Drug General Information (ID: DDIKN75F3V)
Drug Name			Zidovudine		Drug Info		Irinotecan		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Anti-Hiv Agents				Antineoplastics
Structure

Mechanism of Zidovudine-Irinotecan Interaction (Severity Level: Moderate)
Additive immunosuppressive effects Click to Show/Hide Mechanism Graph
Drug Name		Zidovudine				Irinotecan
Mechanism		Myelosuppressive effects				Myelosuppressive effects
Key Mechanism Factor 1
		Factor Name		Immunosuppressive effects
		Factor Description		Immunosuppression is when your immune system is not functioning as it should. The immune system is made up of cells, tissues and organs that help the body fight off infections. If the immune system is suppressed, an infection that your body was able to control may become serious or even fatal.
Mechanism Description		Additive immunosuppressive effects by the combination of Zidovudine and Irinotecan

Recommended Action
Management		Hematological parameters should be closely monitored. Some authorities recommend dosages of one or both agents may be adjusted if necessary.

References
1	Cerner Multum, Inc. "Australian Product Information.".
2	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
3	Product Information. Retrovir (zidovudine). Glaxo Wellcome, Research Triangle Park, NC.