Drug General Information (ID: DDI2J09B71)
Drug Name			Amphotericin B (lipid complex)		Drug Info		Streptomycin		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antifungal Agents				Antibiotics
Structure

Mechanism of Amphotericin B (lipid complex)-Streptomycin Interaction (Severity Level: Moderate)
Increased risk of nephrotoxicity Click to Show/Hide Mechanism Graph
Drug Name		Amphotericin B (lipid complex)				Streptomycin
Mechanism		Nephrotoxicity				Nephrotoxicity
Key Mechanism Factor 1
		Factor Name		Nephrotoxicity
		Factor Description		The combination of drugs that can induce nephrotoxicity may increase the risk of kidney injury. When kidney injury occurs, the inability to remove excess urine and waste from the body can lead to high levels of urea nitrogen, creatinine, and electrolytes (such as potassium and magnesium) in the blood.
Mechanism Description		Increased risk of nephrotoxicity by the combination of Amphotericin B (lipid complex) and Streptomycin

Recommended Action
Management		Just before the start and just before the end of each amphotericin infusion, hydration of the patient with 500 mL of normal saline may be helpful. The patient's renal function should be monitored frequently during therapy.

References
1	Churchill DN, Seely J "Nephrotoxicity associated with combined gentamicin - amphotericin B therapy." Nephron 19 (1977): 176-81. [PMID: 268496]
2	Product Information. Abelcet (amphotericin B). Liposome Company Inc, The, Princeton, NJ.
3	Product Information. Arikayce (amikacin liposome). Insmed Incorporated, Bridgewater, NJ.