Drug General Information (ID: DDIMFHUO50)
  Drug Name Acetaminophen Drug Info Ranitidine (bismuth citrate) Drug Info
  Drug Type Small molecule Small molecule
  Therapeutic Class Analgesics Antiulcer Agents
  Structure

 Mechanism of Acetaminophen-Ranitidine (bismuth citrate) Interaction (Severity Level: Minor)
     Increased risk of hepatotoxicity Click to Show/Hide Mechanism Graph
Could Not Find 2D Structure
      Drug Name Acetaminophen Ranitidine (bismuth citrate)
      Mechanism Hepatotoxicity Hepatotoxicity
      Key Mechanism Factor 1
Factor Name Hepatotoxicity
Factor Description Combination of drugs that can induce hepatotoxicity may increase the risk of liver injury. Symptoms vary depending on the level of exposure and the total extent of liver damage, and may cause few symptoms if the damage is mild, and eventually lead to liver failure in patients with severe damage.
      Mechanism Description
  • Increased risk of hepatotoxicity by the combination of Acetaminophen and Ranitidine (bismuth citrate) 

References
1 Jack D, Thomas M, Skidmore IF "Ranitidine and paracetamol metabolism." Lancet 2 (1985): 1067. [PMID: 2865542]
2 Rogers SA, Gale KC, Newton JF, et al "Inhibition by ranitidine of acetaminophen conjugation and its possible role in ranitidine potentiation of acetaminophen-induced hepatotoxicity." J Pharmacol Exp Ther 245 (1988): 887-94. [PMID: 3133464]