Drug General Information (ID: D1057)
  Drug Name
Miconazole
  Drug Type Small molecule
  Drug Synonymous
Dactarin; MCZ; Miconazol; Miconazolo; Miconazolum; Micozole; Minostate; Monistat; Vusion; Zimycan; Daktarin IV; Miconasil Nitrate; Miconazole nitrate salt; Miconazolo [DCIT]; Monistat IV; MJR 1762; Miconazole 3; Miconazole 3 Combination Pack; Miconazole 7 Combination Pack; Monazole 7; Monistat 1 Combination Pack; Monistat 3 Vaginal Ovules; Monistat 5 Tampon; Monistat 7 Vaginal Suppositories; R 18134; Aflorix(nitrate); Albistat(nitrate); Andergin(nitrate); Conofite(nitrate); Daktarin (TN); Femizol (TN); Femizol-M; Florid(nitrate); Lotrimin AF(nitrate); Micantin (nitrate); Micatin (TN); Miconazex (TN); Miconazol [INN-Spanish]; Miconazole-7; Miconazolum [INN-Latin]; Monista (nitrate); Monistat (TN); Monistat 3 Dual-Pak; Monistat 7 Dual-Pak; Monistat Dual-PAK; Monistat iv (TN); Monistat-Derm; Novo-Miconazole Vaginal Ovules; Epi-Monistat(nitrate); Gyno-Daktar(nitrate); Monistat-Derm (TN); R-14,889; Miconazole (JP15/USP/INN); Miconazole [USAN:BAN:INN:JAN]; Imidazole, 1-(2-(2,4-dichlorophenyl)-2-((2,4-dichlorophenyl) methoxy)ethyl)-(9CI); Imidazole, 1-(2-(2,4-dichlorophenyl)-2-((2,4-dichlorophenyl)methoxy)ethyl)-(9CI); (+-)-1-(2,4-Dichloro-beta-((2,4-dichlorobenzyl)oxy)phenethyl)imidazole; 1-(2,4-Dichloro-beta-((2,4-dichlorobenzyl)oxy)phenethyl)imidazole; 1-(2,4-dichloro-beta-((2,4-dichlorobenzyl)oxy)phenethyl) imidazole; 1-[2,4-Dichloro-beta-([2,4-dichloro-benzyl]oxy)phenethyl]imidazole; 1-[2-(2,4-Dichlorophenyl)-2-[(2,4-dichlorophenyl)methoxy]ethyl]-1H-imidazole; 1-[2-(2,4-dichlorobenzyloxy)-2-(2,4-dichlorophenyl)ethyl]-1H-imidazole; 1-[2-(2,4-dichlorophenyl)-2-[(2,4-dichlorophenyl)methoxy]ethyl]imidazole; 1-[2-(2,4-dichlorophenyl)-2-{[(2,4-dichlorophenyl)methyl]oxy}ethyl]-1H-imidazole; 1-{2-[(2,4-dichlorobenzyl)oxy]-2-(2,4-dichlorophenyl)ethyl}-1H-imidazole
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  Disease Class 1F29-1F2F: Fungal infection
  Therapeutic Class Antifungal Agents
  Structure Could Not Find 2D Structure
3D Structure 2D Structure
  Formula C18H14Cl4N2O
  InChI 1S/C18H14Cl4N2O/c19-13-2-1-12(16(21)7-13)10-25-18(9-24-6-5-23-11-24)15-4-3-14(20)8-17(15)22/h1-8,11,18H,9-10H2
  InChIKey BYBLEWFAAKGYCD-UHFFFAOYSA-N
  Canonical SMILES C1=CC(=C(C=C1Cl)Cl)COC(CN2C=CN=C2)C3=C(C=C(C=C3)Cl)Cl
  External Link
Pubchem ID 4189
CAS Number 22916-47-8
CHEBI ID 82892
TTD ID D00AXJ
INTEDE ID DR1084
VARIDT ID DR00477

Drug-Drug Interaction Network
  Sunburst Graph
AM002  Affected cellular transport
AM004  Affected intra/extra-hepatic metabolism
AM007  Pharmacodynamic antagonistic effects
BM010  Transporter inhibition
BM017  CYP450 enzyme inhibition
BM022  CYP450 enzyme induction
BM107  Attenuated pharmacological effects (Unspecific)
  Relation Graph
 Full list of drugs interacting with Miconazole
      Affected cellular transport
   Transporter inhibition Drug Num:  1
Drug ID
 
Drug Name
Formula Pubchem ID Severity Level Interaction Detail REF
D0656
 
Fexofenadine
 
C32H39NO4
 
3348 
Minor    Inter Info   
[403], [404]
      Affected intra/extra-hepatic metabolism
   CYP450 enzyme inhibition Drug Num:  250
Drug ID
 
Drug Name
Formula Pubchem ID Severity Level Interaction Detail REF
D0013
 
Acetohexamide
 
C15H20N2O4S
 
1989 
Major    Inter Info   
[1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25]
D0115
 
Astemizole
 
C28H31FN4O
 
2247 
Major    Inter Info   
[26], [27], [28], [29], [30], [31], [32], [33], [34], [12], [35], [36], [16], [37], [17], [38], [39], [40], [41], [42], [43], [44], [24], [45], [46]
D0325
 
Chlorpropamide
 
C10H13ClN2O3S
 
2727 
Major    Inter Info   
[1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25]
D0481
 
Dicoumarol
 
C19H12O6
 
54676038 
Major    Inter Info   
[47], [48], [49]
D0727
 
Glimepiride
 
C24H34N4O5S
 
3476 
Major    Inter Info   
[1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25]
D0728
 
Glipizide
 
C21H27N5O4S
 
3478 
Major    Inter Info   
[1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25]
D0730
 
Glyburide
 
C23H28ClN3O5S
 
3488 
Major    Inter Info   
[1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25]
D0087
 
Anisindione
 
C16H12O3
 
2197 
Major    Inter Info   
[50], [51], [47], [52], [53], [54], [55], [9], [56], [57], [58], [59], [48], [60], [61], [49], [62]
D0559
 
Eliglustat
 
C23H36N2O4
 
23652731 
Major    Inter Info   
[63]
D1258
 
Pexidartinib
 
C20H15ClF3N5
 
25151352 
Major    Inter Info   
[64]
D1603
 
Tolbutamide
 
C12H18N2O3S
 
5505 
Major    Inter Info   
[1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25]
D1555
 
Terfenadine
 
C32H41NO2
 
5405 
Major    Inter Info   
[26], [27], [65], [28], [66], [30], [67], [33], [68], [69], [70], [71], [72], [73], [74], [75], [76], [34], [12], [36], [16], [77], [37], [17], [39], [42], [24], [46], [78], [79], [80]
D1601
 
Tolazamide
 
C14H21N3O3S
 
5503 
Major    Inter Info   
[1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25]
D1711
 
Warfarin
 
C19H16O4
 
54678486 
Major    Inter Info   
[50], [51], [47], [52], [53], [54], [55], [9], [56], [57], [58], [59], [48], [60], [61], [49], [62]
D0043
 
Alosetron
 
C17H18N4O
 
2099 
Moderate    Inter Info   
[81]
D0045
 
Alprazolam
 
C17H13ClN4
 
2118 
Moderate    Inter Info   
[82], [83], [84], [85], [30], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101]
D0068
 
