Drug General Information (ID: DDIFPKMEVS)
Drug Name			Amphotericin B (lipid complex)		Drug Info		Givosiran		Drug Info
Drug Type		Small molecule				Small interfering RNA
Therapeutic Class		Antifungal Agents				Metabolic Agents
Structure

Mechanism of Amphotericin B (lipid complex)-Givosiran Interaction (Severity Level: Moderate)
Increased risk of nephrotoxicity Click to Show/Hide Mechanism Graph
Drug Name		Amphotericin B (lipid complex)				Givosiran
Mechanism		Nephrotoxicity				Nephrotoxicity
Key Mechanism Factor 1
		Factor Name		Nephrotoxicity
		Factor Description		The combination of drugs that can induce nephrotoxicity may increase the risk of kidney injury. When kidney injury occurs, the inability to remove excess urine and waste from the body can lead to high levels of urea nitrogen, creatinine, and electrolytes (such as potassium and magnesium) in the blood.
Mechanism Description		Increased risk of nephrotoxicity by the combination of Amphotericin B (lipid complex) and Givosiran

Recommended Action
Management		Close clinical and laboratory monitoring of renal and neurologic function and drug serum concentrations (if clinically appropriate) is recommended.

References
1	Cerner Multum, Inc. "Australian Product Information.".
2	Cerner Multum, Inc. "UK Summary of Product Characteristics.".