Drug General Information (ID: DDIRZXM194)
  Drug Name Acetaminophen Drug Info Probenecid Drug Info
  Drug Type Small molecule Small molecule
  Therapeutic Class Analgesics Uricosuric Agents
  Structure

 Mechanism of Acetaminophen-Probenecid Interaction (Severity Level: Minor)
     Potentiated the pharmacological effects (Unspecific) Click to Show/Hide Mechanism Graph
      Drug Name Acetaminophen Probenecid
      Mechanism Acetaminophen Increase the therapeutic effects of acetaminophen
      Key Mechanism Factor 1
Factor Name Pharmacodynamics
Factor Description Enhanced pharmacological effects leading to increased adverse reactions.
      Mechanism Description
  • Potentiate the pharmacologic effects by the combination of Acetaminophen and Probenecid 

References
1 Abernethy DR, Greenblatt DJ, Ameer B, Shader RI "Probenecid impairment of acetaminophen and lorazepam clearance: direct inhibition of ether glucuronide formation." J Pharmacol Exp Ther 234 (1985): 345-9. [PMID: 4020675]
2 Kamali F, Fry JR, Bell GD "Salivary excretion of paracetamol in man." J Pharm Pharmacol 39 (1987): 150-2