Drug General Information (ID: DDINYBUP5E)
Drug Name			Zidovudine		Drug Info		Amphotericin B (lipid complex)		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Anti-Hiv Agents				Antifungal Agents
Structure

Mechanism of Zidovudine-Amphotericin B (lipid complex) Interaction (Severity Level: Moderate)
Additive myelosuppressive effects Click to Show/Hide Mechanism Graph
Drug Name		Zidovudine				Amphotericin B (lipid complex)
Mechanism 1		Myelosuppressive effects				Myelosuppressive effects
Key Mechanism Factor 1
		Factor Name		Myelosuppressive effects
		Factor Description		Myelosuppression, also known as bone marrow suppression, is a decrease in bone marrow activity that leads to a decrease in the production of blood cells. Some blood cell disorders include: erythrocytopenia (anemia), leukopenia (neutropenia), and thrombocytopenia (thrombocytopenia).
Mechanism Description		Additive myelosuppressive effects by the combination of Zidovudine and Amphotericin B (lipid complex)
Increased risk of nephrotoxicity Click to Show/Hide Mechanism Graph
Drug Name		Zidovudine				Amphotericin B (lipid complex)
Mechanism 2		Nephrotoxicity				Nephrotoxicity
Key Mechanism Factor 2
		Factor Name		Nephrotoxicity
		Factor Description		The combination of drugs that can induce nephrotoxicity may increase the risk of kidney injury. When kidney injury occurs, the inability to remove excess urine and waste from the body can lead to high levels of urea nitrogen, creatinine, and electrolytes (such as potassium and magnesium) in the blood.
Mechanism Description		Increased risk of nephrotoxicity by the combination of Zidovudine and Amphotericin B (lipid complex)

Recommended Action
Management		If these drugs are used together, the patient's renal and hematologic function should be closely monitored.

References
1	Lotterer E, Ruhnke M, Trautman M, et al "Decreased and variable systemic availability of zidovudine in patients with AIDS if administered with a meal." Eur J Clin Pharmacol 40 (1991): 305-8. [PMID: 2060570]
2	Product Information. Abelcet (amphotericin B). Liposome Company Inc, The, Princeton, NJ.
3	Unadkat JD, Collier AC, Crosby SS, et al "Pharmacokinetics of oral zidovudine (azidothymidine) in patients with AIDS when administered with and without a high-fat meal." AIDS 4 (1990): 229-32. [PMID: 2350441]