Amitriptyline
 
C20H23N
 
2160 
Moderate    Inter Info   
[102], [103], [104], [105], [106]
D0069
 
Amlodipine
 
C20H25ClN2O5
 
2162 
Moderate    Inter Info   
[107], [108], [109], [16], [110], [111], [112], [113]
D0100
 
Aprepitant
 
C23H21F7N4O3
 
135413536 
Moderate    Inter Info   
[114], [115]
D0116
 
Atazanavir
 
C38H52N6O7
 
148192 
Moderate    Inter Info   
[116]
D0120
 
Atorvastatin
 
C33H35FN2O5
 
60823 
Moderate    Inter Info   
[51], [117], [118], [119], [120], [121], [122], [123], [124], [125], [9], [90]
D0194
 
Bosentan
 
C27H29N5O6S
 
104865 
Moderate    Inter Info   
[28], [51], [126]
D0219
 
Buprenorphine
 
C29H41NO4
 
644073 
Moderate    Inter Info   
[127]
D0222
 
Buspirone
 
C21H31N5O2
 
2477 
Moderate    Inter Info   
[128], [129]
D0223
 
Busulfan
 
C6H14O6S2
 
2478 
Moderate    Inter Info   
[51], [130]
D0226
 
Butorphanol
 
C21H29NO2
 
5361092 
Moderate    Inter Info   
[90]
D0255
 
Carbamazepine
 
C15H12N2O
 
2554 
Moderate    Inter Info   
[51], [130]
D0298
 
Celecoxib
 
C17H14F3N3O2S
 
2662 
Moderate    Inter Info   
[131]
D0303
 
Cerivastatin
 
C26H34FNO5
 
446156 
Moderate    Inter Info   
[51], [117], [118], [119], [120], [121], [122], [123], [124], [125], [9], [90]
D0338
 
Cinacalcet
 
C22H22F3N
 
156419 
Moderate    Inter Info   
[132]
D0342
 
Cisapride
 
C23H29ClFN3O4
 
6917698 
Moderate    Inter Info   
[133], [134], [135], [30], [136], [137], [138], [12], [90], [139]
D0386
 
Conivaptan
 
C32H26N4O2
 
151171 
Moderate    Inter Info   
[90]
D0387
 
Conjugated estrogens
 
C18H21NaO5S
 
45357473 
Moderate    Inter Info   
[140], [5], [141], [17], [142], [143]
D0388
 
Conjugated estrogens (topical)
 
C18H21NaO5S
 
45357473 
Moderate    Inter Info   
[5], [141], [143]
D0402
 
Cyclosporine
 
C62H111N11O12
 
5284373 
Moderate    Inter Info   
[90]
D0424
 
Darifenacin
 
C28H30N2O2
 
444031 
Moderate    Inter Info   
[144], [145]
D0473
 
Diazepam
 
C16H13ClN2O
 
3016 
Moderate    Inter Info   
[146], [147], [148], [12], [36], [16], [149], [150], [17]
D0476
 
Diclofenac
 
C14H11Cl2NO2
 
3033 
Moderate    Inter Info   
[28], [51], [151]
D0484
 
Dienestrol (topical)
 
C18H18O2
 
667476 
Moderate    Inter Info   
[5], [141], [143]
D0487
 
Diethylstilbestrol
 
C18H20O2
 
448537 
Moderate    Inter Info   
[140], [5], [141], [17], [142], [143]
D0494
 
Dihydroergotamine
 
C33H37N5O5
 
10531 
Moderate    Inter Info   
[152], [153], [154], [30], [155], [156], [157], [158], [159], [160], [161], [162], [163], [164], [90], [165], [166], [167], [168]
D0497
 
Diltiazem
 
C22H26N2O4S
 
39186 
Moderate    Inter Info   
[107], [108], [109], [16], [110], [111], [112], [113]
D0508
 
Disopyramide
 
C21H29N3O
 
3114 
Moderate    Inter Info   
[90]
D0513
 
Dofetilide
 
C19H27N3O5S2
 
71329 
Moderate    Inter Info   
[28], [51], [90], [169]
D0585
 
Eplerenone
 
C24H30O6
 
443872 
Moderate    Inter Info   
[90]
D0595
 
Erlotinib
 
C22H23N3O4
 
176870 
Moderate    Inter Info   
[170], [171]
D0606
 
Estradiol
 
C18H24O2
 
5757 
Moderate    Inter Info   
[140], [5], [141], [17], [142], [143]
D0607
 
Estradiol (topical)
 
C18H24O2
 
5757 
Moderate    Inter Info   
[5], [141], [143]
D0609
 
Estrone
 
C18H22O2
 
5870 
Moderate    Inter Info   
[140], [5], [141], [17], [142], [143]
D0612
 
Eszopiclone
 
C17H17ClN6O3
 
969472 
Moderate    Inter Info   
[172], [173], [174], [51], [30], [175], [176]
D0621
 
Ethotoin
 
C11H12N2O2
 
3292 
Moderate    Inter Info   
[177]
D0626
 
Etonogestrel
 
C22H28O2
 
6917715 
Moderate    Inter Info   
[140], [5], [141], [17], [142], [143]
D0640
 
Felodipine
 
C18H19Cl2NO4
 
3333 
Moderate    Inter Info   
[107], [108], [109], [16], [110], [111], [112], [113]
D0646
 
Fentanyl
 
C22H28N2O
 
3345 
Moderate    Inter Info   
[90]
D0667
 
Fluconazole
 
C13H12F2N6O
 
3365 
Moderate    Inter Info   
[178], [179], [180], [133], [181], [30], [182], [183], [184], [138], [185], [186], [12], [142], [187], [188], [189], [190]
D0673
 
Flunisolide (nasal)
 
C24H31FO6
 
82153 
Moderate    Inter Info   
[191], [192], [193]
D0674
 
Fluorometholone (ophthalmic)
 
C22H29FO4
 
9878 
Moderate    Inter Info   
[191], [192], [193]
D0687
 
Fluvoxamine
 
C15H21F3N2O2
 
5324346 
Moderate    Inter Info   
[194], [195]
D0713
 
Gefitinib
 
C22H24ClFN4O3
 
123631 
Moderate    Inter Info   
[170], [196]
D0740
 
Grepafloxacin
 
C19H22FN3O3
 
72474 
Moderate    Inter Info   
[197]
D0745
 
Guanfacine
 
C9H9Cl2N3O
 
3519 
Moderate    Inter Info   
[51], [198]
D0772
 
Hydrocodone
 
C18H21NO3
 
5284569 
Moderate    Inter Info   
[90]
D0774
 
Hydrocortisone (ophthalmic)
 
C21H30O5
 
5754 
Moderate    Inter Info   
[191], [192], [193]
D0793
 
Imatinib
 
C29H31N7O
 
5291 
Moderate    Inter Info   
[199]
D0795
 
Imipramine
 
C19H24N2
 
3696 
Moderate    Inter Info   
[102], [103], [104], [105], [106]
D0845
 
Irinotecan
 
C33H38N4O6
 
60838 
Moderate    Inter Info   
[200], [28], [51], [201], [202], [203], [204]
D0846
 
Irinotecan (liposomal)
 
C33H38N4O6
 
60838 
Moderate    Inter Info   
[28], [51], [201]
D0865
 
Isradipine
 
C19H21N3O5
 
3784 
Moderate    Inter Info   
[107], [108], [109], [16], [110], [111], [112], [113]
D0916
 
Levobupivacaine
 
C18H28N2O
 
92253 
Moderate    Inter Info   
[51], [205]
D0922
 
Levonorgestrel
 
C21H28O2
 
13109 
Moderate    Inter Info   
[140], [5], [141], [17], [142], [143]
D0955
 
Loteprednol (ophthalmic)
 
