Drug General Information (ID: DDIVSW2XIH)
  Drug Name Amphotericin B (lipid complex) Drug Info Miconazole Drug Info
  Drug Type Small molecule Small molecule
  Therapeutic Class Antifungal Agents Antifungal Agents
  Structure

 Mechanism of Amphotericin B (lipid complex)-Miconazole Interaction (Severity Level: Minor)
     Attenuated pharmacological effects (Unspecific) Click to Show/Hide Mechanism Graph
      Drug Name Amphotericin B (lipid complex) Miconazole
      Mechanism Amphotericin B Reduce therapeutic efficacy of Amphotericin B
      Key Mechanism Factor 1
Factor Name Pharmacodynamics
Factor Description Reduced pharmacological effects leading to insufficient efficacy and/or treatment failure.
      Mechanism Description
  • Attenuated pharmacological effects of  Amphotericin B (lipid complex) when combined with Miconazole 

References
1 Saag MS, Powderly WG, Cloud GA, et al "Comparison of amphotericin B with fluconazole in the treatment of acute AIDS-associated cryptococcal meningitis." N Engl J Med 326 (1992): 83-9
2 Product Information. Fungizone (amphotericin B). Apothecon Inc, Plainsboro, NJ.
3 Product Information. Ambisome (amphotericin B liposomal) Nexstar Pharmaceuticals, San Dimas, CA.