolisant	C17H26ClNO	9948102	Moderate		Inter Info	[65], [117]
D1340		Primidone	C12H14N2O2	4909	Moderate		Inter Info	[50], [51], [52], [53]
D1453		Secobarbital	C12H18N2O3	5193	Moderate		Inter Info	[50], [51], [52], [53]
D1518		Sulfinpyrazone	C23H20N2O3S	5342	Moderate		Inter Info	[83]
D1573		Thiopental	C11H18N2O2S	3000715	Moderate		Inter Info	[50], [51], [52], [53]
D0224		Butabarbital	C10H16N2O3	2479	Moderate		Inter Info	[50], [51], [52], [53]
D0225		Butalbital	C11H16N2O3	2481	Moderate		Inter Info	[50], [51], [52], [53]
D1248		Pentobarbital	C11H18N2O3	4737	Moderate		Inter Info	[50], [51], [52], [53]
D1283		Phenytoin	C15H12N2O2	1775	Moderate		Inter Info	[93], [94], [95], [83], [96], [7]
	UGT induction					Drug Num: 3
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0953		Lorlatinib	C21H19FN6O2	71731823	Moderate		Inter Info	[22], [65], [108]
D0619		Ethinylestradiol	C20H24O2	5991	Minor		Inter Info	[133], [134], [135]
D1011		Mestranol	C21H26O2	6291	Minor		Inter Info	[133], [134], [135]
	Decreased metabolism (Unspecific)					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1357		Propranolol	C16H21NO2	4946	Minor		Inter Info	[141], [142]
Pharmacodynamic additive effects
	Increased risk of bleeding					Drug Num: 3
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0087		Anisindione	C16H12O3	2197	Moderate		Inter Info	[54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64]
D1711		Warfarin	C19H16O4	54678486	Moderate		Inter Info	[54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64]
D0481		Dicoumarol	C19H12O6	54676038	Moderate		Inter Info	[59], [61], [63]
	Increased risk of hepatotoxicity					Drug Num: 30
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0617		Ethanol	C2H6O	702	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12]
D0900		Leflunomide	C12H9F3N2O2	3899	Major		Inter Info	[13], [14], [15]
D0944		Lomitapide	C39H37F6N3O2	9853053	Major		Inter Info	[16]
D1073		Mipomersen	C230H324N67O122P19S19	118984467	Major		Inter Info	[17]
D1258		Pexidartinib	C20H15ClF3N5	25151352	Major		Inter Info	[21]
D1556		Teriflunomide	C12H9F3N2O2	54684141	Major		Inter Info	[13], [14], [15]
D0113		Asparaginase Erwinia chrysanthemi	NA	NA	Moderate		Inter Info	[67], [68], [69], [22], [65], [70], [71], [72], [73], [74], [75], [76], [77]
D0149		Bedaquiline	C32H31BrN2O2	5388906	Moderate		Inter Info	[78]
D0199		Brentuximab vedotin	NA	NA	Moderate		Inter Info	[81]
D0232		Calaspargase pegol	NA	NA	Moderate		Inter Info	[67], [68], [69], [22], [65], [70], [71], [72], [73], [74], [75], [76], [77]
D0248		Cannabidiol	C21H30O2	644019	Moderate		Inter Info	[65], [82]
D0357		Clofarabine	C10H11ClFN5O3	119182	Moderate		Inter Info	[87]
D0554		Efavirenz	C14H9ClF3NO2	64139	Moderate		Inter Info	[90], [91]
D0584		Epirubicin	C27H29NO11	41867	Moderate		Inter Info	[22], [65], [92]
D0789		Idelalisib	C22H18FN7O	11625818	Moderate		Inter Info	[100]
D0793		Imatinib	C29H31N7O	5291	Moderate		Inter Info	[101], [102]
D1025		Methotrexate	C20H22N8O5	126941	Moderate		Inter Info	[65], [109]
D1106		Naltrexone	C20H23NO4	5360515	Moderate		Inter Info	[110]
D1239		Peginterferon beta-1a	NA	NA	Moderate		Inter Info	[113], [114], [115], [116]
D1389		Remdesivir	C27H35N6O8P	121304016	Moderate		Inter Info	[22], [65], [118], [119], [120]
D1589		Tioguanine	C5H5N5S	2723601	Moderate		Inter Info	[123], [124]
D1615		Trabectedin	C39H43N3O11S	108150	Moderate		Inter Info	[65], [125]
D0114		Asparaginase Escherichia coli	NA	NA	Moderate		Inter Info	[67], [68], [69], [22], [65], [70], [71], [72], [73], [74], [75], [76], [77]
D0826		Interferon beta-1a	NA	NA	Moderate		Inter Info	[113], [114], [115], [116]
D0827		Interferon beta-1b	NA	NA	Moderate		Inter Info	[113], [114], [115], [116]
D1234		Pegaspargase	C14H19NO	436058	Moderate		Inter Info	[67], [68], [69], [22], [65], [70], [71], [72], [73], [74], [75], [76], [77]
D1381		Ranitidine	C13H22N4O3S	3001055	Minor		Inter Info	[143], [144]
D1382		Ranitidine (bismuth citrate)	C13H22N4O3S	3001055	Minor		Inter Info	[143], [144]
D1400		Rifampicin	C43H58N4O12	135398735	Minor		Inter Info	[50], [107], [145]
D1720		Zidovudine	C10H13N5O4	35370	Minor		Inter Info	[146], [147], [148], [149], [150], [151]
	Increased risk of methemoglobinemia					Drug Num: 15
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1148		Nitrous acid	HNO2	24529	Major		Inter Info	[18], [19], [20]
D1337		Prilocaine	C13H20N2O	4906	Major		Inter Info	[22], [23], [24]
D1338		Prilocaine (topical)	C13H20N2O	4906	Major		Inter Info	[13], [22], [24]
D0163		Benzocaine (topical)	C9H11NO2	2337	Moderate		Inter Info	[65], [79], [80]
D0339		Cinchocaine (topical)	C20H29N3O2	3025	Moderate		Inter Info	[65], [79], [80]
D0377		Cocaine (nasal)	C17H21NO4	446220	Moderate		Inter Info	[65], [79], [80]
D0378		Cocaine (topical)	C17H21NO4	446220	Moderate		Inter Info	[65], [79], [80]
D1852		Oxybuprocaine (ophthalmic)	C17H28N2O3	4633	Moderate		Inter Info	[65], [79], [80]
D1870		Proparacaine (ophthalmic)	C16H26N2O3	4935	Moderate		Inter Info	[65], [79], [80]
D1904		Tetracaine (ophthalmic)	C15H24N2O2	5411	Moderate		Inter Info	[65], [79], [80]
D1562		Tetracaine (topical)	C15H24N2O2	5411	Moderate		Inter Info	[65], [79], [80]
D0419		Dapsone	C12H12N2O2S	2955	Moderate		Inter Info	[22], [128]
D0420		Dapsone (topical)	C12H12N2O2S	2955	Moderate		Inter Info	[22], [128]
D1835		Lidocaine (ophthalmic)	C14H22N2O	3676	Moderate		Inter Info	[65], [79], [80]
D0928		Lidocaine (topical)	C14H22N2O	3676	Moderate		Inter Info	[65], [79], [80]
	Potentiated the pharmacological effects (Unspecific)					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1341		Probenecid	C13H19NO4S	4911	Minor		Inter Info	[139], [140]

References
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