C21H27ClO5
 
9865442 
Moderate    Inter Info   
[191], [192], [193]
D0956
 
Lovastatin
 
C24H36O5
 
53232 
Moderate    Inter Info   
[51], [117], [118], [119], [120], [121], [122], [123], [124], [125], [9], [90]
D0990
 
Medroxyprogesterone acetate
 
C24H34O4
 
6279 
Moderate    Inter Info   
[5], [141], [143]
D1003
 
Mephenytoin
 
C12H14N2O2
 
4060 
Moderate    Inter Info   
[177]
D1017
 
Methadone
 
C21H27NO
 
4095 
Moderate    Inter Info   
[206], [207], [208], [209], [210], [211], [212], [213], [214], [215], [216], [217], [17], [218], [219], [220], [221], [222]
D1037
 
Methylergometrine
 
C20H25N3O2
 
8226 
Moderate    Inter Info   
[154], [162], [168]
D1043
 
Methysergide
 
C21H27N3O2
 
9681 
Moderate    Inter Info   
[154], [162], [168]
D0008
 
Acalabrutinib
 
C26H23N7O2
 
71226662 
Moderate    Inter Info   
[223], [145]
D0038
 
Aliskiren
 
C30H53N3O6
 
5493444 
Moderate    Inter Info   
[200], [51], [224], [225]
D0066
 
Amiodarone
 
C25H29I2NO3
 
2157 
Moderate    Inter Info   
[90]
D0096
 
Apixaban
 
C25H25N5O4
 
10182969 
Moderate    Inter Info   
[51], [226], [145]
D0105
 
Aripiprazole
 
C23H27Cl2N3O2
 
60795 
Moderate    Inter Info   
[227]
D0108
 
Artemether
 
C16H26O5
 
68911 
Moderate    Inter Info   
[90]
D0129
 
Avapritinib
 
C26H27FN10
 
118023034 
Moderate    Inter Info   
[51], [228]
D0133
 
Axitinib
 
C22H18N4OS
 
6450551 
Moderate    Inter Info   
[51], [229]
D0161
 
Benzhydrocodone
 
C25H25NO4
 
49836084 
Moderate    Inter Info   
[90]
D0192
 
Boceprevir
 
C27H45N5O5
 
10324367 
Moderate    Inter Info   
[230], [231]
D0195
 
Bosutinib
 
C26H29Cl2N5O3
 
5328940 
Moderate    Inter Info   
[51], [232]
D0204
 
Brigatinib
 
C29H39ClN7O2P
 
68165256 
Moderate    Inter Info   
[28], [51], [233]
D0215
 
Budesonide
 
C25H34O6
 
5281004 
Moderate    Inter Info   
[234], [28], [51], [235], [236], [237], [191], [238], [239], [240], [241], [242], [230], [231], [243], [244]
D0216
 
Budesonide (nasal)
 
C25H34O6
 
5281004 
Moderate    Inter Info   
[234], [28], [51]
D0227
 
Cabazitaxel
 
C45H57NO14
 
9854073 
Moderate    Inter Info   
[245]
D0230
 
Cabozantinib
 
C28H24FN3O5
 
25102847 
Moderate    Inter Info   
[246]
D0262
 
Cariprazine
 
C21H32Cl2N4O
 
11154555 
Moderate    Inter Info   
[247]
D0302
 
Ceritinib
 
C28H36ClN5O3S
 
57379345 
Moderate    Inter Info   
[248]
D0333
 
Ciclesonide
 
C32H44O7
 
6918155 
Moderate    Inter Info   
[249], [250], [251], [252]
D0334
 
Ciclesonide (nasal)
 
C32H44O7
 
6918155 
Moderate    Inter Info   
[253], [254], [251]
D0375
 
Cobicistat
 
C40H53N7O5S2
 
25151504 
Moderate    Inter Info   
[255]
D0376
 
Cobimetinib
 
C21H21F3IN3O2
 
16222096 
Moderate    Inter Info   
[256]
D0380
 
Colchicine
 
C22H25NO6
 
6167 
Moderate    Inter Info   
[90]
D0393
 
Crizotinib
 
C21H22Cl2FN5O
 
11626560 
Moderate    Inter Info   
[257]
D0413
 
Dalfopristin
 
C34H50N4O9S
 
6323289 
Moderate    Inter Info   
[258]
D0428
 
Dasatinib
 
C22H26ClN7O2S
 
3062316 
Moderate    Inter Info   
[90]
D0454
 
Dexamethasone (nasal)
 
C22H29FO5
 
5743 
Moderate    Inter Info   
[191], [192], [193]
D0455
 
Dexamethasone (ophthalmic)
 
C22H29FO5
 
5743 
Moderate    Inter Info   
[191], [192], [193]
D0511
 
Docetaxel
 
C43H53NO14
 
148124 
Moderate    Inter Info   
[259], [28], [51], [260], [261], [262], [263], [264], [265]
D0534
 
Dronedarone
 
C31H44N2O5S
 
208898 
Moderate    Inter Info   
[90]
D0536
 
Drospirenone
 
C24H30O3
 
68873 
Moderate    Inter Info   
[140], [5], [141], [17], [142], [143]
D0542
 
Dutasteride
 
C27H30F6N2O2
 
6918296 
Moderate    Inter Info   
[266]
D0577
 
Entrectinib
 
C31H34F2N6O2
 
25141092 
Moderate    Inter Info   
[267]
D0578
 
Enzalutamide
 
C21H16F4N4O2S
 
15951529 
Moderate    Inter Info   
[268]
D0592
 
Ergometrine
 
C19H23N3O2
 
443884 
Moderate    Inter Info   
[154], [162], [168]
D0605
 
Esterified estrogens
 
NA
 
NA
Moderate    Inter Info   
[140], [5], [141], [17], [142], [143]
D0610
 
Estrone sulfate
 
C18H22O5S
 
3001028 
Moderate    Inter Info   
[5], [141], [143]
D0611
 
Estrone sulfate (topical)
 
