Drug General Information (ID: DDI46C2DIQ)
  Drug Name Acetaminophen Drug Info Solifenacin Drug Info
  Drug Type Small molecule Small molecule
  Therapeutic Class Analgesics Antispasmodics
  Structure

 Mechanism of Acetaminophen-Solifenacin Interaction (Severity Level: Minor)
     Altered gastrointestinal dynamics Click to Show/Hide Mechanism Graph
Could Not Find 2D Structure
      Drug Name Acetaminophen Solifenacin
      Mechanism Absorption affected by delayed gastric emptying Delayed gastric emptying
      Key Mechanism Factor 1
Factor Name Gastrointestinal Motility
Factor Description Gastrointestinal motility is an important factor in determining the absorption of orally administered drugs, and it controls the residence time of the drug in the digestive tract.
      Mechanism Description
  • Altered absorption of Acetaminophen due to GI dynamics variation caused by Solifenacin 

References
1 Clark JM, Seager SJ "Gastric emptying following premedication with glycopyrrolate or atropine." Br J Anaesth 55 (1983): 1195-9. [PMID: 6652009]
2 Nimmo J, Heading RC, Tothill P, Prescott LF "Pharmacological modification of gastric emptying: effects of propantheline and metoclopramide on paracetamol absorption." Br Med J 1 (1973): 587-9. [PMID: 4694406]
3 Product Information. Transderm Scop (scopolamine). Ciba Self-Medication Inc, Woodbridge, NJ.