Drug General Information (ID: DDICGBD8W1)
Drug Name			Acetaminophen		Drug Info		Rifampicin		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Analgesics				Antituberculosis Agents
Structure

Mechanism of Acetaminophen-Rifampicin Interaction (Severity Level: Minor)
Increased risk of hepatotoxicity Click to Show/Hide Mechanism Graph
Drug Name		Acetaminophen				Rifampicin
Mechanism		Hepatotoxicity				Hepatotoxicity
Key Mechanism Factor 1
		Factor Name		Hepatotoxicity
		Factor Description		Combination of drugs that can induce hepatotoxicity may increase the risk of liver injury. Symptoms vary depending on the level of exposure and the total extent of liver damage, and may cause few symptoms if the damage is mild, and eventually lead to liver failure in patients with severe damage.
Mechanism Description		Increased risk of hepatotoxicity by the combination of Acetaminophen and Rifampicin

References
1	Bock KW, Wiltfang J, Blume R, Ullrich D, Bircher J "Paracetamol as a test drug to determine glucuronide formation in man: effects of inducers and of smoking." Eur J Clin Pharmacol 31 (1987): 677-83. [PMID: 3556375]
2	Nolan CM, Sandblom RE, Thummel KE, Slattery JT, Nelson SD "Hepatotoxicity associated with acetaminophen usage in patients receiving multiple drug therapy for tuberculosis." Chest 105 (1994): 408-11. [PMID: 7508362]
3	Prescott LF, Critchley JA, Balali-Mood M, Pentland B "Effects of microsomal enzyme induction on paracetamol metabolism in man." Br J Clin Pharmacol 12 (1981): 149-53. [PMID: 7306429]