C18H22O5S
 
3001028 
Moderate    Inter Info   
[5], [141], [143]
D0629
 
Everolimus
 
C53H83NO14
 
6442177 
Moderate    Inter Info   
[90]
D0655
 
Fesoterodine
 
C26H37NO3
 
6918558 
Moderate    Inter Info   
[270]
D0665
 
Flibanserin
 
C20H21F3N4O
 
6918248 
Moderate    Inter Info   
[271]
D0697
 
Fosphenytoin
 
C16H15N2O6P
 
56339 
Moderate    Inter Info   
[177]
D0699
 
Fostamatinib
 
C23H26FN6O9P
 
11671467 
Moderate    Inter Info   
[272]
D0720
 
Gilteritinib
 
C29H44N8O3
 
49803313 
Moderate    Inter Info   
[51], [273]
D0725
 
Glasdegib
 
C21H22N6O
 
25166913 
Moderate    Inter Info   
[274]
D0739
 
Grazoprevir
 
C38H50N6O9S
 
44603531 
Moderate    Inter Info   
[275], [276]
D0749
 
Halofantrine
 
C26H30Cl2F3NO
 
37393 
Moderate    Inter Info   
[90]
D0785
 
Ibrutinib
 
C25H24N6O2
 
24821094 
Moderate    Inter Info   
[277], [145]
D0791
 
Iloperidone
 
C24H27FN2O4
 
71360 
Moderate    Inter Info   
[90]
D0852
 
Isavuconazonium
 
C35H35F2N8O5S+
 
6918606 
Moderate    Inter Info   
[148]
D0866
 
Istradefylline
 
C20H24N4O4
 
5311037 
Moderate    Inter Info   
[90]
D0869
 
Ivacaftor
 
C24H28N2O3
 
16220172 
Moderate    Inter Info   
[278], [279]
D0894
 
Lapatinib
 
C29H26ClFN4O4S
 
208908 
Moderate    Inter Info   
[280]
D0896
 
Larotrectinib
 
C21H22F2N6O2
 
46188928 
Moderate    Inter Info   
[28], [51], [281]
D0905
 
Lesinurad
 
C17H14BrN3O2S
 
53465279 
Moderate    Inter Info   
[282]
D0909
 
Levacetylmethadol
 
C23H31NO2
 
15130 
Moderate    Inter Info   
[90]
D0911
 
Levamlodipine
 
C20H25ClN2O5
 
9822750 
Moderate    Inter Info   
[107], [108], [109], [16], [110], [111], [112], [113]
D0944
 
Lomitapide
 
C39H37F6N3O2
 
9853053 
Moderate    Inter Info   
[90]
D0946
 
Lonafarnib
 
C27H31Br2ClN4O2
 
148195 
Moderate    Inter Info   
[90]
D0953
 
Lorlatinib
 
C21H19FN6O2
 
71731823 
Moderate    Inter Info   
[283]
D0959
 
Lumateperone
 
C24H28FN3O
 
21302490 
Moderate    Inter Info   
[284]
D0961
 
Lurasidone
 
C28H36N4O2S
 
213046 
Moderate    Inter Info   
[28], [51], [285], [145]
D0966
 
Macitentan
 
C19H20Br2N6O4S
 
16004692 
Moderate    Inter Info   
[286]
D1062
 
Midostaurin
 
C35H30N4O4
 
9829523 
Moderate    Inter Info   
[287], [288]
D1101
 
Naldemedine
 
C32H34N4O6
 
54732242 
Moderate    Inter Info   
[51], [289]
D1117
 
Nefazodone
 
C25H32ClN5O2
 
4449 
Moderate    Inter Info   
[290]
D1134
 
Nifedipine
 
C17H18N2O6
 
4485 
Moderate    Inter Info   
[107], [108], [109], [16], [110], [111], [112], [113]
D1136
 
Nilotinib
 
C28H22F3N7O
 
644241 
Moderate    Inter Info   
[90]
D1157
 
Norgestrel
 
C21H28O2
 
13109 
Moderate    Inter Info   
[140], [5], [141], [17], [142], [143]
D1167
 
Olaparib
 
C24H23FN4O3
 
23725625 
Moderate    Inter Info   
[291]
D1169
 
Oliceridine
 
C22H30N2O2S
 
66553195 
Moderate    Inter Info   
[90]
D1190
 
Osimertinib
 
C28H33N7O2
 
71496458 
Moderate    Inter Info   
[292]
D1191
 
Ospemifene
 
C24H23ClO2
 
3036505 
Moderate    Inter Info   
[293]
D1212
 
Paclitaxel
 
C47H51NO14
 
36314 
Moderate    Inter Info   
[294], [295], [28], [296], [297], [298], [299], [263]
D1213
 
Paclitaxel (protein-bound)
 
C47H51NO14
 
36314 
Moderate    Inter Info   
[294], [295], [28]
D1214
 
Palbociclib
 
C24H29N7O2
 
5330286 
Moderate    Inter Info   
[51], [300]
D1221
 
Panobinostat
 
C21H23N3O2
 
6918837 
Moderate    Inter Info   
[301], [302]
D1232
 
Pazopanib
 
C21H23N7O2S
 
10113978 
Moderate    Inter Info   
[303]
D1290
 
Pimavanserin
 
C25H34FN3O2
 
10071196 
Moderate    Inter Info   
[304]
D1299
 
Pirfenidone
 
C12H11NO
 
40632 
Moderate    Inter Info   
[51], [305], [306]
D1306
 
Polatuzumab vedotin
 
NA
 
NA
Moderate    Inter Info   
[307]
D1313
 
Ponatinib
 
C29H27F3N6O
 
24826799 
Moderate    Inter Info   
[308]
D1368
 
Quetiapine
 
C21H25N3O2S
 
5002 
Moderate    Inter Info   
[309], [310], [311], [312], [313], [314], [315], [316], [317]
D1370
 
Quinestrol
 
C25H32O2
 
9046 
Moderate    Inter Info   
[140], [5], [141], [17], [142], [143]
D1398
 
Ribociclib
 
C23H30N8O
 
44631912 
Moderate    Inter Info   
[28], [51], [318]
D1409
 
Ripretinib
 
C24H21BrFN5O2
 
71584930 
Moderate    Inter Info   
[28], [319]
D1417
 
Rivaroxaban
 
C19H18ClN3O5S
 
9875401 
Moderate    Inter Info   
[28], [51], [320]
D1424
 
Romidepsin
 
C24H36N4O6S2
 
5352062 
Moderate    Inter Info   
[321], [17], [322]
D1444
 
Saquinavir
 
C38H50N6O5
 
441243 
Moderate    Inter Info   
[51], [130]
D1449
 
Saxagliptin
 
C18H25N3O2
 
11243969 
Moderate    Inter Info   
[51], [323]
D1466
 
Silodosin
 
C25H32F3N3O4
 
5312125 
Moderate    Inter Info   
[324]
D1491
 
Solifenacin
 
C23H26N2O2
 
154059 
Moderate    Inter Info   
[325]
D1496
 
Sonidegib
 
C26H26F3N3O3
 
24775005 
Moderate    Inter Info   
[326]
D1524
 
Suvorexant
 
C23H23ClN6O2
 
24965990 
Moderate    Inter Info   
[28], [327]
D1536
 
Tasimelteon
 
C15H19NO2
 
10220503 
Moderate    Inter Info   
[328]
D1541
 
Telaprevir
 
C36H53N7O6
 
3010818 
Moderate    Inter Info   
[230], [231]
D1549
 
Temsirolimus
 
C56H87NO16
 
6918289 
Moderate    Inter Info   
[329]
D1579
 
Ticagrelor
 
C23H28F2N6O4S
 
9871419 
Moderate    Inter Info   
[51], [330]
D1600
 
Tofacitinib
 
C16H20N6O
 
9926791 
Moderate    Inter Info   
[90]
D1608
 
Tolvaptan
 
C26H25ClN2O3
 
216237 
Moderate    Inter Info   
[90]
D1615
 
Trabectedin
 
C39H43N3O11S
 
108150 
Moderate    Inter Info   
[51], [331], [332]
D1663
 
Ubrogepant
 
C29H26F3N5O3
 
68748835 
Moderate    Inter Info   
[333]
D1666
 
Upadacitinib
 
C17H19F3N6O
 
58557659 
Moderate    Inter Info   
[90]
D1688
 
Venetoclax
 
C45H50ClN7O7S
 
49846579 
Moderate    Inter Info   
[28], [51], [334]
D1696
 
Vilazodone
 
C26H27N5O2
 
6918314 
Moderate    Inter Info   
[335]
D1718
 
Zanubrutinib
 
C27H29N5O3
 
135565884 
Moderate    Inter Info   
[336]
D1063
 
Mifepristone
 
C29H35NO2
 
55245 
Moderate    Inter Info   
[337], [338]
D1087
 
Montelukast
 
C35H36ClNO3S
 
5281040 
Moderate    Inter Info   
[339], [340]
D1112
 
Nateglinide
 
C19H27NO3
 
5311309 
Moderate    Inter Info   
[51], [6], [341], [342], [343]
D1119
 
Nelfinavir
 
C32H45N3O4S
 
64143 
Moderate    Inter Info   
[344]
D1130
 
Nicardipine
 
C26H29N3O6
 
4474 
Moderate    Inter Info   
[107], [108], [109], [16], [110], [111], [112], [113]
D1138
 
Nimodipine
 
C21H26N2O7
 
4497 
Moderate    Inter Info   
[107], [108], [109], [16], [110], [111], [112], [113]
D1141
 
Nisoldipine
 
C20H24N2O6
 
4499 
Moderate    Inter Info   
[90]
D1154
 
Norethisterone
 
C20H26O2
 
6230 
Moderate    Inter Info   
[5], [141], [143]
D1158
 
Nortriptyline
 
C19H21N
 
4543 
Moderate    Inter Info   
[102], [103], [104], [105], [106]
D1226
 
Paricalcitol
 
C27H44O3
 
5281104 
Moderate    Inter Info   
[51], [345]
D1283
 
Phenytoin
 
C15H12N2O2
 
1775 
Moderate    Inter Info   
[177]
D1292
 
Pimozide
 
C28H29F2N3O
 
16362 
Moderate    Inter Info   
[30], [346], [347], [348], [90]
D1333
 
Prednisolone (ophthalmic)
 
