Details of Drug

Drug General Information (ID: D0077)
Drug Name	Amphotericin B (lipid complex)
Drug Type	Small molecule
Drug Synonymous	ABLC; Abelcet; Abelecet; Ambisome; Amphocin; Amphomoronal; Amphotec; Amphotericin; Amphotericinum; Amphotherizin; Amphozone; Fungilin; Fungisome; Fungisone; Fungizone; Halizon; SinuNase; Amfotericina B; Amophotericin B; Amphortericin B; Amphotericin B Cholesterol Dispersion; Amphotericin B Colloidal Dispersion; Amphotericin B liposomal; Amphotericin BETA; Amphotericine B; Amphotericinum B; Amphotherizin [German]; Liposomal Amphotericin B; NCI527017; NS 718; AMPH-B; Abelcet (TN); AmBisome (TN); Amfotericina B [INN-Spanish]; Ampho-Moronal; Amphocil (TN); Amphotec (TN); Amphotericin-B; Amphotericine B [INN-French]; Amphotericinum B [INN-Latin]; Fungilin (TN); Fungisome (TN); Fungizone (TN); LNS-AmB; Mysteclin-F; NKTR-024; Amphotericin B [USAN:INN:JAN]; Amphotericin B, Lipid-based; Amphotericin B, Streptomyces sp.; Amphotericin B (JP15/USP/INN) Click to Show/Hide
Disease Class	1F29-1F2F: Fungal infection; 1F2Z: Mycose
Therapeutic Class	Antifungal Agents
Structure
Structure	3D Structure		2D Structure
Formula	C47H73NO17
InChI	1S/C47H73NO17/c1-27-17-15-13-11-9-7-5-6-8-10-12-14-16-18-34(64-46-44(58)41(48)43(57)30(4)63-46)24-38-40(45(59)60)37(54)26-47(61,65-38)25-33(51)22-36(53)35(52)20-19-31(49)21-32(50)23-39(55)62-29(3)28(2)42(27)56/h5-18,27-38,40-44,46,49-54,56-58,61H,19-26,48H2,1-4H3,(H,59,60)/b6-5+,9-7+,10-8+,13-11+,14-12+,17-15+,18-16+/t27-,28-,29-,30+,31+,32+,33-,34-,35+,36+,37-,38-,40+,41-,42+,43+,44-,46-,47+/m0/s1
InChIKey	APKFDSVGJQXUKY-INPOYWNPSA-N
Canonical SMILES	CC1C=CC=CC=CC=CC=CC=CC=CC(CC2C(C(CC(O2)(CC(CC(C(CCC(CC(CC(=O)OC(C(C1O)C)C)O)O)O)O)O)O)O)C(=O)O)OC3C(C(C(C(O3)C)O)N)O
External Link
	Pubchem ID	5280965
	CAS Number	1397-89-3
	TTD ID	D02DWM
	INTEDE ID	DR2632
	VARIDT ID	DR01468

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM005 Affected excretion pathways AM006 Pharmacodynamic additive effects AM007 Pharmacodynamic antagonistic effects BM027 Decreased renal excretion due to nephrotoxicity BM043 Additive immunosuppressive effects BM044 Additive myelosuppressive effects BM045 Additive neuromuscular blocking effects BM063 Increased risk of hypocalcemia BM065 Increased risk of hypokalemia BM066 Increased risk of hypomagnesemia BM072 Increased risk of nephrotoxicity BM081 Increased risk of ventricular arrhythmias BM107 Attenuated pharmacological effects (Unspecific)
Relation Graph

Full list of drugs interacting with Amphotericin B (lipid complex)
Affected excretion pathways
	Decreased renal excretion due to nephrotoxicity					Drug Num: 5
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1389		Remdesivir	C27H35N6O8P	121304016	Moderate		Inter Info	[16], [59], [60]
D1543		Telbivudine	C10H14N2O5	159269	Moderate		Inter Info	[63]
D0576		Entecavir	C12H15N5O3	135398508	Moderate		Inter Info	[70]
D1193		Oxaliplatin	C8H14N2O4Pt	9887053	Moderate		Inter Info	[71]
D1241		Pemetrexed	C20H21N5O6	135410875	Moderate		Inter Info	[75]
Pharmacodynamic additive effects
	Additive immunosuppressive effects					Drug Num: 3
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1375		Radium Ra 223 dichloride	NA	NA	Moderate		Inter Info	[58]
D1487		Sodium phosphate, monobasic (p32)	NA	NA	Moderate		Inter Info	[61]
