Drug General Information (ID: DDIXZ4P25K)
  Drug Name Acetaminophen Drug Info Propranolol Drug Info
  Drug Type Small molecule Small molecule
  Therapeutic Class Analgesics Antianxiety Agents
  Structure

 Mechanism of Acetaminophen-Propranolol Interaction (Severity Level: Minor)
     Decreased metabolism (Unspecific) Click to Show/Hide Mechanism Graph
      Drug Name Acetaminophen Propranolol
      Mechanism Acetaminophen Inhibit the hepatic metabolism of acetaminophen
      Key Mechanism Factor 1
Factor Name Pharmacokinetics
Factor Description Alters the metabolism of the drug, leading to changes in the plasma concentration of the drug and affecting the pharmacological effects.
      Mechanism Description
  • Decreased metabolism of Acetaminophen caused by Propranolol 

References
1 Baraka OZ, Truman CA, Ford JM, Roberts CJ. The effect of propranolol on paracetamol metabolism in man.?Br J Clin Pharmacol. 1990;29(2):261-264. [PMID: 2306420]
2 Baraka OZ, Truman CA, Ford JM, Roberts JC "The effect of propranolol on paracetamol metabolism in man." Br J Clin Pharmacol 29 (1990): 261-4. [PMID: 2306420]