C21H28O5
 
5755 
Moderate    Inter Info   
[191], [192], [193]
D1348
 
Progesterone
 
C21H30O2
 
5994 
Moderate    Inter Info   
[140], [5], [141], [17], [142], [143]
D1349
 
Progesterone (topical)
 
C21H30O2
 
5994 
Moderate    Inter Info   
[5], [141], [143]
D1371
 
Quinidine
 
C20H24N2O2
 
441074 
Moderate    Inter Info   
[28], [51], [90], [349]
D1372
 
Quinine
 
C20H24N2O2
 
3034034 
Moderate    Inter Info   
[28], [51], [350], [351], [352], [353], [354], [355], [356], [357], [358]
D1378
 
Ramelteon
 
C16H21NO2
 
208902 
Moderate    Inter Info   
[359]
D1383
 
Ranolazine
 
C24H33N3O4
 
56959 
Moderate    Inter Info   
[90]
D1392
 
Repaglinide
 
C27H36N2O4
 
65981 
Moderate    Inter Info   
[360], [361], [362], [363], [364], [365], [366]
D1440
 
Salmeterol
 
C25H37NO4
 
5152 
Moderate    Inter Info   
[90]
D1465
 
Sildenafil
 
C22H30N6O4S
 
135398744 
Moderate    Inter Info   
[90]
D1473
 
Simvastatin
 
C25H38O5
 
54454 
Moderate    Inter Info   
[51], [117], [118], [119], [120], [121], [122], [123], [124], [125], [9], [90]
D1512
 
Sufentanil
 
C22H30N2O2S
 
41693 
Moderate    Inter Info   
[367], [368], [369]
D1526
 
Tacrolimus
 
C44H69NO12
 
445643 
Moderate    Inter Info   
[90]
D1527
 
Tadalafil
 
C22H19N3O4
 
110635 
Moderate    Inter Info   
[28], [370], [371], [149]
D1534
 
Tamsulosin
 
C20H28N2O5S
 
129211 
Moderate    Inter Info   
[372], [373], [374], [306]
D1592
 
Tipranavir
 
C31H33F3N2O5S
 
54682461 
Moderate    Inter Info   
[375]
D1607
 
Tolterodine
 
C22H31NO
 
443879 
Moderate    Inter Info   
[376], [377]
D1611
 
Torasemide
 
C16H20N4O3S
 
41781 
Moderate    Inter Info   
[378], [379], [380]
D1612
 
Toremifene
 
C26H28ClNO
 
3005573 
Moderate    Inter Info   
[381]
D1624
 
Trazodone
 
C19H22ClN5O
 
5533 
Moderate    Inter Info   
[51], [130]
D1629
 
Triamcinolone (nasal)
 
C21H27FO6
 
31307 
Moderate    Inter Info   
[191], [192], [193]
D1630
 
Triamcinolone (ophthalmic)
 
C21H27FO6
 
31307 
Moderate    Inter Info   
[191], [192], [193]
D1632
 
Triazolam
 
C17H12Cl2N4
 
5556 
Moderate    Inter Info   
[82], [83], [84], [85], [30], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101]
D1674
 
Valdecoxib
 
C16H14N2O3S
 
119607 
Moderate    Inter Info   
[382]
D1682
 
Vardenafil
 
C23H32N6O4S
 
135400189 
Moderate    Inter Info   
[383], [145]
D1689
 
Venlafaxine
 
C17H27NO2
 
5656 
Moderate    Inter Info   
[28], [51], [384]
D1690
 
Verapamil
 
C27H38N2O4
 
2520 
Moderate    Inter Info   
[107], [108], [109], [16], [110], [111], [112], [113]
D1697
 
Vinblastine
 
C46H58N4O9
 
13342 
Moderate    Inter Info   
[90]
D1698
 
Vincristine
 
C46H56N4O10
 
5978 
Moderate    Inter Info   
[90]
D1699
 
Vincristine (liposome)
 
C46H56N4O10
 
5978 
Moderate    Inter Info   
[90]
D1700
 
Vinorelbine
 
C45H54N4O8
 
5311497 
Moderate    Inter Info   
[90]
D1706
 
Voriconazole
 
C16H14F3N5O
 
71616 
Moderate    Inter Info   
[28], [51], [17]
D1729
 
Zolpidem
 
C19H21N3O
 
5732 
Moderate    Inter Info   
[385], [386], [387], [388], [389], [390], [391]
D1730
 
Zonisamide
 
C8H8N2O3S
 
5734 
Moderate    Inter Info   
[392], [393]
D0080
 
Amprenavir
 
C25H35N3O6S
 
65016 
Minor    Inter Info   
[397]
D0345
 
Citalopram
 
C20H21FN2O
 
2771 
Minor    Inter Info   
[398], [399]
D0516
 
Donepezil
 
C24H29NO3
 
3152 
Minor    Inter Info   
[400], [306], [401], [402]
D0950
 
Loratadine
 
C22H23ClN2O2
 
3957 
Minor    Inter Info   
[405], [406], [407], [408]
D0053
 
Ambrisentan
 
C22H22N2O4
 
6918493 
Minor    Inter Info   
[409]
D0106
 
Armodafinil
 
C15H15NO2S
 
9690109 
Minor    Inter Info   
[28], [410], [411]
D0425
 
Darolutamide
 
C19H19ClN6O2
 
67171867 
Minor    Inter Info   
[412]
D0515
 
Dolutegravir
 
C20H19F2N3O5
 
54726191 
Minor    Inter Info   
[413]
D0599
 
Escitalopram
 
C20H21FN2O
 
146570 
Minor    Inter Info   
[398], [399]
D0797
 
Indacaterol
 
C24H28N2O3
 
6918554 
Minor    Inter Info   
[414]
D1074
 
Mirabegron
 
C21H24N4O2S
 
9865528 
Minor    Inter Info   
[415]
D1394
 
Retapamulin (topical)
 
C30H47NO4S
 
6918462 
Minor    Inter Info   
[416]
D1434
 
Ruxolitinib
 
C17H18N6
 
25126798 
Minor    Inter Info   
[51], [417]
D1664
 
Ulipristal
 
C28H35NO3
 
13559281 
Minor    Inter Info   
[51], [418]
D1081
 
Modafinil
 
C15H15NO2S
 
4236 
Minor    Inter Info   
[28], [410], [411]
D1291
 
Pimecrolimus (topical)
 
C43H68ClNO11
 
6509979 
Minor    Inter Info   
[419]
D1399
 
Rifabutin
 
C46H62N4O11
 
135398743 
Minor    Inter Info   
[51], [420], [90]
D1415
 
Ritonavir
 
C37H48N6O5S2
 
392622 
Minor    Inter Info   
[421], [422]
D1428
 
Ropivacaine
 
C17H26N2O
 
175805 
Minor    Inter Info   
[423], [424], [425], [426], [427], [428], [429]
D1464
 
Sibutramine
 
C17H26ClN
 
5210 
Minor    Inter Info   
[430]
D1726
 
Ziprasidone
 
C21H21ClN4OS
 
60854 
Minor    Inter Info   
[431], [432], [433], [434]
   CYP450 enzyme induction Drug Num:  1
Drug ID
 
Drug Name
Formula Pubchem ID Severity Level Interaction Detail REF
D0628
 
Etravirine
 
C20H15BrN6O
 
193962 
Moderate    Inter Info   
[269]
      Pharmacodynamic antagonistic effects
   Attenuated pharmacological effects (Unspecific) Drug Num:  4
Drug ID
 