D1509		Strontium chloride Sr-89	Cl2Sr	5388879	Moderate		Inter Info	[40], [16], [62]
	Additive myelosuppressive effects					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1720		Zidovudine	C10H13N5O4	35370	Moderate		Inter Info	[76], [38], [77]
	Additive neuromuscular blocking effects					Drug Num: 12
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0122		Atracurium	C53H72N2O12+2	47319	Moderate		Inter Info	[41], [42], [43]
D0522		Doxacurium	C56H78N2O16+2	60169	Moderate		Inter Info	[41], [42], [43]
D1047		Metocurine	C40H48N2O6+2	21233	Moderate		Inter Info	[41], [42], [43]
D1080		Mivacurium	C58H80N2O14+2	5281042	Moderate		Inter Info	[41], [42], [43]
D1219		Pancuronium	C35H60N2O4+2	441289	Moderate		Inter Info	[41], [42], [43]
D1295		Pipecuronium	C35H62N4O4+2	50192	Moderate		Inter Info	[41], [42], [43]
D1384		Rapacuronium	C37H61N2O4+	5311399	Moderate		Inter Info	[41], [42], [43]
D1420		Rocuronium	C32H53N2O4+	441290	Moderate		Inter Info	[41], [42], [43]
D1659		Tubocurarine	C37H41N2O6+	6000	Moderate		Inter Info	[41], [42], [43]
D1684		Vecuronium	C34H57N2O4+	39765	Moderate		Inter Info	[41], [42], [43]
D0343		Cisatracurium	C53H72N2O12+2	62887	Moderate		Inter Info	[41], [42], [43]
D1510		Succinylcholine	C14H30N2O4+2	5314	Moderate		Inter Info	[41], [42], [43]
	Increased risk of hypocalcemia					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0694		Foscarnet	CH3O5P	3415	Major		Inter Info	[31], [32], [33]
	Increased risk of hypokalemia					Drug Num: 28
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0012		Acetazolamide	C4H6N4O3S2	1986	Moderate		Inter Info	[16]
D0217		Bumetanide	C17H20N2O5S	2471	Moderate		Inter Info	[16]
D0392		Corticotropin	C207H308N56O58S	16132265	Moderate		Inter Info	[47], [48], [49]
D0436		Deflazacort	C25H31NO6	189821	Moderate		Inter Info	[47], [48], [49]
D0453		Dexamethasone	C22H29FO5	5743	Moderate		Inter Info	[47], [48], [49]
D0479		Diclofenamide	C6H6Cl2N2O4S2	3038	Moderate		Inter Info	[16]
D0613		Etacrynic acid	C13H12Cl2O4	3278	Moderate		Inter Info	[16]
D0671		Fludrocortisone	C21H29FO5	31378	Moderate		Inter Info	[47], [48], [49]
D0704		Furosemide	C12H11ClN2O5S	3440	Moderate		Inter Info	[16]
D0771		Hydrochlorothiazide	C7H8ClN3O4S2	3639	Moderate		Inter Info	[16]
D0773		Hydrocortisone	C21H30O5	5754	Moderate		Inter Info	[47], [48], [49]
D0775		Hydroflumethiazide	C8H8F3N3O4S2	3647	Moderate		Inter Info	[16]
D0798		Indapamide	C16H16ClN3O3S	3702	Moderate		Inter Info	[16]
D0926		Licorice	C42H62O16Zn	163463	Moderate		Inter Info	[54], [55], [56]
D1018		Methazolamide	C5H8N4O3S2	4100	Moderate		Inter Info	[16]
D1041		Methylprednisolone	C22H30O5	6741	Moderate		Inter Info	[47], [48], [49]
D1311		Polythiazide	C11H13ClF3N3O4S3	4870	Moderate		Inter Info	[16]
D1332		Prednisolone	C21H28O5	5755	Moderate		Inter Info	[47], [48], [49]
D1563		Tetracosactide	C136H210N40O31S	16133802	Moderate		Inter Info	[47], [48], [49]
D1633		Trichlormethiazide	C8H8Cl3N3O4S2	5560	Moderate		Inter Info	[16]
D0148		Beclomethasone dipropionate	C28H37ClO7	21700	Moderate		Inter Info	[47], [48], [49]
D0158		Bendroflumethiazide	C15H14F3N3O4S2	2315	Moderate		Inter Info	[16]
D0166		Benzthiazide	C15H14ClN3O4S3	2343	Moderate		Inter Info	[16]
D0326		Chlorthalidone	C14H11ClN2O4S	2732	Moderate		Inter Info	[16]
D1048		Metolazone	C16H16ClN3O3S	4170	Moderate		Inter Info	[16]