Drug Name
Formula Pubchem ID Severity Level Interaction Detail REF
D0075
 
Amphotericin B
 
C47H73NO17
 
5280965 
Minor    Inter Info   
[394], [395], [396]
D0076
 
Amphotericin B (cholesteryl sulfate)
 
C47H73NO17
 
5280965 
Minor    Inter Info   
[394], [395], [396]
D0077
 
Amphotericin B (lipid complex)
 
C47H73NO17
 
5280965 
Minor    Inter Info   
[394], [395], [396]
D0078
 
Amphotericin B (liposomal)
 
C47H73NO17
 
5280965 
Minor    Inter Info   
[394], [395], [396]
References
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35 Product Information. Hismanal (astemizole). Janssen Pharmaceutica, Titusville, NJ.
36 Product Information. Nizoral (ketoconazole). Janssen Pharmaceutica, Titusville, NJ. (1992):.
37 Product Information. Sporonox (itraconazole). Janssen Pharmaceutica, Titusville, NJ.
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63 Product Information. Cerdelga (eliglustat). Genzyme Corporation, Cambridge, MA.
64 Product Information. Turalio (pexidartinib). Daiichi Sankyo, Inc., Parsippany, NJ.
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77 Product Information. Seldane (terfenadine). Hoechst Marion-Roussel Inc, Kansas City, MO.
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81 Product Information. Lotronex (alosetron). Glaxo Wellcome, Research Triangle Park, NC.
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89 Product Information. Halcion (triazolam). Pharmacia and Upjohn, Kalamazoo, MI.
90 Product Information. ORAVIG (miconazole). Strativa Pharmaceuticals, a Division of Par Pharmaceuticals, Inc., Woodcliff Lake, NJ.
91 Product Information. Xanax (alprazolam). Pharmacia and Upjohn, Kalamazoo, MI.
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114 Product Information. Emend (aprepitant). Merck & Company Inc, West Point, PA.
115 Product Information. Emend for Injection (fosaprepitant). Merck & Company Inc, West Point, PA.
116 Product Information. Reyataz (atazanavir). Bristol-Myers Squibb, Princeton, NJ.
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126 Product Information. Tracleer (bosentan). Acetelion Pharmaceuticals US, Inc, South San Francisco, CA.
127 Product Information. Buprenex (buprenorphine). Reckitt and Colman Pharmaceutical, Richmond, VA.
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130 Multum Information Services, Inc. Expert Review Panel.
131 Product Information. Celebrex (celecoxib). Searle, Chicago, IL.
132 Product Information. Sensipar (cinacalcet). Amgen USA, Thousand Oaks, CA.
133 Bedford TA, Rowbotham DJ "Cisapride: drug interactions of clinical significance." Drug Saf 15 (1996): 167-75. [PMID: 8879971]
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139 Product Information. Propulsid (cisapride). Janssen Pharmaceutica, Titusville, NJ.
140 Devenport MH, Crook D, Wynn V, Lees LJ "Metabolic effects of low-dose fluconazole in healthy female users and non-users of oral contraceptives." Br J Clin Pharmacol 27 (1989): 851-9. [PMID: 2547410]
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143 Weisberg E "Interactions between oral contraceptives and antifungals antibacterials - Is contraceptive failure the result?." Clin Pharmacokinet 36 (1999): 309-13. [PMID: 10384856]
144 Product Information. Enablex (darifenacin). Novartis Pharmaceuticals, East Hanover, NJ.
145 Product Information. Qelbree (viloxazine). Supernus Pharmaceuticals Inc, Rockville, MD.
146 Ahonen J, Olkkola KT, Neuvonen PJ "The effect of the antimycotic itraconazole on the pharmacokinetics and pharmacodynamics of diazepam." Fundam Clin Pharmacol 10 (1996): 314-8. [PMID: 8836707]
147 Andersson T, Miners JO, Veronese ME, Birkett DJ "Diazepam metabolism by human liver microsomes is mediated by both S-mephenytoin hydroxylase and CYP3A isoforms." Br J Clin Pharmacol 38(2) (1994): 131-7. [PMID: 7981013]
148 Product Information. Cresemba (isavuconazonium). Astellas Pharma US, Inc, Deerfield, IL.
149 Product Information. Sporanox (itraconazole). Janssen Pharmaceutica, Titusville, NJ.
150 Product Information. Valium (diazepam). Roche Laboratories, Nutley, NJ.
151 Product Information. Arthrotec (diclofenac-misoprostol). Searle, Skokie, IL.
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163 Product Information. D.H.E. 45 (dihydroergotamine). Sandoz Pharmaceuticals Corporation, East Hanover, NJ.
164 Product Information. Migranal (dihydroergotamine nasal). Novartis Pharmaceuticals, East Hanover, NJ.
165 Rosenthal E, Sala F, Chichmanian RM, Batt M, Cassuto JP "Ergotism related to concurrent administration of ergotamine tartrate and indinavir." JAMA 281 (1999): 987. [PMID: 10086430]
166 Spiegel M, Schmidauer C, Kampfl A, Sarcletti M, Poewe W "Cerebral ergotism under treatment with ergotamine and ritonavir." Neurology 57 (2001): 743-4. [PMID: 11524501]
167 Srisuma S, Lavonas EJ, Wananukul W "Ergotism and factitious hypotension associated with interaction of ergotamine with CYP3A4 inhibitors." Clin Toxicol (Phila) (2014): 1-4. [PMID: 24978905]
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169 Product Information. Tikosyn (dofetilide) Pfizer US Pharmaceuticals, Atlanta, GA.
170 Li J, Zhao M, He P, Hidalgo M, Baker SD "Differential metabolism of gefitinib and erlotinib by human cytochrome p450 enzymes." Clin Cancer Res 13 (2007): 3731-7. [PMID: 17575239]
171 Product Information. Tarceva (erlotinib). Genentech, South San Francisco, CA.
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175 Product Information. Imovane (zopiclone). Rhone-Poulenc Rorer Canada Inc, Laval, IN.
176 Product Information. Lunesta (eszopiclone). Sepracor Inc, Marlborough, MA.
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196 Product Information. Iressa (gefitinib). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
197 Product Information. Raxar (grepafloxacin). Glaxo Wellcome, Research Triangle Park, NC.
198 Product Information. Intuniv (guanfacine). Shire US Inc, Florence, KY.
199 Product Information. Gleevec (imatinib mesylate). Novartis Pharmaceuticals, East Hanover, NJ.
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224 Product Information. Tekturna (aliskiren). Novartis Pharmaceuticals, East Hanover, NJ.
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227 Product Information. Abilify (aripiprazole). Bristol-Myers Squibb, Princeton, NJ.
228 Product Information. Ayvakit (avapritinib). Blueprint Medicines Corporation, Cambridge, MA.
229 Product Information. Inlyta (axitinib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
230 Product Information. Incivek (telaprevir). Vertex Pharmaceuticals, Cambridge, MA.
231 Product Information. Victrelis (boceprevir). Schering-Plough Corporation, Kenilworth, NJ.
232 Product Information. Bosulif (bosutinib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
233 Product Information. Alunbrig (brigatinib). Ariad Pharmaceuticals Inc, Cambridge, MA.
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246 Product Information. Cometriq (cabozantinib). Exelixis Inc, S San Francisco, CA.
247 Product Information. Vraylar (cariprazine). Actavis Pharma, Inc., Parsippany, NJ.
248 Product Information. Zykadia (ceritinib). Novartis Pharmaceuticals, East Hanover, NJ.
249 Agencia Espaola de Medicamentos y Productos Sanitarios Healthcare "Centro de informacion online de medicamentos de la AEMPS - CIMA.".
250 EMEA. European Medicines Agency "EPARs. European Union Public Assessment Reports.".
251 Product Information. Alvesco (ciclesonide). Nycomed USA, Florham Park, NJ.
252 Product Information. Omnaris (ciclesonide nasal). Sepracor Inc, Marlborough, MA.
253 Agencia Espaola de Medicamentos y Productos Sanitarios Healthcare "Centro de informacion online de medicamentos de la AEMPS - CIMA.".
254 EMEA. European Medicines Agency "EPARs. European Union Public Assessment Reports.".
255 Product Information. Stribild (cobicistat/elvitegravir/emtricitabine/tenofov). Gilead Sciences, Foster City, CA.
256 Product Information. Cotellic (cobimetinib). Genentech, South San Francisco, CA.
257 Product Information. Xalkori (crizotinib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
258 Product Information. Synercid (dalfopristin-quinupristin) Rhone-Poulenc Rorer, Collegeville, PA.
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266 Product Information. Duagen (dutasteride). GlaxoSmithKline Healthcare, Pittsburgh, PA.
267 Product Information. Rozlytrek (entrectinib). Genentech, South San Francisco, CA.
268 Product Information. Xtandi (enzalutamide). Astellas Pharma US, Inc, Deerfield, IL.
269 Product Information. Intelence (etravirine). Ortho Biotech Inc, Bridgewater, NJ.
270 Product Information. Toviaz (fesoterodine). Pfizer U.S. Pharmaceuticals Group, New York, NY.
271 Product Information. Addyi (flibanserin). Sprout Pharmaceuticals, Raleigh, NC.
272 Product Information. Tavalisse (fostamatinib). Rigel Pharmaceuticals, South San Francisco, CA.
273 Product Information. Xospata (gilteritinib). Astellas Pharma US, Inc, Deerfield, IL.
274 Product Information. Daurismo (glasdegib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
275 Product Information. Accolate (zafirlukast). Zeneca Pharmaceuticals, Wilmington, DE.
276 Product Information. Zepatier (elbasvir-grazoprevir). Merck &amp Company Inc, Whitehouse Station, NJ.
277 Product Information. Imbruvica (ibrutinib). Pharmacyclics Inc, Sunnyvale, CA.
278 Product Information. Kalydeco (ivacaftor). Vertex Pharmaceuticals, Cambridge, MA.
279 Product Information. Orkambi (ivacaftor-lumacaftor). Vertex Pharmaceuticals, Cambridge, MA.
280 Product Information. Tykerb (lapatinib). Novartis Pharmaceuticals, East Hanover, NJ.
281 Product Information. Vitrakvi (larotrectinib). Bayer Pharmaceutical Inc, West Haven, CT.
282 Product Information. Zurampic (lesinurad). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
283 Product Information. Lorbrena (lorlatinib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
284 Product Information. Caplyta (lumateperone). Intra-Cellular Therapies, Inc., New York, NY.
285 Product Information. Latuda (lurasidone). Sunovion Pharmaceuticals Inc, Marlborough, MA.
286 Product Information. Opsumit (macitentan). Actelion Pharmaceuticals US Inc, South San Francisco, CA.
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289 Product Information. Symproic (naldemedine). Shionogi USA Inc, Florham Park, NJ.
290 Product Information. Serzone (nefazodone). Bristol-Myers Squibb, Princeton, NJ.
291 Product Information. Lynparza (olaparib). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
292 Product Information. Tagrisso (osimertinib). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
293 Product Information. Osphena (ospemifene). Shionogi USA Inc, Florham Park, NJ.
294 Bergmann TK, Filppula AM, Launiainen T, Nielsen F, Backman J, Brosen K "Neurotoxicity and low paclitaxel clearance associated with concomitant clopidogrel therapy in a 60 year old Caucasian woman with ovarian carcinoma." Br J Clin Pharmacol (2015):. [PMID: 26446447]
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297 Product Information. Abraxane (paclitaxel protein-bound). American Pharmaceutical Partners, Schaumberg, IL.
298 Product Information. Taxol (paclitaxel). Bristol-Myers Squibb, Princeton, NJ.
299 Spencer CM, Faulds D "Paclitaxel. A review of its pharmacodynamic and pharmacokinetic properties and therapeutic potential in the treatment of cancer." Drugs 48 (1994): 794-847. [PMID: 7530632]
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301 Hamberg P, Woo MM, Chen LC, et al. "Effect of ketoconazole-mediated CYP3A4 inhibition on clinical pharmacokinetics of panobinostat (LBH589), an orally active histone deacetylase inhibitor." Cancer Chemother Pharmacol 68 (2011): 805-13. [PMID: 21706316]
302 Product Information. Farydak (panobinostat). Novartis Pharmaceuticals, East Hanover, NJ.
303 Product Information. Votrient (pazopanib). GlaxoSmithKline, Research Triangle Park, NC.
304 Product Information. Nuplazid (pimavanserin). Accelis Pharma, East Windsor, NJ.
305 Product Information. Esbriet (pirfenidone). Intermune Inc, Brisbane, CA.
306 Product Information. Varubi (rolapitant). Tesaro Inc., Waltham, MA.
307 Product Information. Polivy (polatuzumab vedotin). Genentech, South San Francisco, CA.
308 Product Information. Iclusig (ponatinib). Ariad Pharmaceuticals Inc, Cambridge, MA.
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313 Quetiapine for schizophrenia. Med Lett Drugs Ther 39 (1997): 117-8. [PMID: 9422044]
314 Spina E, de Leon J "Metabolic drug interactions with newer antipsychotics: a comparative review." Basic Clin Pharmacol Toxicol 100 (2007): 4-22. [PMID: 17214606]
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318 Product Information. Kisqali (ribociclib). Novartis Pharmaceuticals, East Hanover, NJ.
319 Product Information. Qinlock (ripretinib). Deciphera Pharmaceuticals, Waltham, MA.
320 Product Information. Xarelto (rivaroxaban). Bayer Inc, Toronto, IA.
321 Product Information. Istodax (romidepsin). Gloucester Pharmaceuticals, Cambridge, MA.
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324 Product Information. Rapaflo (silodosin). Watson Pharmaceuticals, Corona, CA.
325 Product Information. VESIcare (solifenacin). GlaxoSmithKline, Research Triangle Park, NC.
326 Product Information. Odomzo (sonidegib). Novartis Pharmaceuticals, East Hanover, NJ.
327 Product Information. Belsomra (suvorexant). Merck & Company Inc, Whitehouse Station, NJ.
328 Product Information. Hetlioz (tasimelteon). Vanda Pharmaceuticals Inc, Rockville, MD.
329 Product Information. Torisel (temsirolimus). Wyeth-Ayerst Laboratories, Philadelphia, PA.
330 Product Information. Brilinta (ticagrelor). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
331 Machiels JP, Staddon A, Herremans C, et al. "Impact of cytochrome P450 3A4 inducer and inhibitor on the pharmacokinetics of trabectedin in patients with advanced malignancies: open-label, multicenter studies." Cancer Chemother Pharmacol 74 (2014): 729-37. [PMID: 25100135]
332 Product Information. Yondelis (trabectedin). Janssen Pharmaceuticals, Titusville, NJ.
333 Product Information. Ubrelvy (ubrogepant). Allergan Inc, Irvine, CA.
334 Product Information. Venclexta (venetoclax). AbbVie US LLC, North Chicago, IL.
335 Product Information. Viibryd (vilazodone). Trovis Pharmaceuticals LLC, New Haven, CT.