D1334		Prednisone	C21H26O5	5865	Moderate		Inter Info	[47], [48], [49]
D1611		Torasemide	C16H20N4O3S	41781	Moderate		Inter Info	[16]
D1628		Triamcinolone	C21H27FO6	31307	Moderate		Inter Info	[47], [48], [49]
	Increased risk of hypomagnesemia					Drug Num: 6
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0458		Dexlansoprazole	C16H14F3N3O2S	9578005	Moderate		Inter Info	[50], [51], [52]
D0603		Esomeprazole	C17H19N3O3S	9568614	Moderate		Inter Info	[50], [51], [52]
D1373		Rabeprazole	C18H21N3O3S	5029	Moderate		Inter Info	[50], [51], [52]
D0892		Lansoprazole	C16H14F3N3O2S	3883	Moderate		Inter Info	[50], [51], [52]
D1179		Omeprazole	C17H19N3O3S	4594	Moderate		Inter Info	[50], [51], [52]
D1222		Pantoprazole	C16H15F2N3O4S	4679	Moderate		Inter Info	[50], [51], [52]
	Increased risk of nephrotoxicity					Drug Num: 53
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0432		Deferasirox	C21H15N3O4	214348	Major		Inter Info	[6], [7]
D0629		Everolimus	C53H83NO14	6442177	Major		Inter Info	[9], [10], [11]
D0709		Gallium nitrate	GaN3O9	61635	Major		Inter Info	[12]
D0761		Human botulinum neurotoxin A/B immune globulin	NA	NA	Major		Inter Info	[13], [14], [15]
D0763		Human cytomegalovirus immune globulin	NA	NA	Major		Inter Info	[13], [14], [15]
D0768		Human Rho(D) immune globulin	NA	NA	Major		Inter Info	[13], [14], [15]
D0805		Inotersen	C230H318N69O121P19S19	121492004	Major		Inter Info	[16], [17]
D0831		Iodipamide	C20H14I6N2O6	3739	Major		Inter Info	[18], [19], [20]
D0832		Iodixanol	C35H44I6N6O15	3724	Major		Inter Info	[18], [19], [20]
D0833		Iohexol	C19H26I3N3O9	3730	Major		Inter Info	[18], [19], [20]
D0834		Iopamidol	C17H22I3N3O8	65492	Major		Inter Info	[18], [19], [20]
D0836		Iopromide	C18H24I3N3O8	3736	Major		Inter Info	[18], [19], [20]
D0837		Iothalamic acid	C11H9I3N2O4	3737	Major		Inter Info	[18], [19], [20]
D0838		Ioversol	C18H24I3N3O9	3741	Major		Inter Info	[18], [19], [20]
D0839		Ioxilan	C18H24I3N3O8	3743	Major		Inter Info	[18], [19], [20]
D1476		Sirolimus	C51H79NO13	5284616	Major		Inter Info	[9], [10], [11]
D1526		Tacrolimus	C44H69NO12	445643	Major		Inter Info	[9], [10], [11]
D1549		Temsirolimus	C56H87NO16	6918289	Major		Inter Info	[9], [10], [11]
D0335		Cidofovir	C8H14N3O6P	60613	Major		Inter Info	[26]
D0472		Diatrizoate	C11H9I3N2O4	2140	Major		Inter Info	[18], [19], [20]
D0765		Human immunoglobulin G (intravenous)	NA	NA	Major		Inter Info	[13], [14], [15]
D0056		Amikacin	C22H43N5O13	37768	Moderate		Inter Info	[37], [38], [39]
D0057		Amikacin (liposome)	C22H43N5O13	37768	Moderate		Inter Info	[37], [38], [39]
D0145		Balsalazide	C17H15N3O6	54585	Moderate		Inter Info	[44], [45], [46]
D0710		Ganciclovir	C9H13N5O4	135398740	Moderate		Inter Info	[40], [16], [53]
D0718		Gentamicin	C21H43N5O7	3467	Moderate		Inter Info	[37], [38], [39]
D0724		Givosiran	C78H139N11O30	119058042	Moderate		Inter Info	[40], [16]
D0790		Ifosfamide	C7H15Cl2N2O2P	3690	Moderate		Inter Info	[40], [16]
D0876		Kanamycin	C18H36N4O11	6032	Moderate		Inter Info	[37], [38], [39]
D0996		Melphalan	C13H18Cl2N2O2	460612	Moderate		Inter Info	[40], [16]
D1030		Methoxyflurane	C3H4Cl2F2O	4116	Moderate		Inter Info	[16]
D1120		Neomycin	C23H46N6O13	8378	Moderate		Inter Info	[37], [38], [39]
D1126		Netilmicin	C21H41N5O7	441306	Moderate		Inter Info	[37], [38], [39]
D1173		Olsalazine	C14H10N2O6	22419	Moderate		Inter Info	[44], [45], [46]
D1246		Pentamidine	C19H24N4O2	4735	Moderate		Inter Info	[57], [38]
D1304		Plazomicin	C25H48N6O10	42613186	Moderate		Inter Info	[37], [38], [39]
D1507		Streptomycin	C21H39N7O12	19649	Moderate		Inter Info	[37], [38], [39]
D1517		Sulfasalazine	C18H14N4O5S	5339	Moderate		Inter Info	[44], [45], [46]
D1597		Tobramycin	C18H37N5O9	36294	Moderate		Inter Info	[37], [38], [39]
D1667		Uracil mustard	C8H11Cl2N3O2	6194	Moderate		Inter Info	[40], [16]
D1676		Valganciclovir	C14H22N6O5	135413535	Moderate		Inter Info	[40], [16], [53]
D0252		Capreomycin	C50H88N28O15	3000502	Moderate		Inter Info	[40], [19], [64]
D0292		Ceftazidime	C22H22N6O7S2	5481173	Moderate		Inter Info	[40], [16]
D0312		Chlorambucil	C14H19Cl2NO2	2708	Moderate		Inter Info	[40], [16]
D0344		Cisplatin	Cl2H6N2Pt	5702198	Moderate		Inter Info	[40], [16]
D0357		Clofarabine	C10H11ClFN5O3	119182	Moderate		Inter Info	[65]
D0400		Cyclophosphamide	C7H15Cl2N2O2P	2907	Moderate		Inter Info	[40], [16]
D0402		Cyclosporine	C62H111N11O12	5284373	Moderate		Inter Info	[66], [67], [68]
D1009		Mesalazine	C7H7NO3	4075	Moderate		Inter Info	[44], [45], [46]
D1025		Methotrexate	C20H22N8O5	126941	Moderate		Inter Info	[40], [16]
D1217		Pamidronic acid	C3H11NO7P2	4674	Moderate		Inter Info	[72], [73], [74]
D1680		Vancomycin	C66H75Cl2N9O24	14969	Moderate		Inter Info	[40], [19], [64]
D1727		Zoledronic acid	C5H10N2O7P2	68740	Moderate		Inter Info	[72], [73], [74]
	Increased risk of ventricular arrhythmias					Drug Num: 17
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0066		Amiodarone	C25H29I2NO3	2157	Major		Inter Info	[1], [2], [3]
D0107		Arsenic trioxide	As2O3	14888	Major		Inter Info	[4], [5]
D0534		Dronedarone	C31H44N2O5S	208898	Major		Inter Info	[8]
D0909		Levacetylmethadol	C23H31NO2	15130	Major		Inter Info	[21], [22], [23]
D1292		Pimozide	C28H29F2N3O	16362	Major		Inter Info	[24], [25]
D0513		Dofetilide	C19H27N3O5S2	71329	Major		Inter Info	[27]
D0535		Droperidol	C22H22FN3O2	3168	Major		Inter Info	[28], [29], [30]
D1726		Ziprasidone	C21H21ClN4OS	60854	Major		Inter Info	[34], [35], [36]
D0067		Amisulpride	C17H27N3O4S	2159	Moderate		Inter Info	[40], [16]
D1215		Paliperidone	C23H27FN4O3	115237	Moderate		Inter Info	[40], [16]
D1413		Risperidone	C23H27FN4O2	5073	Moderate		Inter Info	[40], [16]
D1637		Trifluoperazine	C21H24F3N3S	5566	Moderate		Inter Info	[40], [16]
D0324		Chlorpromazine	C17H19ClN2S	2726	Moderate		Inter Info	[40], [16]
D0508		Disopyramide	C21H29N3O	3114	Moderate		Inter Info	[16], [69], [62]
D0678		Fluphenazine	C22H26F3N3OS	3372	Moderate		Inter Info	[40], [16]
D1351		Promazine	C17H20N2S	4926	Moderate		Inter Info	[40], [16]
D1574		Thioridazine	C21H26N2S2	5452	Moderate		Inter Info	[40], [16]
Pharmacodynamic antagonistic effects
	Attenuated pharmacological effects (Unspecific)					Drug Num: 6
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0867		Itraconazole	C35H38Cl2N8O4	55283	Minor		Inter Info	[78], [79], [80]
D0880		Ketoconazole	C26H28Cl2N4O4	456201	Minor		Inter Info	[78], [79], [80]
D1057		Miconazole	C18H14Cl4N2O	4189	Minor		Inter Info	[78], [79], [80]
D0367		Clotrimazole	C22H17ClN2	2812	Minor		Inter Info	[78], [79], [80]
D0667		Fluconazole	C13H12F2N6O	3365	Minor		Inter Info	[78], [79], [80]
D1706		Voriconazole	C16H14F3N5O	71616	Minor		Inter Info	[78], [79], [80]

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