336 Product Information. Brukinsa (zanubrutinib). BeiGene USA, Inc, San Mateo, CA.
337 Product Information. Korlym (mifepristone). Corcept Therapeutics Incorporated, Menlo Park, CA.
338 Product Information. Mifeprex (mifepristone) Danco Laboratories, New York, NY.
339 Karonen T, Filppula A, Laitila J, Niemi M, Neuvonen PJ, Backman JT "Gemfibrozil Markedly Increases the Plasma Concentrations of Montelukast: A Previously Unrecognized Role for CYP2C8 in the Metabolism of Montelukast." Clin Pharmacol Ther (2010):. [PMID: 20592724]
340 Product Information. Singulair (montelukast). Merck & Co, Inc, West Point, PA.
341 Niemi M, Backman JT, Juntti-Patinen L, Neuvonen M, Neuvonen PJ "Coadministration of gemfibrozil and itraconazole has only a minor effect on the pharmacokinetics of the CYP2C9 and CYP3A4 substrate nateglinide." Br J Clin Pharmacol 60 (2005): 208-17. [PMID: 16042675]
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343 Product Information. Starlix (nateglinide) Novartis Pharmaceuticals, East Hanover, NJ.
344 Product Information. Viracept (nelfinavir). Agouron Pharma Inc, La Jolla, CA.
345 Product Information. Zemplar (paricalcitol). Abbott Pharmaceutical, Abbott Park, IL.
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348 Product Information. Orap Tablets (pimozide). Gate Pharmaceuticals, Sellersville, PA.
349 Product Information. QuiNIDine Gluconate ER (quiNIDine). GSMS, Incorporated, Camarillo, CA.
350 Mirghani RA, Ericsson O, Tybring G, Gustafsson LL, Bertilsson L "Quinine 3-hydroxylation as a biomarker reaction for the activity of CYP3A4 in man." Eur J Clin Pharmacol 59 (2003): 23-8. [PMID: 12743670]
351 Mirghani RA, Hellgren U, Bertilsson L, Gustafsson LL, Ericsson O "Metabolism and elimination of quinine in healthy volunteers." Eur J Clin Pharmacol (2003):. [PMID: 12920491]
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354 Product Information. Qualaquin (quinine). AR Scientific Inc, Philadelphia, PA.
355 Wanwimolruk S, Paine MF, Pusek SN, Watkins PB "Is quinine a suitable probe to assess the hepatic drug-metabolizing enzyme CYP3A4?" Br J Clin Pharmacol 54 (2002): 643-51. [PMID: 12492613]
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357 Zhao XJ, Ishizaki T "A further interaction study of quinine with clinically important drugs by human liver microsomes: determinations of inhibition constant (K-i) and type of inhibition." Eur J Drug Metab Pharm 24 (1999): 272-8. [PMID: 10716067]
358 Zhao XJ, Ishizaki T "Metabolic interactions of selected antimalarial and non-antimalarial drugs with the major pathway (3-hydroxylation) of quinine in human liver microsomes." Br J Clin Pharmacol 44 (1997): 505-11. [PMID: 9384469]
359 Product Information. Rozerem (ramelteon). Takeda Pharmaceuticals America, Lincolnshire, IL.
360 Bidstrup TB, Bjornsdottir I, Sidelmann UG, Thomsen MS, Hansen KT "CYP2C8 and CYP3A4 are the principal enzymes involved in the human in vitro biotransformation of the insulin secretagogue repaglinide." Br J Clin Pharmacol 56 (2003): 305-14. [PMID: 12919179]
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364 Product Information. Prandin (repaglinide). Novo Nordisk Pharmaceuticals Inc, Princeton, NJ.
365 Tornio A, Niemi M, Neuvonen M, et al. "The effect of gemfibrozil on repaglinide pharmacokinetics persists for at least 12 h after the dose: evidence for mechanism-based inhibition of CYP2C8 in vivo." Clin Pharmacol Ther 84 (2008): 403-11. [PMID: 18388877]
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370 Product Information. Adcirca (tadalafil). United Therapeutics Corporation, Silver Spring, MD.
371 Product Information. Cialis (tadalafil). Lilly, Eli and Company, Indianapolis, IN.
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375 Product Information. Aptivus (tipranavir). Boehringer-Ingelheim, Ridgefield, CT.
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381 Product Information. Fareston (toremifene). Schering Laboratories, Kenilworth, NJ.
382 Product Information. Bextra (valdecoxib). Pharmacia Corporation, Peapack, NJ.
383 Product Information. Levitra (vardenafil). Bayer, West Haven, CT.
384 Product Information. Effexor (venlafaxine). Wyeth-Ayerst Laboratories, Philadelphia, PA.
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389 Product Information. Ambien (zolpidem). sanofi-aventis, Bridgewater, NJ.
390 Product Information. Norvir (ritonavir). Abbott Pharmaceutical, Abbott Park, IL.
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395 Product Information. Fungizone (amphotericin B). Apothecon Inc, Plainsboro, NJ.
396 Product Information. Ambisome (amphotericin B liposomal) Nexstar Pharmaceuticals, San Dimas, CA.
397 Product Information. Agenerase (amprenavir). Glaxo Wellcome, Research Triangle Pk, NC.
398 Product Information. Celexa (citalopram). Forest Pharmaceuticals, St. Louis, MO.
399 Product Information. Lexapro (escitalopram). Forest Pharmaceuticals, St. Louis, MO.
400 Product Information. Aricept (donepezil). Pfizer US Pharmaceuticals, New York, NY.
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404 Product Information. Allegra-D (fexofenadine-pseudoephedrine). Chattem Consumer Products, Chattanooga, TN.
405 Product Information. Claritin (loratadine). Schering Laboratories, Kenilworth, NJ.
406 Product Information. Nizoral (ketoconazole). Janssen Pharmaceutica, Titusville, NJ.
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409 Product Information. Letairis (ambrisentan). Gilead Sciences, Foster City, CA.
410 Product Information. Nuvigil (armodafinil). Cephalon Inc, West Chester, PA.
411 Product Information. Provigil (modafinil). Cephalon, Inc, West Chester, PA.
412 Product Information. Nubeqa (darolutamide). Bayer HealthCare Pharmaceuticals Inc., Whippany, NJ.
413 Product Information. Tivicay (dolutegravir). ViiV Healthcare, Research Triangle Park, NC.
414 Product Information. Arcapta Neohaler (indacaterol). Novartis Pharmaceuticals, East Hanover, NJ.
415 Product Information. Myrbetriq (mirabegron). Astellas Pharma US, Inc, Deerfield, IL.
416 Product Information. Altabax (retapamulin topical). GlaxoSmithKline, Research Triangle Park, NC.
417 Product Information. Jakafi (ruxolitinib). Incyte Corporation, Wilmington, DE.
418 Product Information. ella (ulipristal). Afaxys Inc., Charleston, SC.
419 Product Information. Elidel (pimecrolimus topical). Novartis Pharmaceuticals, East Hanover, NJ.
420 Product Information. Mycobutin (rifabutin). Pharmacia and Upjohn, Kalamazoo, MI.
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428 Product Information. Naropin (ropivacaine). Astra USA, Westborough, MA.
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430 Product Information. Meridia (sibutramine). Knoll Pharmaceutical Company, Whippany, NJ.
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432 Product Information. Geodon (ziprasidone). Pfizer US Pharmaceuticals, New York, NY.
433 Wilner KD, Hansen RA, Folger CJ, Geoffroy P "The pharmacokinetics of ziprasidone in healthy volunteers treated with cimetidine or antacid." Br J Clin Pharmacol 49(Suppl 1) (2000): 57S-60S. [PMID: 10771455]
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